FullText URL fulltext.pdf
Author Matsumoto, Naohisa| Nishimoto, Rei| Matsuoka, Yoshikazu| Takeda, Yoshimasa| Morimatsu, Hiroshi|
Keywords Anesthetic management Myotonia congenita Nondystrophic myotonia Paramyotonia congenita Periodic paralysis Potassium-aggravated myotonia Skeletal muscle channelopathy Sodium-channel myotonia
Published Date 2019-11-25
Publication Title JA Clinical Reports
Volume volume5
Issue issue1
Publisher Springer
Start Page 77
ISSN 2363-9024
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s). 2019
File Version publisher
PubMed ID 32026975
DOI 10.1186/s40981-019-0300-8
Web of Science KeyUT 000534692000001
Related Url isVersionOf https://doi.org/10.1186/s40981-019-0300-8
Author Tomotsuka, Naoto| Kaku, Ryuji| Obata, Norihiko| Matsuoka, Yoshikazu| Kanzaki, Hirotaka| Taniguchi, Arata| Muto, Noriko| Omiya, Hiroki| Itano, Yoshitaro| Sato, Tadasu| Ichikawa, Hiroyuki| Mizobuchi, Satoshi| Morimatsu, Hiroshi|
Published Date 2014-07-11
Publication Title Journal of Pain Research
Volume volume7
Content Type Journal Article
JaLCDOI 10.18926/AMO/48569
FullText URL 66_3_285.pdf
Author Mizobuchi, Satoshi| Matsuoka, Yoshikazu| Obata, Norihiko| Kaku, Ryuji| Itano, Yoshitaro| Tomotsuka, Naoto| Taniguchi, Arata| Nishie, Hiroyuki| Kanzaki, Hirotaka| Ouchida, Mamoru| Morita, Kiyoshi|
Abstract Perioperative beta-blocker administration has recently been recommended for patients undergoing cardiac or other surgery due to the beneficial cardiovascular effects of these agents. In addition, some studies have reported that perioperatively administered beta-blockers also have analgesic effects. In this study, to investigate the antinociceptive effects and the analgesic profile of landiolol, we examined the effects of intrathecal landiolol administration on nociceptive pain behavior and c-fos mRNA expression (a neural marker of pain) in the spinal cord using a rat formalin model. We found that pain-related behavior was inhibited by intrathecal landiolol administration. Moreover, the increase in c-fos mRNA expression on the formalin-injected side was less pronounced in rats administered landiolol than in saline administered controls. Thus, intrathecal administration of landiolol exhibited antinociceptive effects. Further investigation of the antinociceptive mechanism of landiolol is required.
Keywords beta-blocker landiolol formalin pain behavior c-fos
Amo Type Original Article
Published Date 2012-06
Publication Title Acta Medica Okayama
Volume volume66
Issue issue3
Publisher Okayama University Medical School
Start Page 285
End Page 289
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2012 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 22729110
Web of Science KeyUT 000305669700013