Title Alternative | Okayama University Hospital as a Clinical Core Hospital |
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FullText URL | 126_231.pdf |
Author | Nasu, Yasutomo| |
Keywords | メガホスピタル ICH-GCP 治験 臨床研究 |
Publication Title | 岡山医学会雑誌 |
Published Date | 2014-12-01 |
Volume | volume126 |
Issue | issue3 |
Start Page | 231 |
End Page | 235 |
ISSN | 0030-1558 |
language | 日本語 |
Copyright Holders | Copyright (c) 2014 岡山医学会 |
File Version | publisher |
DOI | 10.4044/joma.126.231 |
NAID | 130004903240 |
Author | 那須 保友| |
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Published Date | 1986-03-31 |
Publication Title | |
Content Type | Thesis or Dissertation |
Author | Nasu, Yasutomo| |
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Published Date | 2016-12-01 |
Publication Title | Journal of Okayama Medical Association |
Volume | volume128 |
Issue | issue3 |
Content Type | Journal Article |
Author | Nasu, Yasutomo| |
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Published Date | 2011-08-01 |
Publication Title | 岡山医学会雑誌 |
Volume | volume123 |
Issue | issue2 |
Content Type | Journal Article |
Title Alternative | Development of artificial intelligence (AI) in medical field |
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Author | Nasu, Yasutomo| |
Publication Title | Journal of Okayama Medical Association |
Published Date | 2020-08-03 |
Volume | volume132 |
Issue | issue2 |
Start Page | 91 |
End Page | 91 |
ISSN | 0030-1558 |
Related Url | isVersionOf https://doi.org/10.4044/joma.132.91 |
language | 日本語 |
Copyright Holders | Copyright (c) 2020 岡山医学会 |
File Version | publisher |
DOI | 10.4044/joma.132.91 |
NAID | 130007894958 |
Author | 那須 保友| 公文 裕巳| |
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Published Date | 2002-09-30 |
Publication Title | 岡山医学会雑誌 |
Volume | volume114 |
Issue | issue2 |
Content Type | Journal Article |
Author | Nasu, Yasutomo| |
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Published Date | 2008-08-01 |
Publication Title | 岡山医学会雑誌 |
Volume | volume120 |
Issue | issue2 |
Content Type | Journal Article |
Author | Kobuke, Makoto| Nasu, Yasutomo| Kumon, Hiromi| |
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Published Date | 2008-08-01 |
Publication Title | 岡山医学会雑誌 |
Volume | volume120 |
Issue | issue2 |
Content Type | Journal Article |
JaLCDOI | 10.18926/AMO/32875 |
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FullText URL | fulltext.pdf |
Author | Namba, Yuzaburo| Sugiyama, Narushi| Yamashita, Shuji| Hasegawa, Kenjiro| Kimata, Yoshihiro| Ishii, Kazushi| Nasu, Yasutomo| |
Abstract | <p>To date, many techniques have been reported for vaginoplasty in male-to-female trans-sexual (MTFTS) patients, such as the use of a rectum transfer, a penile-scrotal flap and a reversed penile flap. However, none of these procedures is without its disadvantages. We developed a newly kind of flap for vaginoplasty, the M-shaped perineo-scrotal flap (M-shaped flap), using skin from both sides of the scrotum, shorn of hair by preoperative laser treatment. We applied this new type of flap in 7 MTFTS patients between January 2006 and January 2007. None of the flaps developed necrosis, and the patients could engage in sexual activity within 3 months of the operation. The M-shaped flap has numerous advantages: it can be elevated safely while retaining good vascularity, it provides for the construction of a sufficient deep vagina without a skin graft, the size of the flap is not influenced entirely by the length of the penis, and it utilizes skin from both sides of the scrotal area, which is usually excised.</p> |
Keywords | vaginoplasty male-to-female transsexual perineo-scrotal flap |
Amo Type | Original Article |
Published Date | 2007-12 |
Publication Title | Acta Medica Okayama |
Volume | volume61 |
Issue | issue6 |
Publisher | Okayama University Medical School |
Start Page | 355 |
End Page | 360 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | 英語 |
File Version | publisher |
Refereed | True |
PubMed ID | 18183081 |
Web of Science KeyUT | 000251943800007 |
JaLCDOI | 10.18926/AMO/32084 |
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FullText URL | fulltext.pdf |
Author | Abarzua, Fernando| Monden, Koichi| Nagai, Atsushi| Nasu, Yasutomo| Kumon, Hiromi| |
