Fu, Liyan Graduate School of Natural Science and Technology, Okayama University
Chen, Qiang Graduate School of Natural Science and Technology, Okayama University
Wang, Zhenhua Graduate School of Natural Science and Technology, Okayama University
Palladium-catalyzed decarbonylative alkylation reactions of acyl fluorides have been developed using alkylboranes having β-hydrogens. A wide range of functional groups were well tolerated, even at the high temperature required for decarbonylation. This protocol provides a diverse C(sp2)–C(sp3) bond formation via a highly efficient decarbonylative process. The hemilabile bidentate ligand DPPE plays a crucial role for retardation of the undesired β-hydride elimination.
This document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in Organic Letters, copyright © American Chemical Society after peer review. To access the final edited and published work see https://doi.org/10.1021/acs.orglett.0c00542. This fulltext is available in May 2021.
American Chemical Society
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