Okayama University Medical SchoolActa Medica Okayama0386-300X7032016Structure of a New Palatal Plate and the Artificial Tongue for Articulation Disorder in a Patient with Subtotal Glossectomy205211ENKen-ichiKozakiDepartment of Dental Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical SciencesShigehisaKawakamiDepartment of Occlusal and Oral Functional Rehabilitation, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical SciencesTakayukiKonishiDivision of Physical Medicine and Rehabilitation, Okayama University HospitalKeijiOhtaDental Laboratory Division, Okayama University HospitalJitsuroYanoDepartment of Occlusal and Oral Functional Rehabilitation, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical SciencesTomooOnodaDepartment of Otolaryngology-Head and Neck Surgery Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical SciencesHiroshiMatsumotoDepartment of Plastic and Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical SciencesNobuyoshiMizukawaDepartment of Oral and Maxillofacial Reconstructive Surgery, Okayama University HospitalYoshihiroKimataDepartment of Plastic and Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical SciencesKazunoriNishizakiDepartment of Otolaryngology-Head and Neck Surgery Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical SciencesSeijiIidaDepartment of Oral and Maxillofacial Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical SciencesAkioGofukuGraduate School of Natural Science and Technology, Okayama UniversityMasanobuAbeDepartment of Computer Science, Okayama UniversityShogoMinagiDepartment of Occlusal and Oral Functional Rehabilitation, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical SciencesOkayama Dream Speech ProjectCase Report10.18926/AMO/54420A palatal augmentation prosthesis (PAP) is used to facilitate improvement in the speech and swallowing functions of patients with tongue resection or tongue movement disorders. However, a PAPʼs effect is limited in cases where articulation disorder is severe due to wide glossectomy and/or segmental mandibulectomy. In this paper, we describe speech outcomes of a patient with an articulation disorder following glossectomy and segmental mandibulectomy. We used a palatal plate (PP) based on a PAP, along with an artificial tongue (KAT). Speech improvement was evaluated by a standardized speech intelligibility test consisting of 100 syllables. The speech intelligibility score was significantly higher when the patient wore both the PP and KAT than when he wore neither (p＝0.013). The conversational intelligibility score was significantly improved with the PP and KAT than without PP and KAT (p＝0.024). These results suggest that speech function can be improved in patients with hard tissue defects with segmental mandibulectomy using both a PP and a KAT. The nature of the design of the PP and that of the KAT will allow these prostheses to address a wide range of tissue defects.No potential conflict of interest relevant to this article was reported.Pergamon-Elsevier Science Ltd.Acta Medica Okayama0003-99695922014Memory-related gene expression profile of the male rat hippocampus induced by teeth extraction and occlusal support recovery133141ENSachiyoIidaTetsuyaHaraDaisukeArakiChisaIshimine-KurodaAkimasaKurozumiShunichiSakamotoTakakoMiyazakiShogoMinagiObjectives: The present study aimed to identify the effect of memory-related genes on male rats tested for spatial memory with either molar teeth extraction or its restoration by occlusal support using experimental dentures.
Design: Memory-related genes were detected from hippocampi of male Wistar rats (exposed to teeth extraction with or without dentures, or no extraction (control)) (7-week old) after behavioural testing (via the radial maze task) using a DNA microarray. The time course of the expression of these genes was evaluated by quantitative real-time polymerase chain reaction (PCR) (on 49-week-old rats).
Results: In preliminary experiments, to determine which memory genes are affected by spatial memory training, DNA microarray analysis revealed that thyrotropin-releasing hormone (Trh) and tenascin XA (Tnxa) were up-regulated and neuronatin (Nnat) and S100a9 were down-regulated after the maze training. The expression of Tnxa, Nnat and S100a9 of 49-week-old rats (during the time course) via quantitative real-time PCR was consistent with the results of microarrays of the preliminary experiment. Expression of Trh that was evaluated by quantitative real-time PCR did not agree with the results for this gene from the microarray for all groups. Therefore, expression of Trh may have increased in only young, trained rats. The expression of S100a9 prior to the maze task was down-regulated in only the extraction group.
Conclusion: These results demonstrated that Trh, Tnxa and Nnat genes were affected according to the degree of memory in male rats. This study also indicated that S100a9 is a memory-related gene, which is affected by the presence of occlusal support.No potential conflict of interest relevant to this article was reported.岡山歯学会Acta Medica Okayama0913-39412812009岡山大学病院周術期管理センター(歯科部門)設立後5ヵ月間の活動内容および今後の展開3742ENReikoYamanakaYoshihikoSogaKumikoNawachiYoshinobuYanagiNaokiKodamaTakashiNakataRumiMiuraMisaoHagawaTetsuoTakeuchiMiekoYamaneManabuMoritaShogoTakashibaJun-ichiAsamiShogoMinagiMasahiroYoshiyamaTsutomuShimonoTakuoKubokiAkiraSasakiKiyoshiMoritaNo potential conflict of interest relevant to this article was reported.