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ID 33023
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Author
Tsunamoto, Yumi
Komagoe, Keiko
Masuda, Kazufumi
Abstract
S,S,S-Tris(2-ethylhexyl) phosphorotrithioate proved to be an effective solvent mediator for constructing a mexiletine-sensitive membrane electrode in combination with an ion-exchanger, sodium tetrakis[3,5-bis(2-methoxyhexafluoro-2-propyl)phenyl]borate. Among a series of phosphorus compounds containing phosphoryl (P=O) groups, this solvent mediator showed the highest sensitivity to mexiletine in phosphate-buffered physiological saline containing 0.15 mol L-1 NaCl and 0.01 mol L-1 NaH2PO4/Na2HPO4 (pH 7.4), giving a detection limit of 2 x 10(-6) mol L-1 with a slope of 58.8 mV decade(-1). This is the best reported detection limit of any mexiletine-sensitive electrode developed to date. Owing to its high selectivity toward inorganic cations, the electrode was used to determine the level of mexiletine in saliva, the monitoring of which is quite effective for controlling the dose of this drug noninvasively. The mexiletine concentrations determined with the mexiletine-sensitive electrode compared favorably with those determined by high-performance liquid chromatography.
Keywords
Ion-selective electrode
Mexiletine determination
S,S,S-Tris(2-ethylhexyl) phosphorotrithioate
Solvent mediator
Drug monitoring
Note
Published with permission from the copyright holder.
This is published in Analytical and Bioanalytical Chemistry, 2007 Vol.387 Issue.6 pp.2057-2064
Publisher URL: http://dx.doi.org/10.1007/s00216-006-1105-y
Direct access to Thomson Web of Science record
(C)2007 Springer-Verlag.
Published Date
2007-03
Publication Title
Analytical and Bioanalytical Chemistry
Volume
volume387
Issue
issue6
Publisher
Springer Berlin / Heidelberg
Start Page
2057
End Page
2064
ISSN
1618-2642
NCID
AA00524787
Content Type
Journal Article
language
英語
Copyright Holders
Springer-Verlag
File Version
author
Refereed
True
DOI
Web of Science KeyUT
Submission Path
analytical_chemistry/42