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ID 57583
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Author
Makihara, Seiichiro Department of Otolaryngology-Head & Neck Surgery, Kagawa Rosai Hospital
Kariya, Shin Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID
Noujima-Harada, Mai Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,
Ohara, Nobuya Department of Pathology, Kagawa Rosai Hospital
Naito, Tomoyuki Department of Otolaryngology-Head & Neck Surgery, Kagawa Rosai Hospital
Matsumoto, Junya Department of Otolaryngology-Head & Neck Surgery, Kagawa Rosai Hospital
Noda, Yohei Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Okano, Mitsuhiro Department of Otolaryngology, International University of Health and Welfare School of Medicine
Yoshino, Tadashi Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Kaken ID
Nishizaki, Kazunori Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID
Abstract
As has been well recognized, methotrexate (MTX) leads to a state of immunosuppression and can provide a basis for the development of lymphoproliferative disorders (LPDs). MTX-associated LPDs can affect nodal sites as well as extranodal sites, though the manifestation of an LPD in the form of multiple pulmonary nodules is rare. Here, we report two cases of MTX-associated LPD with multiple bilateral pulmonary nodules, which was a finding suggestive of lung cancer, and bilateral cervical lymphadenopathy. After withdrawal of MTX, the multiple bilateral pulmonary nodules and bilateral cervical lymphadenopathy disappeared without chemotherapy in both cases. From these results, patients with pulmonary nodules and cervical lymphadenopathy should be examined for head and neck malignant tumors. Also, physicians should carefully check the administration of MTX. In patients with an MTX-associated LPD, we need to make an early diagnosis and consider discontinuing the administration of MTX as soon as possible.
Keywords
MTX-associated LPD
Methotrexate
Pulmonary nodules
Note
This fulltext will be available in Aug 2020
Published Date
2019-12-31
Publication Title
Auris Nasus Larynx
Volume
volume46
Issue
issue6
Publisher
Elsevier
Start Page
927
End Page
933
ISSN
03858146
NCID
AA00061157
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
Copyright Holders
© 2019 Elsevier B.V. All rights reserved.
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author
PubMed ID
DOI
Web of Science KeyUT
Related Url
isVersionOf https://doi.org/10.1016/j.anl.2019.01.010
License
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
Citation
Seiichiro Makihara, Shin Kariya, Mai Noujima-Harada, Nobuya Ohara, Tomoyuki Naito, Junya Matsumoto, Yohei Noda, Mitsuhiro Okano, Tadashi Yoshino, Kazunori Nishizaki, Methotrexate-associated lymphoproliferative disorder with multiple pulmonary nodules and bilateral cervical lymphadenopathy, Auris Nasus Larynx, Volume 46, Issue 6, 2019, Pages 927-933, ISSN 0385-8146, https://doi.org/10.1016/j.anl.2019.01.010.
Funder Name
Ministry of Education, Culture, Sports, Science and Technology
助成番号
JP16K20249
Open Access (Publisher)
non-OA
Open Archive (publisher)
Non-OpenArchive