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ID 49552
FullText URL
Author
Hirakawa, Tomoko
Kato, Jun
Okumura, Yoshihiro
Hori, Keisuke
Takahashi, Sakuma
Suzuki, Hideyuki
Akita, Mitsuhiro
Higashi, Reiji
Saito, Shunsuke
Kaji, Eisuke
Uraoka, Toshio
Abstract
The purpose of this study was to analyze the detectability of colorectal neoplasia with fluorine-18-2-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography (FDG-PET/CT). Data for a total of 492 patients who had undergone both PET/CT and colonoscopy were analyzed. After the findings of PET/CT and colonoscopy were determined independently, the results were compared in each of the six colonic sites examined in all patients. The efficacy of PET/CT was determined using colonoscopic examination as the gold standard. In all, 270 colorectal lesions 5 mm or more in size, including 70 pathologically confirmed malignant lesions, were found in 172 patients by colonoscopy. The sensitivity and specificity of PET/CT for detecting any of the colorectal lesions were 36 and 98%, respectively. For detecting lesions 11 mm or larger, the sensitivity was increased to 85%, with the specificity remaining consistent (97%). Moreover, the sensitivity for tumors 21 mm or larger was 96% (48/50). Tumors with malignant or high-grade pathology were likely to be positive with PET/CT. A size of 10 mm or smaller [odds ratio (OR) 44.14, 95% confidence interval (95% CI) 11.44-221.67] and flat morphology (OR 7.78, 95% CI 1.79-36.25) were significant factors that were associated with false-negative cases on PET/CT. The sensitivity of PET/CT for detecting colorectal lesions is acceptable, showing size- and pathology-dependence, suggesting, for the most part, that clinically relevant lesions are detectable with PET/CT. However, when considering PET/CT for screening purposes caution must be exercised because there are cases of false-negative results.
Keywords
Colorectal neoplasia
Positron emission tomography
Computed tomography
Cancer screening
Colonoscopy
Published Date
2012-02
Publication Title
Journal of Gastroenterology
Volume
volume47
Issue
issue2
Start Page
127
End Page
135
ISSN
0944-1174
Content Type
Journal Article
Official Url
http://dx.doi.org/10.1007/s00535-011-0473-z
Related Url
http://ousar.lib.okayama-u.ac.jp/metadata/49122
language
英語
File Version
author
Refereed
True
DOI
Web of Science KeyUT