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Tanino, Masaaki Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kobayashi, Motomu Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Sasaki, Toshihiro Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Takata, Ken Department of Anesthesiology and Intensive Care Medicine, Kawasaki Medical School
Takeda, Yoshimasa Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Mizobuchi, Satoshi Division of Anesthesiology, Department of Surgery Related, Kobe University Graduate School of Medicine
Morita, Kiyoshi Okayama University
Nagai, Taku Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine
Morimatsu, Hiroshi Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Abstract
Postoperative cognitive dysfunction (POCD) occurs in nearly one-third of patients after non-cardiac surgery. Many animal behavior studies have investigated the effect of general anesthesia on cognitive function. However, there have been no studies examining the effects on working memory specifically, with a focus on the retention of working memory. We demonstrate here that isoflurane anesthesia induces deficits in the retention of spatial working memory in rats, as revealed by an increase in isoflurane-induced across-phase errors in the delayed spatial win-shift (SWSh) task with a 30-min delay in an 8-arm radial arm maze on post-anesthesia days (PADs) 1,2,4, and 10. A post-hoc analysis revealed a significant increase in across-phase errors on PAD 1 and recovery on PAD 10 in the isoflurane group. In contrast, within-phase errors independent of the retention of working memory were unaffected by isoflurane. These results demonstrate that isoflurane anesthesia transiently impairs the retention of spatial working memory in rats.
Keywords
postoperative cognitive dysfunction
isoflurane
spatial working memory
retention
delayed spatial win-shift task
Amo Type
Original Article
Published Date
2016-12
Publication Title
Acta Medica Okayama
Volume
volume70
Issue
issue6
Publisher
Okayama University Medical School
Start Page
455
End Page
460
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
Copyright Holders
CopyrightⒸ 2016 by Okayama University Medical School
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publisher
Refereed
True
PubMed ID