Abstract | <p>Ureteroscopy has evolved in many aspects, particularly in the flexibility and size of ureteroscopes. We have developed a new detachable access sheath to make ureteroscopic procedures more straight-forward and to reduce possible damage to delicate instruments used in the procedure.</p> |
Keywords | ureteroscopy detachable accesss heath |
Amo Type | Article |
Published Date | 2004-08 |
Publication Title | Acta Medica Okayama |
Volume | volume58 |
Issue | issue4 |
Publisher | Okayama University Medical School |
Start Page | 215 |
End Page | 216 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | 英語 |
File Version | publisher |
Refereed | True |
PubMed ID | 15551759 |
Web of Science KeyUT | 000223559700006 |
Author | Ochiai, Kazuhiko| Watanabe, Masami| Ueki, Hideo| Huang, Peng| Fujii, Yasuyuki| Nasu, Yasutomo| Noguchi, Hirofumi| Hirata, Takeshi| Sakaguchi, Masakiyo| Huh, Nam-ho| Kashiwakura, Yuji| Kaku, Haruki| Kumon, Hiromi| |
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Published Date | 2011-08-26 |
Publication Title | Biochemical and Biophysical Research Communications |
Volume | volume412 |
Issue | issue2 |
Content Type | Journal Article |
JaLCDOI | 10.18926/AMO/54507 |
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FullText URL | 70_4_295.pdf |
Author | Araki, Motoo| Wada, Koichiro| Mitsui, Yosuke| Kubota, Risa| Yoshioka, Takashi| Ariyoshi, Yuichi| Kobayashi, Yasuyuki| Kitagawa, Masashi| Tanabe, Katsuyuki| Sugiyama, Hiroshi| Wada, Jun| Watanabe, Masami| Watanabe, Toyohiko| Hotta, Katsuyuki| Nasu, Yasutomo| |
Abstract | Although graft survival following renal transplantation (RTx) has improved, outcomes following highrisk RTx are variable. Preexisting antibodies, including donor-specific antibodies (DSA), play an important role in graft dysfunction and survival. We have designed a study to investigate the safety and efficacy of anti-CD20 monoclonal antibodies (rituximab) in high-risk RTx recipients. Major eligibility criteria include: 1) major and minor ABO blood group mismatch, 2) positive DSA. Thirty-five patients will receive 200 mg/body of rituximab. The primary endpoint is the incidence of B cell depletion. This study will clarify whether rituximab is efficacious in improving graft survival in high-risk RTx recipients. |
Keywords | end-stage renal disease immunosuppression kidney transplantation |
Amo Type | Clinical Study Protocols |
Published Date | 2016-08 |
Publication Title | Acta Medica Okayama |
Volume | volume70 |
Issue | issue4 |
Publisher | Okayama University Medical School |
Start Page | 295 |
End Page | 297 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | 英語 |
Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 27549676 |
Web of Science KeyUT | 000384748600011 |
JaLCDOI | 10.18926/AMO/32878 |
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FullText URL | fulltext.pdf |
Author | Ebara, Shin| Manabe, Daisuke| Kobayashi, Yasuyuki| Tanimoto, Ryuta| Saika, Takashi| Nasu, Yasutomo| Saito, Shirou| Satoh, Takefumi| Miki, Kenta| Hashine, Katsuyoshi| Kumon, Hiromi| |
Abstract | <p>From September 2003 to December 2005, 188 patients who visited our hospital and allied institutions for the purpose of prostate brachytherapy were administrated hormonal therapy for volume reductions before brachytherapy. The pretreatment and posttreatment of prostate volume using a transrectal ultrasound volumetric study and the types and duration of hormonal therapy were analyzed. We administered 91 patients with Luteinizing hormone-releasing hormone (LH-RH) agonist, 49 patients with anti-androgen (bicaltamide/flutamide), and 48 patients with maximum androgen blockade (MAB). The duration of the hormonal therapy was 1-3 months for 49 patients, 4-6 months for 59 patients, 7-9 months for 40 patients, 10-12 months for 32 patients, and over 13 months for 8 patients. Before the initiation of hormonal therapy, the mean prostate volume was 35.12 ml (11.04-78.71 ml), and the average of prostate volume before and after hormonal therapy was 36.79 ml and 24.79 ml, respectively (a 32.4% reduction). The prostate volume reduction rate was 32.0% for the LH-RH agonist only, 18.1% for the anti-androgen only and 41.2% for the MAB. No statistically significant difference was observed for the duration of hormonal therapy between 3 groups. A three-month course of the neoadjuvant LH-RH agonist indicated a sufficient volume reduction effectiveness for a large prostate volume.</p> |
