| FullText URL | fulltext.pdf |
|---|---|
| Author | Shikata, Kenichi| Haneda, Masakazu| Ninomiya, Toshiharu| Koya, Daisuke| Suzuki, Yoshiki| Suzuki, Daisuke| Ishida, Hitoshi| Akai, Hiroaki| Tomino, Yasuhiko| Uzu, Takashi| Nishimura, Motonobu| Maeda, Shiro| Ogawa, Daisuke| Miyamoto, Satoshi| Makino, Hirofumi| the Diabetic Nephropathy Remission and Regression Team Trial in Japan (DNETT‐Japan) collaborative group| |
| Keywords | Diabetic kidney disease Diabetic nephropathy Diabetic Nephropathy Remission and Regression Team Trial in Japan |
| Published Date | 2020-08-08 |
| Publication Title | Journal of Diabetes Investigation |
| Publisher | Wiley |
| ISSN | 2040-1116 |
| NCID | AA12488319 |
| Content Type | Journal Article |
| language | 英語 |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 The Authors |
| File Version | Publisher |
| PubMed ID | 32597548 |
| DOI | 10.1111/jdi.13339 |
| Web of Science KeyUT | 000557091100001 |
| Related Url | isVersionOf https://doi.org/10.1111/jdi.13339 |
| FullText URL | Mod_Rheumatol_26_5_730.pdf |
|---|---|
| Author | Sada, Ken-ei| Harigai, Masayoshi| Amano, Koichi| Atsumi, Tatsuya| Fujimoto, Shouichi| Yuzawa, Yukio| Takasaki, Yoshinari| Banno, Shogo| Sugihara, Takahiko| Kobayashi, Masaki| Usui, Joichi| Yamagata, Kunihiro| Homma, Sakae| Dobashi, Hiroaki| Tsuboi, Naotake| Ishizu, Akihiro| Sugiyama, Hitoshi| Okada, Yasunori| Arimura, Yoshihiro| Matsuo, Seiichi| Makino, Hirofumi| |
| Keywords | Antineutrophil cytoplasmic antibody-associated vasculitis Eosinophilic granulomatosis with polyangiitis Granulomatosis with polyangiitis Inception cohort Microscopic polyangiitis |
| Note | This is an Accepted Manuscript of an article published by Taylor & Francis Group| |
| Published Date | 2016-03-11 |
| Publication Title | Modern Rheumatology |
| Volume | volume26 |
| Issue | issue5 |
| Publisher | Taylor & Francis |
| Start Page | 730 |
| End Page | 737 |
| ISSN | 1439-7595 |
| NCID | AA1157187X |
| Content Type | Journal Article |
| language | 英語 |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| File Version | author |
| PubMed ID | 26873424 |
| DOI | 10.3109/14397595.2016.1140274 |
| Web of Science KeyUT | 000393120600018 |
| Related Url | https://doi.org/10.3109/14397595.2016.1140274 |
| Title Alternative | The perception of chronic kidney disease in a general population in Okayama, Japan : 2015 |
|---|---|
| FullText URL | 129_101.pdf |
| Author | Uchida, Haruhito A.| Sugiyama, Hitoshi| Miyazaki, Masashi| Wada, Jun| Shikata, Kenichi| Kashihara, Naoki| Makino, Hirofumi| |
| Abstract | Public education programs about chronic kidney disease (CKD) have been performed in Okayama, Japan for the past 10 years. The present study investigated the perception of CKD in a general population in Okayama. In October and November 2015, a questionnaire survey was distributed by 12 medical centers in five medical districts in Okayama prefecture. A total of 7,022 respondents who underwent their physical checkup at these centers answered the questionnaire. In response to a questionnaire item asking about the respondent's familiarity with the term "CKD," only 4% of the respondents answered "know it well" and 10% answered "unfamiliar." In contrast, in response to a questionnaire item asking about the respondent's familiarity with "chronic kidney disease," 27% answered "know it well" and 38% answered "unfamiliar." The leading avenue by which the respondents learned about CKD/chronic kidney disease was television, followed by newspapers, magazines, and a family doctor or nurse. The leading component which the respondents considered essential for the diagnosis of CKD/chronic kidney disease was proteinuria. A stratified analysis demonstrated a higher recognition of “CKD" or “chronic kidney disease" in the medical districts in northern Okayama prefecture compared to southern Okayama prefecture. These results indicated that the awareness of CKD in Okayama prefecture is still inadequate. Many people did not appear to realize that the term “CKD" represents "chronic kidney disease". Further continuous public education efforts are required to enlighten people about CKD/chronic kidney disease. |
| Keywords | 慢性腎臓病 (chronic kidney disease) CKD 認知度 (perception) 岡山県 (Okayama) 医療圏別 (medical distinct) |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2017-08-01 |
| Volume | volume129 |
| Issue | issue2 |
| Start Page | 101 |
| End Page | 105 |
| ISSN | 0030-1558 |
| Related Url | https://doi.org/10.4044/joma.129.101 |
| language | 日本語 |
| Copyright Holders | Copyright (c) 2017 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.129.101 |
| NAID | 130006039371 |
| Title Alternative | Clinical Research Core Center and Okayama University |
|---|---|
| FullText URL | 129_45.pdf |
