| FullText URL | Mod_Rheumatol_26_5_730.pdf |
|---|---|
| Author | Sada, Ken-ei| Harigai, Masayoshi| Amano, Koichi| Atsumi, Tatsuya| Fujimoto, Shouichi| Yuzawa, Yukio| Takasaki, Yoshinari| Banno, Shogo| Sugihara, Takahiko| Kobayashi, Masaki| Usui, Joichi| Yamagata, Kunihiro| Homma, Sakae| Dobashi, Hiroaki| Tsuboi, Naotake| Ishizu, Akihiro| Sugiyama, Hitoshi| Okada, Yasunori| Arimura, Yoshihiro| Matsuo, Seiichi| Makino, Hirofumi| |
| Keywords | Antineutrophil cytoplasmic antibody-associated vasculitis Eosinophilic granulomatosis with polyangiitis Granulomatosis with polyangiitis Inception cohort Microscopic polyangiitis |
| Note | This is an Accepted Manuscript of an article published by Taylor & Francis Group |
| Published Date | 2016-03-11 |
| Publication Title | Modern Rheumatology |
| Volume | volume26 |
| Issue | issue5 |
| Publisher | Taylor & Francis |
| Start Page | 730 |
| End Page | 737 |
| ISSN | 1439-7595 |
| NCID | AA1157187X |
| Content Type | Journal Article |
| language | 英語 |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| File Version | author |
| PubMed ID | 26873424 |
| DOI | 10.3109/14397595.2016.1140274 |
| Web of Sience KeyUT | 000393120600018 |
| Related Url | https://doi.org/10.3109/14397595.2016.1140274 |
| Title Alternative | The perception of chronic kidney disease in a general population in Okayama, Japan : 2015 |
|---|---|
| Author | Uchida, Haruhito A.| Sugiyama, Hitoshi| Miyazaki, Masashi| Wada, Jun| Shikata, Kenichi| Kashihara, Naoki| Makino, Hirofumi| |
| Abstract | Public education programs about chronic kidney disease (CKD) have been performed in Okayama, Japan for the past 10 years. The present study investigated the perception of CKD in a general population in Okayama. In October and November 2015, a questionnaire survey was distributed by 12 medical centers in five medical districts in Okayama prefecture. A total of 7,022 respondents who underwent their physical checkup at these centers answered the questionnaire. In response to a questionnaire item asking about the respondent's familiarity with the term "CKD," only 4% of the respondents answered "know it well" and 10% answered "unfamiliar." In contrast, in response to a questionnaire item asking about the respondent's familiarity with "chronic kidney disease," 27% answered "know it well" and 38% answered "unfamiliar." The leading avenue by which the respondents learned about CKD/chronic kidney disease was television, followed by newspapers, magazines, and a family doctor or nurse. The leading component which the respondents considered essential for the diagnosis of CKD/chronic kidney disease was proteinuria. A stratified analysis demonstrated a higher recognition of “CKD" or “chronic kidney disease" in the medical districts in northern Okayama prefecture compared to southern Okayama prefecture. These results indicated that the awareness of CKD in Okayama prefecture is still inadequate. Many people did not appear to realize that the term “CKD" represents "chronic kidney disease". Further continuous public education efforts are required to enlighten people about CKD/chronic kidney disease. |
| Keywords | 慢性腎臓病 (chronic kidney disease) CKD 認知度 (perception) 岡山県 (Okayama) 医療圏別 (medical distinct) |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2017-08-01 |
| Volume | volume129 |
| Issue | issue2 |
| Start Page | 101 |
| End Page | 105 |
| ISSN | 0030-1558 |
| Related Url | https://doi.org/10.4044/joma.129.101 |
| language | 日本語 |
| Copyright Holders | Copyright (c) 2017 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.129.101 |
| Title Alternative | Clinical Research Core Center and Okayama University |
|---|---|
| Author | Makino, Hirofumi| |
| Keywords | オール岡山大学 臨床研究中核病院 橋渡し研究加速ネットワークプログラム事業 |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2017-04-03 |
| Volume | volume129 |
| Issue | issue1 |
| Start Page | 45 |
| End Page | 49 |
| ISSN | 0030-1558 |
| Official Url | http://www.okayama-u.ac.jp/user/oma/| |
| language | 日本語 |
