このエントリーをはてなブックマークに追加
ID 52797
FullText URL
Author
Nishikawa, Hitoshi
Oto, Takahiro Kaken ID publons
Otani, Shinji
Harada, Masaaki
Iga, Norichika
Miyoshi, Kentaroh Kaken ID
Miyoshi, Shinichiro Kaken ID publons researchmap
Abstract
Objective: The shortage of organ donors is a serious problem in Japan. The right and left upper lobes of rejected extended-criteria lungs have the potential to be used for downsized lung transplantation; however, the 2 upper lobes are too small for a size-matched recipient. The present study investigated the feasibility of unilateral transplantation using the right and left upper lobes. Methods: After harvesting the heart-lung block from donor swine, a left lung graft was created using the right and left upper lobes and transplanted into the left thoracic space of the recipient swine (group A, n = 5). We then evaluated graft function for 6 hours and compared these results with those of a control group (group B, n = 5), in which orthotopic left lung transplantation had been performed. Results: The mean partial pressure of oxygen in the arterial blood gas after reperfusion was 507 mm Hg in group A and 463 mm Hg in group B (P = .2). The mean pulmonary arterial pressure was 30.3 mm Hg in group A and 27.5 mm Hg in group B (P = .4). The mean airway pressure was 6.4 mm Hg in group A and 6.2 mm Hg in group B (P = .7). Conclusions: Our results suggest that unilateral left lung transplantation using the right and left upper lobes is technically and functionally feasible for size-matched recipients. In addition, this technique enables the use of rejected lungs if the upper lobes are still intact.
Published Date
2013-12
Publication Title
The Journal of Thoracic and Cardiovascular Surgery
Volume
volume146
Issue
issue6
Start Page
1534
End Page
1537
ISSN
0022-5223
Content Type
Journal Article
Related Url
http://ousar.lib.okayama-u.ac.jp/metadata/52521
language
英語
File Version
author
Refereed
True
DOI
Web of Science KeyUT