Keywords | androgen deprivation therapy brachytherapy localized prostate cancer prostate volume reduction |
Amo Type | Original Article |
Published Date | 2007-12 |
Publication Title | Acta Medica Okayama |
Volume | volume61 |
Issue | issue6 |
Publisher | Okayama University Medical School |
Start Page | 335 |
End Page | 340 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | 英語 |
File Version | publisher |
Refereed | True |
PubMed ID | 18183078 |
Web of Science KeyUT | 000251943800004 |
JaLCDOI | 10.18926/AMO/54982 |
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FullText URL | 71_2_135.pdf |
Author | Mori, Akihiro| Watanabe, Masami| Sadahira, Takuya| Kobayashi, Yasuyuki| Ariyoshi, Yuichi| Ueki, Hideo| Wada, Koichiro| Ochiai, Kazuhiko| Li, Shun-Ai| Nasu, Yasutomo| |
Abstract | The cluster of differentiation 147 (CD147), also known as EMMPRIN, is a key molecule that promotes cancer progression. We previously developed an adenoviral vector encoding a tumor suppressor REIC/Dkk-3 gene (Ad-REIC) for cancer gene therapy. The therapeutic effects are based on suppressing the growth of cancer cells, but, the underlying molecular mechanism has not been fully clarified. To elucidate this mechanism, we investigated the effects of Ad-REIC on the expression of CD147 in LNCaP prostate cancer cells. Western blotting revealed that the expression of CD147 was significantly suppressed by Ad-REIC. Ad-REIC also suppressed the cell growth of LNCaP cells. Since other researchers have demonstrated that phosphorylated mitogen-activated protein kinases (MAPKs) and c-Myc protein positively regulate the expression of CD147, we investigated the correlation between the CD147 level and the activation of MAPK and c-Myc expression. Unexpectedly, no positive correlation was observed between CD147 and its possible regulators, suggesting that another signaling pathway was involved in the downregulation of CD147. This is the first study to show the downregulation of CD147 by Ad-REIC in prostate cancer cells. At least some of the therapeutic effects of Ad-REIC may be due to the downregulation of the cancer-progression factor, CD147. |
Keywords | prostate cancer REIC/Dkk-3 CD147 cell growth p38 MAP kinase |
Amo Type | Original Article |
Published Date | 2017-04 |
Publication Title | Acta Medica Okayama |
Volume | volume71 |
Issue | issue2 |
Publisher | Okayama University Medical School |
Start Page | 135 |
End Page | 142 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | 英語 |
Copyright Holders | CopyrightⒸ 2017 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 28420895 |
JaLCDOI | 10.18926/AMO/30939 |
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FullText URL | fulltext.pdf |
Author | Kobayashi, Yasuyuki| Saika, Takashi| Manabe, Daisuke| Nasu, Yasutomo| Kumon, Hiromi| |
Abstract | <p>The purpose of this study is to compare the performance of laparoscopic partial nephrectomy (LPN) with and without clamping of the renal artery and to evaluate the impact of clamping on postoperative renal function. A total of 20 patients underwent LPN, 13 without and 7 with clamping of the renal artery. The 2 groups were compared with respect to complications, blood loss, operative time, mean tumor size, and incidence of positive margins. Renal function was evaluated by pre- and postoperative renal scintigraphy using <sup>99m</sup>Technetium-mercaptoacetyltriglycine (<sup>99m</sup>Tc-MAG3). Intraoperative blood loss was significantly higher in the group without clamping than in the group with clamping (p0.04). In the group with clamping, the median warm ischemic time was 35min (range 25-40min). The serum creatinine values and the renal scintigraphy showed no influence on postoperative renal function with or without clamping. In the group without clamping, 2 cases were showed positive surgical margins. The procedure performed with clamping of the renal artery is superior to the procedure performed without clamping as it provides the advantages of controlling hemorrhaging without injury to renal function and prolonging the surgical time and allowing for more accurate resection of renal tumors.</p> |
