JaLCDOI 10.18926/AMO/55308
FullText URL 71_4_315.pdf
Author Fujii, Yosuke| Endo, Hirosuke| Mitani, Shigeru| Akazawa, Hirofumi| Tetsunaga, Tomonori| Miyake, Takamasa| Yamada, Kazuki| Aoki, Kiyoshi| Ozaki, Toshifumi|
Abstract We retrospectively reviewed 29 hips in which intertrochanteric osteotomies were performed for severe slipped capital femoral epiphyses. Mean age at surgery: 12.6 years. Mean follow-up period: 6 years. At the final follow-up evaluation, one patient had coxalgia, and six hips showed a limited range of motion. A pistol-grip deformity was observed in 13 hips, osteoarthritis in two hips, and a bump existed in 19 hips on the latest radiographs. Gradual remodeling of the bumps was observed post-operatively in 22 hips. The mean α and β angles and offset α and β improved over time. The remodeling proceeded rapidly for 1 year post-surgery. We compared hips classified as β angles of ≥ 63° to < 63° at the final follow-up evaluation, the mean β angle 1 year post-surgery, and the mean ratio of improvement of the β angle per year from 1 year post-surgery to the final follow up, which differed significantly. Nearly all of the patients who underwent intertrochanteric osteotomies had residual morphologic abnormalities, but few had clinical symptoms. The β angle 1 year post-surgery and the ratio of remodeling of the bump from 1 year post-surgery to the final follow-up can be regarded as a potential predictor of morphologic results after intertrochanteric osteotomy.
Keywords slipped capital femoral epiphyses intertrochanteric osteotomy residual femoral deformity femoroacetabular impingement bone remodeling
Amo Type Original Article
Published Date 2017-08
Publication Title Acta Medica Okayama
Volume volume71
Issue issue4
Publisher Okayama University Medical School
Start Page 315
End Page 323
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2017 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 28824187
Author Nishida, Keiichiro| Hashizume, Kenzo| Ozawa, Masatsugu| Takeshita, Ayumu| Kaneda, Daisuke| Nakahara, Ryuichi| Nasu, Yoshihisa| Shimamura, Yasunori| Inoue, Hajime| Ozaki, Toshifumi|
Published Date 2017-02
Publication Title Acta Medica Okayama
Volume volume71
Issue issue1
Content Type Journal Article
JaLCDOI 10.18926/AMO/54824
Author Furumatsu, Takayuki| Shukunami, Chisa| Amemiya-Kudo, Michiyo| Shimano, Hitoshi| Ozaki, Toshifumi|
Published Date 2010-01
Publication Title The International Journal of Biochemistry & Cell Biology
Volume volume42
Issue issue1
Content Type Journal Article
JaLCDOI 10.18926/AMO/54980
FullText URL 71_2_119.pdf
Author Oda, Yoshiaki| Takigawa, Tomoyuki| Sugimoto, Yoshihisa| Tanaka, Masato| Akazawa, Hirofumi| Ozaki, Toshifumi|
Abstract Patients with cerebral palsy (CP) frequently present with scoliosis; however, the pattern of curve progression is difficult to predict. We aimed to clarify the natural course of the progression of scoliosis and to identify scoliosis predictors. This was a retrospective, single-center, observational study. Total of 92 CP patients from Asahikawasou Ryouiku Iryou Center in Okayama, Japan were retrospectively analyzed. Cobb angle, presence of hip dislocation and pelvic obliquity, and Gross Motor Function Classification System (GMFCS) were investigated. Severe CP was defined as GMFCS level IV or V. The mean observation period was 10.7 years. Thirtyfour severe CP patients presented with scoliosis and were divided into 3 groups based on their clinical courses: severe, moderate and mild. The mean Cobb angles at the final follow-up were 129°, 53°, and 13° in the severe, moderate, and mild groups, respectively. The average progressions from 18 to 25 years were 2.7°/year, 0.7°/year, and 0.1°/year in the severe, moderate, and mild curve groups, respectively. We observed the natural course of scoliosis and identified 3 courses based on the Cobb angle at 15 and 18 years of age. This method of classification may help clinicians predict the patients’ disease progression.
