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ID 34232
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Author
Matsuura, Hiroko
Hina, Kazuyoshi
Yamamoto, Keizo
Kawamura, Hiroshi
Sogo, Taiji
Abstract

Objectives: To investigate the relationship between the plasma B-type natriuretic peptide (BNP) level and the occurrence of atrial fibrillation (AF) in nonobstructive hypertrophic cardiomyopathy (HCM) patients.
Methods: Patients (n=97) were classified into chronic AF (CAF; n=14), paroxysmal AF (PAF; n=18) and normal sinus rhythm (NSR; n=65) groups. The plasma BNP values were analyzed with logarithmic transformation.
Results: The PAF group showed significantly higher plasma BNP levels than the NSR group [mean (range; -1 SD and +1 SD); 248.3 (143.5, 429.5) vs. 78.2 (27.9, 218.8 ng/L), p<0.0001]. The CAF group also showed significantly higher plasma BNP levels than the NSR group [291.1 (161.4, 524.8 ng/L), p<0.0001]. Multivariate analysis with other clinical factors selected association of PAF as one of the factors that increased the plasma BNP level.
Conclusions: The present study indicated that plasma BNP level is clinically useful for identification of nonobstructive HCM patients who have a risk of PAF.

Keywords
clinical study
cardiomyopathy
tachyarrhythmia
enzyme immunoassay
peptide
sensitivity and specificity
Note
Published with permission from the copyright holder.
This is a author's copy,as published in Clinical Biochemistry , 2008 Vol.41 Issue.3 pp.134-139
Publisher URL: http://dx.doi.org/10.1016/j.clinbiochem.2007.10.015
Direct access to Thomson Web of Science record
Copyright © The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
Published Date
2008-02
Publication Title
Clinical Biochemistry
Volume
volume41
Issue
issue3
Publisher
Elsevier Inc.
Start Page
134
End Page
139
ISSN
0009-9120
NCID
AA00607603
Content Type
Journal Article
language
英語
Copyright Holders
The Canadian Society of Clinical Chemists. Published by Elsevier Inc.
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author
Refereed
True
DOI
PubMed ID
Web of Sience KeyUT
Submission Path
biochemistry/12