Keywords | laparoscopic partial nephrectomy <sup>99m</sup>Tc-MAG3 renal function |
Amo Type | Original Article |
Published Date | 2008-08 |
Publication Title | Acta Medica Okayama |
Volume | volume62 |
Issue | issue4 |
Publisher | Okayama University Medical School |
Start Page | 269 |
End Page | 273 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | 英語 |
File Version | publisher |
Refereed | True |
PubMed ID | 18766210 |
Web of Science KeyUT | 000258680900007 |
Author | Kurahashi, Hiroaki| Watanabe, Masami| Sugimoto, Morito| Ariyoshi, Yuichi| Mahmood, Sabina| Araki, Motoo| Ishii, Kazushi| Nasu, Yasutomo| Nagai, Atsushi| Kumon, Hiromi| |
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Published Date | 2013-12 |
Publication Title | Endocrine Journal |
Volume | volume60 |
Issue | issue12 |
Content Type | Journal Article |
JaLCDOI | 10.18926/AMO/47013 |
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FullText URL | 65_5_315.pdf |
Author | Wang, Lei| Kaku, Haruki| Huang, Peng| Xu, Kexin| Yang, Kai| Zhang, Jiheng| Li, Ming| Xie, Liping| Wang, Xiaofeng| Sakai, Akiko| Watanabe, Masami| Nasu, Yasutomo| Shimizu, Kenji| Kumon, Hiromi| Na, Yanqun| |
Abstract | Deficiencies in the human DNA repair gene WRN are the cause of Werner syndrome, a rare autosomal recessive disorder characterized by premature aging and a predisposition to cancer. This study evaluated the association of WRN Leu1074Phe (rs1801195), a common missense single nucleotide polymorphism in WRN, with prostate cancer susceptibility in Chinese subjects. One hundred and forty-seven prostate cancer patients and 111 male cancer-free control subjects from 3 university hospitals in China were included. Blood samples were obtained from each subject, and the single nucleotide polymorphism WRN Leu1074Phe was genotyped by using a Snapshot assay. The results showed that WRN Leu1074Phe was associated with the risk of prostate cancer in Chinese men and that the TG/GG genotype displayed a decreased prevalence of prostate cancer compared with the TT genotype (OR=0.58, 95%CI:0.35-0.97, p=0.039). Through stratified analysis, more significant associations were revealed for the TG/GG genotype in the subgroup with diagnosis age <_ 72 yr (OR=0.27, 95%CI:0.12-0.61, p=0.002) and in patients with localized diseases (OR=0.36, 95%CI:0.19-0.70, p=0.003). However, no statistically significant difference was found in the subgroup with age >72 yr or in patients with advanced diseases. We concluded that the genetic variant Leu1074Phe in the DNA repair gene WRN might play a role in the risk of prostate cancer in Chinese subjects. |
Keywords | polymorphism prostatic neoplasms single nucleotide susceptibility WRN |
Amo Type | Original Article |
Published Date | 2011-10 |
Publication Title | Acta Medica Okayama |
Volume | volume65 |
Issue | issue5 |
Publisher | Okayama University Medical School |
Start Page | 315 |
End Page | 323 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | 英語 |
Copyright Holders | CopyrightⒸ 2011 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 22037267 |
Web of Science KeyUT | 000296116400005 |
JaLCDOI | 10.18926/AMO/31976 |
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FullText URL | fulltext.pdf |
Author | Nagai, Atsushi| Tokuyama, Eijirou| Nanba, Yuzaburo| Tsutsui, Tetsuya| Kimata, Yoshihiro| Nakatsuka, Mikiya| Koshima, Isao| Saika, Takashi| Nasu, Yasutomo| Kumon, Hiromi| |
Abstract | <p>The first case of sex reassignment surgery (SRS) in our hospital was performed in January 2001; as of February, 2005, 4 cases of MTF-SRS had been performed. In the 2 most recent cases, we used penile and scrotal skin flaps to avoid complications. The depth and width of the new vagina was made to be adequate for sexual intercourse. Future attention should be focused on devising a surgical technique that will help prevent the complications of partial necrosis of the epidermal skin and wound dehiscence. Although ours is only an initial experience, we describe our surgical technique herein.</p> |
Keywords | gender identity disorder sex reassignment surgery male to female transsexual |
Amo Type | Article |
Published Date | 2005-10 |
Publication Title | Acta Medica Okayama |
Volume | volume59 |
Issue | issue5 |