| Copyright Holders | Copyright (c) 2017 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.129.45 |
| Author | Watanabe, Mayu| Nakatsuka, Atsuko| Murakami, Kazutoshi| Inoue, Kentaro| Terami, Takahiro| Higuchi, Chigusa| Katayama, Akihiro| Teshigawara, Sanae| Eguchi, Jun| Ogawa, Daisuke| Watanabe, Eijiro| Wada, Jun| Makino, Hirofumi| |
|---|---|
| Published Date | 2014-05-25 |
| Publication Title | PLOS ONE |
| Volume | volume9 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Ogawa, Daisuke| Eguchi, Jun| Wada, Jun| Terami, Naoto| Hatanaka, Takashi| Tachibana, Hiromi| Nakatsuka, Atsuko| Sato Horiguchi, Chikage| Nishii, Naoko| Makino, Hirofumi| |
|---|---|
| Published Date | 2014-01-22 |
| Publication Title | PLOS ONE |
| Volume | volume9 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Katayama, Akihiro| Nakatsuka, Atsuko| Eguchi, Jun| Murakami, Kazutoshi| Teshigawara, Sanae| Kanzaki, Motoko| Nunoue, Tomokazu| Hida, Kazuyuki| Wada, Nozomu| Yasunaka, Tetsuya| Ikeda, Fusao| Takaki, Akinobu| Yamamoto, Kazuhide| Kiyonari, Hiroshi| Makino, Hirofumi| Wada, Jun| |
|---|---|
| Published Date | 2015 |
| Publication Title | Scientific reports |
| Volume | volume5 |
| Content Type | Journal Article |
| Author | Kitamura, Shinji| Sakurai, Hiroyuki| Makino, Hirofumi| |
|---|---|
| Published Date | 2015-03 |
| Publication Title | Stem cells |
| Volume | volume33 |
| Issue | issue3 |
| Content Type | Journal Article |
| Title Alternative | Advances in Diabetology, The 49th Annual Post Graduate Course |
|---|---|
| FullText URL | 127_167.pdf |
| Author | Makino, Hirofumi| |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2015-08-03 |
| Volume | volume127 |
| Issue | issue2 |
| Start Page | 167 |
| End Page | 168 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.127.167 |
| language | 日本語 |
| Copyright Holders | Copyright (c) 2015 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.127.167 |
| NAID | 130005096244 |
| JaLCDOI | 10.18926/AMO/53117 |
|---|---|
| FullText URL | 69_1_1.pdf |
| Author | Watatani, Hiroyuki| Yamasaki, Hiroko| Maeshima, Yohei| Nasu, Tatsuyo| Hinamoto, Norikazu| Ujike, Haruyo| Sugiyama, Hitoshi| Sakai, Yoshiki| Tanabe, Katsuyuki| Makino, Hirofumi| |
| Abstract | Diabetic nephropathy is the most common pathological disorder predisposing patients to end-stage renal disease. Considering the increasing prevalence of type 2 diabetes mellitus worldwide, novel therapeutic approaches are urgently needed. ONO-1301 is a novel sustained-release prostacyclin analog that inhibits thromboxane A2 synthase. Here we examined the therapeutic effects of the intermittent administration of slow-release ONO-1301 (SR-ONO) on diabetic nephropathy in obese type 2 diabetes mice, as well as its direct effects on mesangial cells. The subcutaneous injection of SR-ONO (3mg/kg) every 3 wks did not affect the obesity or hyperglycemia in the db/db obese mice used as a model of type 2 diabetes, but it significantly ameliorated their albuminuria, glomerular hypertrophy, glomerular accumulation of type IV collagen, and monocyte/macrophage infiltration, and also the increase of TGF-β1, α-smooth muscle actin (α-SMA) and MCP-1 compared to vehicle treatment. In cultured mouse mesangial cells, ONO-1301 concentration-dependently suppressed the increases in TGF-β, type IV collagen, α-SMA, MCP-1 and fibronectin induced by high ambient glucose, at least partly through prostacyclin (PGI2) receptor-mediated signaling. Taken together, these results suggest the potential therapeutic efficacy of the intermittent administration of SR-ONO against type 2 diabetic nephropathy, possibly through protective effects on mesangial cells. |
| Keywords | prostacyclin ONO-1301 diabetic nephropathy TGF-β1 diabetes mellitus |
| Amo Type | Original Article |
| Published Date | 2015-02 |
| Publication Title | Acta Medica Okayama |
| Volume | volume69 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 1 |
| End Page | 15 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | 英語 |
