JaLCDOI 10.18926/AMO/51072
FullText URL 67_4_265.pdf
Author Hanakawa, Hiroyuki| Orita, Yorihisa| Sato, Yasuharu| Uno, Kinya| Nishizaki, Kazunori| Yoshino, Tadashi|
Abstract We present a case of a 67-year-old Japanese man with a serious oropharyngeal ulceration that at first seemed to be destructive malignant lymphoma or oropharyngeal carcinoma. We suspected methotrexate (MTX)-associated lymphoproliferative disorder (LPD) induced by MTX treatment for rheumatoid arthritis (RA). About 3 weeks after simple discontinuation of MTX, complete regression of the disease was observed, confirming our diagnosis.
Keywords ulceration methotrexate oropharynx lymphoproliferative disorders
Amo Type Case Report
Published Date 2013-08
Publication Title Acta Medica Okayama
Volume volume67
Issue issue4
Publisher Okayama University Medical School
Start Page 265
End Page 269
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2013 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 23970326
Web of Science KeyUT 000323470100009
Author Higaki, T| Okano, M| Fujiwara, T| Makihara, S| Kariya, S| Noda, Y| Haruna, T| Nishizaki, K|
Published Date 2012-08
Publication Title Clinical and Experimental Allergy
Volume volume42
Issue issue8
Content Type Journal Article
Author Nishizaki, Kazunori|
Published Date 2012-12-03
Publication Title 岡山医学会雑誌
Volume volume124
Issue issue3
Content Type Article
Author Kataoka, Yuko| Fukushima, Kunihiro| Sugaya, Akiko| Nishizaki, Kazunori|
Published Date 2012-08-01
Publication Title 岡山医学会雑誌
Volume volume124
Issue issue2
Content Type Journal Article
Author Kawasaki, Akihiro| Fukushima, Kunihiro| Kataoka, Yuko| Fukuda, Shoichiro| Nishizaki, Kazunori|
Published Date 2006-8
Publication Title International Journal of Pediatric Otorhinolaryngology
Volume volume70
Issue issue8
Content Type Journal Article
Author Kariya, Shin| Nishizaki, kazunori| Akagi, Hirofumi| Paparella, Michael M.|
Published Date 2004-11
Publication Title Journal of Laryngology & Otology
Volume volume118
Issue issue11
Content Type Journal Article
JaLCDOI 10.18926/AMO/32301
FullText URL fulltext.pdf
Author Endo, Ryutaro| Murakami, Shinichiro| Masuda, Yu| Taguchi, Takehito| Ohtsuka, Aiji| Nishizaki, Kazunori| Murakami, Takuro|
Abstract <p>The present study showed that many neurons in the adult rat brain possessed a perineuronal sulfated proteoglycan surface coat which reacted to cationic iron colloid and aldehyde fuchsin. This surface coat was stained supravitally with Ehrlich's methylene blue and doubly stained with Ehrlich's methylene blue and aldehyde fuchsin. The surface coat was also stained with Gomori's ammoniacal silver and doubly stained with Gomori's ammoniacal silver and cationic iron colloid. The surface coat was usually expressed together with a nerve cell surface glycoprotein net detectable with lectin Wisteria floribunda agglutinin. These findings indicate that the perineuronal proteoglycan surface coat is identical to Cajal's superficial reticulum and contains some collagenous elements. It was further demonstrated that collagenase digestion erased Gomori's ammoniacal silver impregnation within the perineuronal proteoglycan surface coat.</p>
Keywords brain extracellular matrix perineuronal proteoglycans cell surface glycoproteins
Amo Type Article
Published Date 2000-06
Publication Title Acta Medica Okayama
Volume volume54
Issue issue3
Publisher Okayama University Medical School
Start Page 111
End Page 118
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 10925735
Web of Science KeyUT 000087965700003
JaLCDOI 10.18926/AMO/30802
FullText URL fulltext.pdf
Author Kimura, Nobuhiko| Nishioka, Keiko| Nishizaki, Kazunori| Ogawa, Teruhiro| Naitou, Yoshihiro| Masuda, Yu|
Abstract <p>&#8195;We studied the clinical efficacy of roxithromycin (RXM) administered at the daily dosage of one tablet (150mg) for 3 months in 30 patients with chronic sinusitis. The effectiveness of this drug was evaluated on a four-point scale. Subjective and objective symptoms disappeared or decreased markedly, especially postnasal drip and nature of discharge in 80 percent or more of the patients. All symptoms significantly decreased (P &#60; 0.001; headache P &#60; 0.05), except for the sensation of foul odor. Symptoms improved even in those cases in which Haemophilus influenzae was detected. It is suggested that RXM produces some clinically beneficial effect through an immunological and or anti-inflammatory mechanisms in addition to its antibiotic effect.</p>
Keywords roxithromycin clinical evaluation chronic sinusitis long-term low-dose administration
Amo Type Article
Published Date 1997-02
Publication Title Acta Medica Okayama
Volume volume51
Issue issue1
Publisher Okayama University Medical School
Start Page 33
End Page 37
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 9057933
Web of Science KeyUT A1997WL24600006
JaLCDOI 10.18926/AMO/30796
FullText URL fulltext.pdf
Author Miyahara, Satoko| Nakada, Michihiro| Nishizaki, Kazunori| Kawarai, Yasuyuki| Nishioka, Keiko| Hino, Hiroo|
