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ID 30802
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Author
Kimura, Nobuhiko
Nishioka, Keiko
Nishizaki, Kazunori Kakenhi
Ogawa, Teruhiro
Naitou, Yoshihiro
Masuda, Yu
Abstract

 We studied the clinical efficacy of roxithromycin (RXM) administered at the daily dosage of one tablet (150mg) for 3 months in 30 patients with chronic sinusitis. The effectiveness of this drug was evaluated on a four-point scale. Subjective and objective symptoms disappeared or decreased markedly, especially postnasal drip and nature of discharge in 80 percent or more of the patients. All symptoms significantly decreased (P < 0.001; headache P < 0.05), except for the sensation of foul odor. Symptoms improved even in those cases in which Haemophilus influenzae was detected. It is suggested that RXM produces some clinically beneficial effect through an immunological and or anti-inflammatory mechanisms in addition to its antibiotic effect.

Keywords
roxithromycin
clinical evaluation
chronic sinusitis
long-term
low-dose administration
Amo Type
Article
Published Date
1997-02
Publication Title
Acta Medica Okayama
Volume
volume51
Issue
issue1
Publisher
Okayama University Medical School
Start Page
33
End Page
37
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
File Version
publisher
Refereed
True
PubMed ID
Web of Sience KeyUT