| Copyright Holders | CopyrightⒸ 2015 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 25703166 |
| Web of Sience KeyUT | 000349740300001 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/53128 |
| Author | Tsuji, Kenji| Kitamura, Shinji| Makino, Hirofumi| |
|---|---|
| Published Date | 2014-04-25 |
| Publication Title | Biochemical and Biophysical Research Communications |
| Volume | volume447 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Terami, Takahiro| Wada, Jun| Inoue, Kentaro| Nakatsuka, Atsuko| Ogawa, Daisuke| Teshigawara, Sanae| Murakami, Kazutoshi| Katayama, Akihiro| Eguchi, Jun| Makino, Hirofumi| |
|---|---|
| Published Date | 2013-10-22 |
| Publication Title | International Journal of Nephrology and Renovascular Disease |
| Volume | volume6 |
| Content Type | Journal Article |
| Author | Inoue, Kentaro| Wada, Jun| Eguchi, Jun| Nakatsuka, Atsuko| Teshigawara, Sanae| Murakami, Kazutoshi| Ogawa, Daisuke| Terami, Takahiro| Katayama, Akihiro| Tone, Atsuhito| Iseda, Izumi| Hida, Kazuyuki| Yamada, Masao| Ogawa, Tomohisa| Makino, Hirofumi| |
|---|---|
| Published Date | 2013-10-15 |
| Publication Title | PLoS ONE |
| Volume | volume8 |
| Issue | issue10 |
| Content Type | Journal Article |
| Author | Nakayama, Kazunori| Nakao, Kazushi| Takatori, Yuji| Inoue, Junko| Kojo, Shoichirou| Akagi, Shigeru| Fukushima, Masaki| Wada, Jun| Makino, Hirofumi| |
|---|---|
| Published Date | 2013-12-18 |
| Publication Title | International Journal of Nephrology and Renovascular Disease |
| Volume | volume7 |
| Content Type | Journal Article |
| Author | Terasaka, Tomohiro| Otsuka, Fumio| Tsukamoto, Naoko| Nakamura, Eri| Inagaki, Kenichi| Toma, Kishio| Ogura-Ochi, Kanako| Glidewell-Kenney, Christine| Lawson, Mark A.| Makino, Hirofumi| |
|---|---|
| Published Date | 2013-12-05 |
| Publication Title | Molecular and Cellular Endocrinology |
| Volume | volume381 |
| Issue | issue1-2 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/52789 |
|---|---|
| FullText URL | 68_4_235.pdf |
| Author | Ono, Tetsuichiro| Shikata, Kenichi| Obika, Mikako| Miyatake, Nobuyuki| Kodera, Ryo| Hirota, Daisyo| Wada, Jun| Kataoka, Hitomi| Ogawa, Daisuke| Makino, Hirofumi| |
| Abstract | The aim of this study was to clarify the factors associated with the remission and/or regression of microalbuminuria in Japanese patients with type 2 diabetes mellitus. We retrospectively analyzed the data of 130 patients with type 2 diabetes mellitus with microalbuminuria for 2-6 years (3.39±1.31 years). Remission was defined as improving from microalbuminuria to normoalbuminuria using the albumin/creatinine ratio (ACR), and regression of microalbuminuria was defined as a decrease in ACR of 50% or more from baseline. Progression of microalbuminuria was defined as progressing from microalbuminuria to overt proteinuria during the follow-up period. Among 130 patients with type 2 diabetes mellitus with microalbuminuria, 57 and 13 patients were defined as having remission and regression, respectively, while 26 patients progressed to overt proteinuria. Sex (female), higher HDL cholesterol and lower HbA1c were determinant factors associated with remission/regression of microalbuminuria by logistic regression analysis. Lower systolic blood pressure (SBP) was also correlated with remission/regression, but not at a significant level. These results suggest that proper control of blood glucose, BP and lipid profiles may be associated with remission and/or regression of type 2 diabetes mellitus with microalbuminuria in clinical practice. |
| Keywords | microalbuminuria type 2 diabetes mellitus remission regression |
| Amo Type | Original Article |
| Published Date | 2014-08 |
| Publication Title | Acta Medica Okayama |
| Volume | volume68 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 235 |
| End Page | 241 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | 英語 |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 25145409 |
