JaLCDOI 10.18926/AMO/58269
FullText URL 74_2_115.pdf
Author Kotani, Sayoko| Kamada, Yasuhiko| Shimizu, Keiko| Sakamoto, Ai| Nakatsuka, Mikiya| Hiramatsu, Yuji| Masuyama, Hisashi|
Abstract Thrombosis in decidual vessels is one of the mechanisms of pregnancy loss. However, few studies have assessed the relation between platelet activation, which is known to cause of thrombosis, and recurrent pregnancy loss (RPL). We investigated platelet activation in women with RPL compared to controls by measuring plasma levels of platelet factor 4 (PF4) and β-thromboglobulin (βTG), and assessed correlations between PF4/βTG and coagulative risk factors associated with RPL. The study group included 135 women who had experienced two or more consecutive pregnancy losses. The control group included 28 age-matched healthy women who had never experienced pregnancy loss. PF4 and βTG plasma levels were significantly higher in the women with RPL than controls (PF4: 14.0 [8.0-20.0] vs. 9.0 [6.0-12.0] ng/ml, p=0.043; βTG: 42.0 [24.3-59.8] vs. 31.5 [26.6-36.4] ng/ml, p=0.002). There was a significant association between βTG and anti-phosphatidylethanolamine antibody immunoglobulin M (aPE IgM) (p=0.048). Among the women with RPL, 18 of those who were positive for PF4 (45%) and 18 of those who were positive for βTG (37%) were negative for all known coagulative risk factors associated with RPL. Measurements of PF4 and βTG may be important because they help identify women who are at risk of RPL.
Keywords recurrent pregnancy loss platelet factor 4 β-thromboglobulin platelet activation
Amo Type Original Article
Published Date 2020-04
Publication Title Acta Medica Okayama
Volume volume74
Issue issue2
Publisher Okayama University Medical School
Start Page 115
End Page 122
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32341585
Web of Science KeyUT 000528278500004
Author Kamada, Yasuhiko| Hiramatsu, Yuji|
Published Date 2008-01-04
Publication Title 岡山医学会雑誌
Volume volume119
Issue issue3
Content Type Journal Article
Author 鎌田 泰彦|
Published Date 2001-03-25
Publication Title
Content Type Thesis or Dissertation