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ID 57570
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MIZUNO, HIROFUMI Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
MIYAI, HISATAKA Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
YOKOI, AYA Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
KOBAYASHI, TERUMASA Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
INABU, CHIAKI Junpukai Daiku Dental Clinic
MARUYAMA, TAKAYUKI Center for Innovative Clinical Medicine, Okayama University Hospital
EKUNI, DAISUKE Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID Kaken ID publons researchmap
MIZUKAWA, NOBUYOSHI Department of Oral and Maxillofacial Reconstructive Surgery, Okayama University Hospital
KARIYA, SHIN Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID Kaken ID publons researchmap
NISHIZAKI, KAZUNORI Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID publons researchmap
KIMATA, YOSHIHIRO Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID publons researchmap
MORITA, MANABU Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID Kaken ID publons researchmap
Abstract
BACKGROUND/AIM:
The aim of this retrospective cohort study was to investigate the association between renal dysfunction (RD) and the development of oral mucositis (OM) in patients undergoing concurrent chemoradiotherapy (CCRT) for pharyngeal cancer including radiation to the oral cavity.
PATIENTS AND METHODS:
Of 130 patients diagnosed as having pharyngeal cancer who received CCRT at the Okayama University Hospital Head and Neck Cancer Center, 44 were finally selected.
RESULTS:
During the observation period, 24 (54.5%) patients experienced severe OM (grade 3). The Cox proportional hazards regression model demonstrated that RD (hazard ratio(HR)=2.45, 95% confidence interval(CI)=1.067-6.116, p=0.035) and nasopharynx/oropharynx as center of the irradiated area (HR=2.56, 95% CI=1.072-5.604, p=0.034) were significantly associated with the incidence of severe OM (grade 3).
CONCLUSION:
In patients with pharyngeal cancer treated with CCRT including radiation to the oral cavity, RD at baseline can be a risk factor for developing severe OM.
Keywords
Head and neck cancer
concurrent chemoradiotherapy
creatinine clearance
oral mucositis
renal dysfunction
Published Date
2019-01
Publication Title
In Vivo
Volume
volume33
Issue
issue1
Publisher
The International Institute of Anticancer Research
Start Page
183
End Page
189
ISSN
0258-851X
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
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publisher
PubMed ID
DOI
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isVersionOf https://doi.org/10.21873/invivo.11457