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Itano, Junko Department of Respiratory Medicine, Okayama University Hospital
Higo, Hisao Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Ohashi, Kadoaki Department of Respiratory Medicine, Okayama University Hospital ORCID Kaken ID researchmap
Makimoto, Go Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Nishii, Kazuya Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Hotta, Katsuyuki Department of Respiratory Medicine, Okayama University Hospital Kaken ID publons researchmap
Miyahara, Nobuaki Department of Respiratory Medicine, Okayama University Hospital Kaken ID publons researchmap
Maeda, Yoshinobu Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID researchmap
Kiura, Katsuyuki Department of Respiratory Medicine, Okayama University Hospital ORCID Kaken ID publons researchmap
Abstract
Osimertinib is the standard therapy for epidermal-growth-factor-receptor (EGFR)-mutant lung cancers. We herein report a case of osimertinib-induced interstitial lung disease (OsiILD) with an organizing pneumonia (OP) pattern and provide a literature-based review. Six months after osimertinib administration, a 75-year-old woman with right pleural carcinomatosis developed ILD with an OP pattern. After salvage chemotherapy, osimertinib with corticosteroid was successfully re-administered. A literature review suggested that 1) OsiILD with an OP pattern was rare but should be recognized, and 2) re-administration of osimertinib in OsiILD was successful in select patients. A criterion that determines whether a patient would benefit from re-administration is warranted.
Keywords
osimertinib
drug-induced ILD
reversed halo sign
organizing pneumonia pattern
re-administration
Published Date
2020-03-15
Publication Title
Internal Medicine
Volume
volume59
Issue
issue6
Publisher
The Japanese Society of Internal Medicine
Start Page
823
End Page
828
ISSN
0918-2918
NCID
AA10827774
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
Copyright Holders
© 2020 by The Japanese Society of Internal Medicine
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isVersionOf https://doi.org/10.2169/internalmedicine.3689-19
Citation
Junko Itano, Hisao Higo, Kadoaki Ohashi, Go Makimoto, Kazuya Nishii, Katsuyuki Hotta, Nobuaki Miyahara, Yoshinobu Maeda, Katsuyuki Kiura, Successful Re-administration of Osimertinib in Osimertinib-induced Interstitial Lung Disease with an Organizing Pneumonia Pattern: A Case Report and Literature Review, Internal Medicine, 2020, Volume 59, Issue 6, Pages 823-828, Released March 15, 2020, [Advance publication] Released November 29, 2019, Online ISSN 1349-7235, Print ISSN 0918-2918, https://doi.org/10.2169/internalmedicine.3689-19