Abstract <p>We studied 92 patients with allergic rhinitis in Syodoshima, Japan, during the pollen season between April and June to evaluate the cross-reactivity to different antigens, including pollen from the olive tree (Olea europaea) and orchard grass (Dactylis glomerata). Olive tree pollen was present in the atmosphere for 23 days, from May 19 to June 12, 1994. Specific IgE antibodies for olive tree pollen antigen were present in 21 (26.9%) of the 78 patients with allergic rhinitis. Nine (24.3%) of the 37 patients with allergic rhinitis exhibited positive skin reactivity to an extract of olive tree pollen. Fifteen (88.2 %) of the 17 patients who had IgE reactivity in their sera to olive tree pollen antigen demonstrated allergic reactions to an extract of olive tree pollen. Specific IgE antibodies for orchard grass pollen antigen were present in 43 (48.3%) of the 89 patients with allergic rhinitis and 20 (95.2%) of the 21 patients who had IgE reactivity in their sera to olive tree pollen antigen. The inhibition test using the CAP System revealed that the reactivity of the IgE antibody specific for olive tree pollen antigen was inhibited dose-dependently by an extract of orchard grass pollen. These findings show that there is a reaction in some patients with grass (Gramineae) pollinosis that might be induced by olive tree pollen.</p>
Keywords olive tree pollen pollinosis cross-reactivity grass pollen orchard grass
Amo Type Article
Published Date 1997-06
Publication Title Acta Medica Okayama
Volume volume51
Issue issue3
Publisher Okayama University Medical School
Start Page 167
End Page 171
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 9227797
Web of Science KeyUT A1997XJ12700009
JaLCDOI 10.18926/AMO/30655
FullText URL fulltext.pdf
Author Nishioka, Keiko| Masuda, Yu| Nishizaki, Kazunori| Ogura, Yoshio|
Abstract <p>Unilateral cystic inner ear anomalies were diagnosed in two siblings, a 9 year old boy and a 6 year old girl. X-ray examination of the temporal bone was performed, together with audiological examinations and vestibular function tests. The common tomographic X-ray findings consisted of an enlarged solitary sac type deformity of the vestibule with narrowing of the internal auditory canal, severe hypoplasia of the anterior semicircular canal and no visualized cochlea. Pure-tone audiometry revealed severe mixed type of hearing loss in the right ear in both children. The test for vestibular function showed no response to caloric testing.</p>
Keywords inner ear anomaliy siblings
Amo Type Brief Note
Published Date 1982-08
Publication Title Acta Medica Okayama
Volume volume36
Issue issue4
Publisher Okayama University Medical School
Start Page 321
End Page 324
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 7136861
Web of Science KeyUT A1982PE61100011
JaLCDOI 10.18926/AMO/30373
FullText URL fulltext.pdf
Author Okada, Satoko| Ohtsuka, Aiji| Akagi, Hirofumi| Nishizaki, Kazunori| Masuda, Yu|
Abstract <p>It has previously been confirmed that the guinea pig has aggregations of 10-20 lymphoid follicles at the junction of the nasal cavity and the nasopharyngeal duct. The vascular architecture of this nasal-associated lymphoid tissue (NALT) was studied by the corrosion cast/scanning electron microscope method. The NALT was supplied by branches of the inferior nasal artery. These afferent arterial branches gave off arterioles to the follicles and the interfollicular regions, where the arterioles ramified into capillaries. Some of these arterioles reached the subepithelial region to form a single-layer dense capillary network. The subepithelial capillaries gathered into short collecting venules, which in turn drained into high endothelial venules (HEV) in the interfollicular region. The HEV, which also receives tributaries from the follicular and interfollicular capillary plexuses, descended in the interfollicular regions and finally flowed into the efferent veins at the bottom of the NALT. Indentations impressed by high endothelial cells (HEC) were prominent on the surface of the HEV casts, and their frequency was larger in the upper course or segments than in the lower. This suggests that the incidence of HEC in the upper segments is higher than in the lower segments, and these findings are consistent with the hypothesis that some substances which are taken up into the subepithelial capillaries and transported to the venules induce differentiation and maintain of HEVs.</p>
Keywords nasal-associated lymphoid tisse vascular corrosion cast microvascular architecture high endothelial venule guinea pig
Amo Type Article
Published Date 1995-08
Publication Title Acta Medica Okayama
Volume volume49
Issue issue4
Publisher Okayama University Medical School
Start Page 213
End Page 219
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 7502682
Web of Science KeyUT A1995RR97800006
Author Takahara, Shigeo| Ogura, Yoshio| Masuda, Yu| Nishioka, Keiko| Nishizaki, Kazunori| Sugiura, Tomoaki| Furukawa, Katsuro| Mizuko, Yukio| Kuroda, Yasuo| Ogata, Masana| Ohkura, Koji|
Published Date 1986-06-30
Publication Title 岡山医学会雑誌
Volume volume98
Issue issue5-6
Content Type Journal Article
Author Nomiya, Rie| Okano, Mitsuhiro| Fujiwara, Tazuko| Nishizaki, Kazunori|
Published Date 2009-08-03
Publication Title 岡山医学会雑誌
Volume volume121
Issue issue2
Content Type Journal Article