| Author | Makino, Hirofumi| |
| Keywords | オール岡山大学 臨床研究中核病院 橋渡し研究加速ネットワークプログラム事業 |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2017-04-03 |
| Volume | volume129 |
| Issue | issue1 |
| Start Page | 45 |
| End Page | 49 |
| ISSN | 0030-1558 |
| language | 日本語 |
| Copyright Holders | Copyright (c) 2017 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.129.45 |
| NAID | 130005632070 |
| Author | Watanabe, Mayu| Nakatsuka, Atsuko| Murakami, Kazutoshi| Inoue, Kentaro| Terami, Takahiro| Higuchi, Chigusa| Katayama, Akihiro| Teshigawara, Sanae| Eguchi, Jun| Ogawa, Daisuke| Watanabe, Eijiro| Wada, Jun| Makino, Hirofumi| |
|---|---|
| Published Date | 2014-05-25 |
| Publication Title | PLOS ONE |
| Volume | volume9 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Ogawa, Daisuke| Eguchi, Jun| Wada, Jun| Terami, Naoto| Hatanaka, Takashi| Tachibana, Hiromi| Nakatsuka, Atsuko| Sato Horiguchi, Chikage| Nishii, Naoko| Makino, Hirofumi| |
|---|---|
| Published Date | 2014-01-22 |
| Publication Title | PLOS ONE |
| Volume | volume9 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Katayama, Akihiro| Nakatsuka, Atsuko| Eguchi, Jun| Murakami, Kazutoshi| Teshigawara, Sanae| Kanzaki, Motoko| Nunoue, Tomokazu| Hida, Kazuyuki| Wada, Nozomu| Yasunaka, Tetsuya| Ikeda, Fusao| Takaki, Akinobu| Yamamoto, Kazuhide| Kiyonari, Hiroshi| Makino, Hirofumi| Wada, Jun| |
|---|---|
| Published Date | 2015 |
| Publication Title | Scientific reports |
| Volume | volume5 |
| Content Type | Journal Article |
| Author | Kitamura, Shinji| Sakurai, Hiroyuki| Makino, Hirofumi| |
|---|---|
| Published Date | 2015-03 |
| Publication Title | Stem cells |
| Volume | volume33 |
| Issue | issue3 |
| Content Type | Journal Article |
| Title Alternative | Advances in Diabetology, The 49th Annual Post Graduate Course |
|---|---|
| FullText URL | 127_167.pdf |
| Author | Makino, Hirofumi| |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2015-08-03 |
| Volume | volume127 |
| Issue | issue2 |
| Start Page | 167 |
| End Page | 168 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.127.167 |
| language | 日本語 |
| Copyright Holders | Copyright (c) 2015 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.127.167 |
| NAID | 130005096244 |
| JaLCDOI | 10.18926/AMO/53117 |
|---|---|
| FullText URL | 69_1_1.pdf |
| Author | Watatani, Hiroyuki| Yamasaki, Hiroko| Maeshima, Yohei| Nasu, Tatsuyo| Hinamoto, Norikazu| Ujike, Haruyo| Sugiyama, Hitoshi| Sakai, Yoshiki| Tanabe, Katsuyuki| Makino, Hirofumi| |
| Abstract | Diabetic nephropathy is the most common pathological disorder predisposing patients to end-stage renal disease. Considering the increasing prevalence of type 2 diabetes mellitus worldwide, novel therapeutic approaches are urgently needed. ONO-1301 is a novel sustained-release prostacyclin analog that inhibits thromboxane A2 synthase. Here we examined the therapeutic effects of the intermittent administration of slow-release ONO-1301 (SR-ONO) on diabetic nephropathy in obese type 2 diabetes mice, as well as its direct effects on mesangial cells. The subcutaneous injection of SR-ONO (3mg/kg) every 3 wks did not affect the obesity or hyperglycemia in the db/db obese mice used as a model of type 2 diabetes, but it significantly ameliorated their albuminuria, glomerular hypertrophy, glomerular accumulation of type IV collagen, and monocyte/macrophage infiltration, and also the increase of TGF-β1, α-smooth muscle actin (α-SMA) and MCP-1 compared to vehicle treatment. In cultured mouse mesangial cells, ONO-1301 concentration-dependently suppressed the increases in TGF-β, type IV collagen, α-SMA, MCP-1 and fibronectin induced by high ambient glucose, at least partly through prostacyclin (PGI2) receptor-mediated signaling. Taken together, these results suggest the potential therapeutic efficacy of the intermittent administration of SR-ONO against type 2 diabetic nephropathy, possibly through protective effects on mesangial cells. |
| Keywords | prostacyclin ONO-1301 diabetic nephropathy TGF-β1 diabetes mellitus |
| Amo Type | Original Article |
| Published Date | 2015-02 |
| Publication Title | Acta Medica Okayama |
| Volume | volume69 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 1 |
| End Page | 15 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | 英語 |
| Copyright Holders | CopyrightⒸ 2015 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 25703166 |
| Web of Science KeyUT | 000349740300001 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/53128 |
| Author | Tsuji, Kenji| Kitamura, Shinji| Makino, Hirofumi| |
|---|---|
| Published Date | 2014-04-25 |
| Publication Title | Biochemical and Biophysical Research Communications |
| Volume | volume447 |
| Issue | issue1 |
| Content Type | Journal Article |
