FullText URL fulltext.pdf
Author Katayama, Norihisa| Sato, Shuhei| Katsui, Kuniaki| Takemoto, Mitsuhiro| Tsuda, Toshihide| Yoshida, Atsushi| Morito, Tsuneharu| Nakagawa, Tomio| Mizutani, Akifumi| Waki, Takahiro| Niiya, Harutaka| Kanazawa, Susumu|
Keywords Breast cancer Breast-conserving surgery Radiotherapy Radiation-induced BOOP syndrome Endocrine therapy
Published Date 2009-03-15
Publication Title International journal of radiation oncology, biology, physics
Volume volume73
Issue issue4
Publisher Elsevier
Start Page 1049
End Page 1054
ISSN 0360-3016
NCID AA00680920
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version author
PubMed ID 18755559
DOI 10.1016/j.ijrobp.2008.05.050
Web of Science KeyUT 000264257400014
Related Url isVersionOf https://doi.org/10.1016/j.ijrobp.2008.05.050
JaLCDOI 10.18926/AMO/53521
FullText URL 69_3_145.pdf
Author Ishii, Hiroko| Kamikawa, Shigeshi| Hirohata, Satoshi| Mizutani, Akifumi| Abe, Koji| Seno, Masaharu| Oohashi, Toshitaka| Ninomiya, Yoshifumi|
Abstract Eosinophil cationic protein (ECP) is well known as a cationic protein contained in the basic granules of activated eosinophils. Recent studies have reported that ECP exhibits novel activities on various types of cells, including rat neonatal cardiomyocytes. Here we evaluated the effects of ECP on rat cardiac myoblast H9c2 cells. Our results showed that ECP enhanced the survival of the cells, in part by promoting the ERK and Akt/GSK-3β signaling pathways. ECP attenuated the cytotoxic effects of H2O2 on H9c2 cells as well as the production of reactive oxygen species, the number of apoptotic cells and caspase 3/7 activity in the cells. In conclusion, ECP activated the ERK and Akt/GSK-3β pathways, resulting in anti-oxidative effects on H9c2 cells that attenuated apoptosis.
Keywords ECP reactive oxygen species Akt ERK
Amo Type Original Article
Published Date 2015-06
Publication Title Acta Medica Okayama
Volume volume69
Issue issue3
Publisher Okayama University Medical School
Start Page 145
End Page 153
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2015 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 26101190
Web of Science KeyUT 000356903000003
FullText URL PLOSONE_9_9_e107976.pdf
Author Shigehiro, Tsukasa| Kasai, Tomonari| Murakami, Masaharu| Sekhar, Sreeja C.| Tominaga, Yuki| Okada, Masashi| Kudoh, Takayuki| Mizutani, Akifumi| Murakami, Hiroshi| Salomon, David S.| Mikuni, Katsuhiko| Mandai, Tadakatsu| Hamada, Hiroki| Seno, Masaharu|
Published Date 2014-09-29
Publication Title PLoS ONE
Volume volume9
Issue issue9
Publisher Public Library Science
Start Page e107976
ISSN 1932-6203
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version publisher
PubMed ID 25264848
DOI 10.1371/journal.pone.0107976
Web of Science KeyUT 000345745400036
Related Url isVersionOf https://doi.org/10.1371/journal.pone.0107976
FullText URL PLoSONE_7_4_e33544.pdf
Author Chen, Ling| Kasai, Tomonari| Li, Yueguang| Sugii, Yuh| Jin, Guoliang| Okada, Masashi| Vaidyanath, Arun| Mizutani, Akifumi| Satoh, Ayano| Kudoh, Takayuki| Hendrix, Mary J. C.| Salomon, David S| Fu, Li| Seno, Masaharu|
Published Date 2012-04-12
Publication Title PLoS ONE
Volume volume7
Issue issue4
ISSN 1932-6203
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version publisher
PubMed ID 22511923
DOI 10.1371/journal.pone.0033544
Web of Science KeyUT 000305338600009
Related Url isVersionOf https://doi.org/10.1371/journal.pone.0033544