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ID 52797
FullText URL
Author
Nishikawa, Hitoshi
Otani, Shinji
Harada, Masaaki
Abstract
Objective: The shortage of organ donors is a serious problem in Japan. The right and left upper lobes of rejected extended-criteria lungs have the potential to be used for downsized lung transplantation; however, the 2 upper lobes are too small for a size-matched recipient. The present study investigated the feasibility of unilateral transplantation using the right and left upper lobes. Methods: After harvesting the heart-lung block from donor swine, a left lung graft was created using the right and left upper lobes and transplanted into the left thoracic space of the recipient swine (group A, n = 5). We then evaluated graft function for 6 hours and compared these results with those of a control group (group B, n = 5), in which orthotopic left lung transplantation had been performed. Results: The mean partial pressure of oxygen in the arterial blood gas after reperfusion was 507 mm Hg in group A and 463 mm Hg in group B (P = .2). The mean pulmonary arterial pressure was 30.3 mm Hg in group A and 27.5 mm Hg in group B (P = .4). The mean airway pressure was 6.4 mm Hg in group A and 6.2 mm Hg in group B (P = .7). Conclusions: Our results suggest that unilateral left lung transplantation using the right and left upper lobes is technically and functionally feasible for size-matched recipients. In addition, this technique enables the use of rejected lungs if the upper lobes are still intact.
Published Date
2013-12
Publication Title
The Journal of Thoracic and Cardiovascular Surgery
Volume
volume146
Issue
issue6
Start Page
1534
End Page
1537
ISSN
0022-5223
Content Type
Journal Article
Related Url
http://ousar.lib.okayama-u.ac.jp/metadata/52521
language
英語
File Version
author
Refereed
True
DOI
Web of Sience KeyUT