| Web of Sience KeyUT | 000340687500005 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/52828 |
| JaLCDOI | 10.18926/AMO/52788 |
|---|---|
| FullText URL | 68_4_219.pdf |
| Author | Hinamoto, Norikazu| Maeshima, Yohei| Saito, Daisuke| Yamasaki, Hiroko| Tanabe, Katsuyuki| Nasu, Tatsuyo| Watatani, Hiroyuki| Ujike, Haruyo| Kinomura, Masaru| Sugiyama, Hitoshi| Sonoda, Hikaru| Kanomata, Naoki| Sato, Yasufumi| Makino, Hirofumi| |
| Abstract | Experimental studies have demonstrated the involvement of angiogenesis-related factors in the progression of chronic kidney disease (CKD). There have so far been no reports investigating the distribution and clinical roles of Vasohibin-1 (VASH-1), a negative feedback regulator of angiogenesis, in CKD. We recruited 54 Japanese CKD patients and 6 patients who had normal renal tissues excised due to localized renal cell carcinoma. We evaluated the correlations between the renal expression level of VASH-1 and the clinical/histological parameters. VASH-1 was observed in renal endothelial/mesangial cells, crescentic lesions and interstitial inflammatory cells. Significant positive correlations were observed between 1) crescent formation and the number of VASH-1+ cells in the glomerulus (r＝0.48, p＝0.001) or cortex (r＝0.64, p＜0.0001), 2) interstitial cell infiltration and the number of VASH-1+ cells in the cortex (r＝0.34, p＝0.02), 3) the glomerular VEGFR-2+ area and the number of VASH-1+ cells in the glomerulus (r＝0.44, p＝0.01) or medulla (r＝0.63, p＝0.01). These results suggest that the renal levels of VASH-1 may be affected by local inflammation, crescentic lesions and VEGFR-2. |
| Keywords | chronic kidney disease inflammation Vasohibin-1 VEGF-A VEGFR-2 |
| Amo Type | Original Article |
| Published Date | 2014-08 |
| Publication Title | Acta Medica Okayama |
| Volume | volume68 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 219 |
| End Page | 233 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | 英語 |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 25145408 |
| Web of Sience KeyUT | 000340687500004 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/52824 |
| Author | Sugiyama, Koichi| Sada, Ken-ei| Kurosawa, Michiko| Wada, Jun| Makino, Hirofumi| |
|---|---|
| Published Date | 2013-02 |
| Publication Title | Clinical and Experimental Nephrology |
| Volume | volume17 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Kagawa, Hidetoshi| Hiromasa, Tsutomu| Hara, Takayuki| Takaki, Ayako| Yamanaka, Ryutaro| Sada, Ken-ei| Makino, Hirofumi| |
|---|---|
| Published Date | 2012-10 |
| Publication Title | Clinical and Experimental Nephrology |
| Volume | volume16 |
| Issue | issue5 |
| Content Type | Journal Article |
| Author | Kitagawa, Masashi| Sugiyama, Hitoshi| Morinaga, Hiroshi| Inoue, Tatsuyuki| Takiue, Keiichi| Ogawa, Ayu| Yamanari, Toshio| Kikumoto, Yoko| Uchida, Haruhito Adam| Kitamura, Shinji| Maeshima, Yohei| Nakamura, Kazufumi| Ito, Hiroshi| Makino, Hirofumi| |
|---|---|
| Published Date | 2013-02-19 |
| Publication Title | PLoS ONE |
| Volume | volume8 |
| Issue | issue2 |
| Content Type | Journal Article |
| Title Alternative | Cholecystokinin plays a novel protective role in diabetic kidney through anti-inflammatory actions on macrophages |
|---|---|
| FullText URL | 126_1.pdf |
| Author | Miyamoto, Satoshi| Shikata, Kenichi| Miyasaka, Kyoko| Okada, Shinichi| Sasaki, Motofumi| Kodera, Ryo| Hirota, Daisho| Kajitani, Nobuo| Takatsuka, Tetsuharu| Kataoka Usui, Hitomi| Nishishita, Shingo| Horiguchi Sato, Chikage| Funakoshi, Akihiro| Nishimori, Hisakazu| Uchida, Haruhito Adam| Ogawa, Daisuke| Makino, Hirofumi| |
| Keywords | cholecystokinin 糖尿病性腎症 抗炎症作用 腎保護効果 |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2014-04-01 |
| Volume | volume126 |
| Issue | issue1 |
| Start Page | 1 |
| End Page | 6 |
| ISSN | 0030-1558 |
| Related Url | http://www.okayama-u.ac.jp/user/oma/ |
| language | 日本語 |
| Copyright Holders | Copyright (c) 2014 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.126.1 |