Publisher | Okayama University Medical School |
Start Page | 231 |
End Page | 233 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | 英語 |
File Version | publisher |
Refereed | True |
PubMed ID | 16286961 |
Web of Science KeyUT | 000232835600008 |
JaLCDOI | 10.18926/AMO/32881 |
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FullText URL | fulltext.pdf |
Author | Murakami, Takanori| Ebara, Shin| Saika, Takashi| Irie, Shin| Takeda, Katsuji| Maki, Yoshio| Miyaji, Sadayuki| Manabe, Daisuke| Kaku, Haruki| Nasu, Yasutomo| Tsushima, Tomoyasu| Kumon, Hiromi| |
Abstract | <p>We evaluated the need for transurethral biopsy at first follow-up after intravesical bacillus Calmette-Guerin (BCG) therapy for superficial bladder cancer. The records of 84 patients with superficial bladder cancer who received a 6- or 8-week course of BCG were reviewed. Pathological results before BCG, cystoscopic findings, urinary cytology, and biopsy results for evaluation of BCG therapy were reviewed. All 19 patients with positive urinary cytology had evidence of positive bladder biopsy results. Fifty-three of 54 patients (98.1%) with no visible recurrent tumor and negative urinary cytology demonstrated negative pathological results on bladder biopsy. When not found in conjunction with positive urinary cytology, erythematous mucosa on cystoscopy was not an indicator of tumor recurrence or residual cancer. In conclusion, routine transurethral biopsy of the bladder for evaluating the response to BCG intravesical therapy is not necessary in patients who have no visible tumor on cystoscopy and negative urinary cytology./</p> |
Keywords | bladder cancer BCG therapy transurethral biopsy cystoscopy urinary cytology |
Amo Type | Original Article |
Published Date | 2007-12 |
Publication Title | Acta Medica Okayama |
Volume | volume61 |
Issue | issue6 |
Publisher | Okayama University Medical School |
Start Page | 341 |
End Page | 344 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | 英語 |
File Version | publisher |
Refereed | True |
PubMed ID | 18183079 |
JaLCDOI | 10.18926/AMO/57953 |
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FullText URL | 74_1_53.pdf |
Author | Kubota, Risa| Araki, Motoo| Wada, Koichiro| Kawamura, Kasumi| Maruyama, Yuki| Mitsui, Yosuke| Sadahira, Takuya| Ariyoshi, Yuichi| Iwata, Takehiro| Nishimura, Shingo| Takamoto, Atsushi| Sako, Tomoko| Edamura, Kohei| Kobayashi, Yasuyuki| Kano, Yuzuki| Kitagawa, Masashi| Tanabe, Katsuyuki| Sugiyama, Hitoshi| Wada, Jun| Watanabe, Masami| Watanabe, Toyohiko| Nasu, Yasutomo| |
Abstract | We investigated the feasibility of robotic renal autotransplantation (RAT) in a porcine model to reduce invasiveness of RAT. Five pigs underwent robotic RAT using the da Vinci® robotic system. A robotic left nephrectomy was performed in all cases. Robotic RAT was performed on the left side in all but one case. Four ports were used. In 3 cases, the kidney was taken out through the GelPort® and irrigated on ice with Ringer’s solution. In 2 cases, a complete intracorporeal robotic RAT was performed. An end-to-side anastomosis was performed between the renal vein and the external iliac vein and between the renal artery and the external iliac artery. Ureteroneocystostomy was also performed in 2 cases. All cases were performed robotically without open conversion. The median (IQR) console time was 3.1 (0.7) h, and the operative time was 3.8 (1.1) h. The estimated blood loss was 30 (0) ml. The warm ischemia time was 4.0 (0.2) min, and the cold ischemia time was 97 (17) min. Intracorporeal transarterial hypothermic renal perfusion was feasible in the 2 complete intracorporeal robotic RAT cases by using a perfusion catheter through a laparoscopic port. Robotic RAT has the potential to be a new minimally invasive substitute for conventional open surgery. |
Keywords | renal autotransplantation robotic porcine model transplantation |
Amo Type | Original Article |
Published Date | 2020-02 |
Publication Title | Acta Medica Okayama |
Volume | volume74 |
Issue | issue1 |
Publisher | Okayama University Medical School |
Start Page | 53 |
End Page | 58 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | 英語 |
Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 32099249 |
Web of Science KeyUT | 000516606200008 |
NAID | 120006795620 |