Keywords severe cerebral palsy scoliosis natural course Cobb angle progression
Amo Type Original Article
Published Date 2017-04
Publication Title Acta Medica Okayama
Volume volume71
Issue issue2
Publisher Okayama University Medical School
Start Page 119
End Page 126
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2017 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 28420893
JaLCDOI 10.18926/AMO/31575
FullText URL fulltext.pdf
Author Ozaki, Toshifumi| Sugihara, Shinsuke| Inoue, Hajime|
Abstract <p>We report second malignant neoplasms which developed between 7 and 19 years after treatment in 3 pediatric patients with osteosarcoma. Two patients had been treated with only surgery, and another patient had been treated with a combination of surgery with chemotherapy and radiation therapy for primary lesions. Pediatric patients with osteosarcoma, in particular, require careful long-term follow-up to monitor not only metastases but also development of second malignant neoplasms.</p>
Keywords osteosarcoma second malignancy
Amo Type Article
Published Date 1993-04
Publication Title Acta Medica Okayama
Volume volume47
Issue issue2
Publisher Okayama University Medical School
Start Page 129
End Page 133
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 8506750
Web of Science KeyUT A1993LA45200010
JaLCDOI 10.18926/AMO/48692
FullText URL 66_4_363.pdf
Author Tanaka, Masato| Sugimoto, Yoshihiro| Misawa, Haruo| Takigawa, Tomoyuki| Kunisada, Toshiyuki| Ozaki, Toshifumi|
Abstract Spinal deformity is an important clinical manifestation after surgery for spinal cord tumors. One-third of patients who receive laminectomies and irradiation of the spinal column develop scoliosis, kyphosis, or kyphoscoliosis. Recent reports indicate good results after scoliosis surgery using segmental pedicle screws and a navigation system, but these reported studies have not included surgery for post-laminectomy kyphosis. Hooks and wires are ineffective in such patients who undergo laminectomy, and there are also high perioperative risks with insertion of pedicle screws because landmarks have been lost. Here, we report on the 5-year follow-up of a 13-year-old male patient with post-laminectomy and post-irradiation thoracic kyphoscoliosis after surgical treatment of spinal astrocytoma. Posterior segmental pedicle screw fixation was performed safely using a computer-assisted technique. The authors present the first case report for treatment of this condition using a navigation system.
Keywords astrocytoma scoliosis kyphoscoliosis navigation segmental pedicle screw fixation
Amo Type Case Report
Published Date 2012-08
Publication Title Acta Medica Okayama
Volume volume66
Issue issue4
Publisher Okayama University Medical School
Start Page 363
End Page 368
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2012 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 22918210
Web of Science KeyUT 000307918900010
FullText URL fulltext.pdf
Author Tetsunaga, Tomoko| Tetsunaga, Tomonori| Nishida, Keiichiro| Misawa, Haruo| Takigawa, Tomoyuki| Yamane, Kentaro| Tsuji, Hironori| Takei, Yoshitaka| Ozaki, Toshifumi|
Keywords Peripheral neuropathic pain Mirogabalin Pregabalin Adverse event
Published Date 2020-05-26
Publication Title Journal of Orthopaedic Surgery and Research
Volume volume15
Issue issue1
Publisher Springer
Start Page 191
ISSN 1749-799X
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version publisher
PubMed ID 32456647
DOI 10.1186/s13018-020-01709-3
Web of Science KeyUT 000538017400002
Related Url isVersionOf https://doi.org/10.1186/s13018-020-01709-3
JaLCDOI 10.18926/AMO/54811
FullText URL 70_6_477.pdf
Author Nishida, Keiichiro| Machida, Takahiro| Horita, Masahiro| Hashizume, Kenzo| Nakahara, Ryuichi| Nasu, Yoshihisa| Ohashi, Hideki| Saiga, Kenta| Ozaki, Toshifumi|
Abstract The metatarsophalangeal (MTP) joints are often and predominantly affected in rheumatoid arthritis. The aim of the current study was to describe surgical techniques of shortening oblique osteotomy for lesser metatarsal bone with screw fixation at the osteotomy site, and to investigate the short-term clinical outcomes of our procedure. Twenty-seven feet (78 toes) of 24 RA patients underwent the shortening oblique osteotomy for the correction of deformity at the lesser MTP joints. The average Japanese Society of Surgery of the Foot (JSSF) standard rating system for the RA foot and ankle scale improved significantly from 59.6 points preoperatively to 88.3 points postoperatively (p<0.001). Twenty-four feet (89 ) were free from metatarsalgia and symptomatic callosities at the lesser MTP joint after surgery. Our present findings showed satisfactory early clinical outcomes of the shortening oblique osteotomy of the metatarsal bone with screw fixation for RA forefoot.
Keywords shortening oblique osteotomy rheumatoid arthritis forefoot screw fixation
Amo Type Original Article
Published Date 2016-12
Publication Title Acta Medica Okayama
Volume volume70
Issue issue6
Publisher Okayama University Medical School
Start Page 477
End Page 483
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 28003673
Author Ito, Tatsuo| Ouchida, Mamoru| Morimoto, Yuki| Yoshida, Aki| Jitsumori, Yoshimi| Ozaki, Toshifumi| Sonobe, Hiroshi| Inoue, Hajime| Shimizu, Kenji|
Published Date 2005-06-28
Publication Title Cancer Letters
Volume volume224
Issue issue2
Content Type Journal Article
Author Furumatsu, Takayuki| Ozaki, Toshifumi| Asahara, Hiroshi|
Published Date 2009-05
Publication Title The International Journal of Biochemistry & Cell Biology
Volume volume41
Issue issue5
Content Type Journal Article
JaLCDOI 10.18926/AMO/52901
FullText URL 68_5_313.pdf
Author Yamane, Kentaro| Tanaka, Masato| Sugimoto, Yoshihisa| Ichimura, Kouichi| Ozaki, Toshifumi|
Abstract Ossified meningioma is classified histologically as a phenotype of metaplastic meningioma, and it is extremely rare. There are only 12 cases involving ossified spinal meningiomas in the literature. We present the case of a 61-year-old female with a primary tumor within the ventral spinal canal at T12. Although we performed a total tumor excision using an ultrasonic bone aspirator, a temporary deterioration of motor evoked potentials (MEPs) was observed during curettage with a Kerrison rongeur. The neurologic findings worsened immediately after surgery. Histologically, the tumor was diagnosed as a metaplastic meningioma with osseous differentiation. In order to avoid spinal cord injury, great care must be taken when removing an ossified meningioma located on the ventral spinal cord.
Keywords spinal metaplastic meningioma osseous differentiation ossified meningioma ultrasonic bone aspirator post-operative course
Amo Type Case Report
Published Date 2014-10
Publication Title Acta Medica Okayama
Volume volume68
Issue issue5
Publisher Okayama University Medical School
Start Page 313
End Page 316
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2014 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 25338489
Web of Science KeyUT 000343269300009
JaLCDOI 10.18926/AMO/48560
FullText URL 66_3_213.pdf
Author Kataoka, Masaki| Kunisada, Toshiyuki| Tanaka, Masato| Takeda, Ken| Itani, Satoru| Sugimoto, Yoshihisa| Misawa, Haruo| Senda, Masuo| Nakahara, Shinnosuke| Ozaki, Toshifumi|
Abstract There are a variety of treatment options for patients with spinal metastasis, and predicting prognosis is essential for selecting the proper treatment. The purpose of the present study was to identify the significant prognostic factors for the survival of patients with spinal metastasis. We retrospectively reviewed 143 patients with spinal metastasis. The median age was 61 years. Eleven factors reported previously were analyzed using the Cox proportional hazards model:gender, age, performance status, neurological deficits, pain, type of primary tumor, metastasis to major organs, previous chemotherapy, disease-free interval before spinal metastasis, multiple spinal metastases, and extra-spinal bone metastasis. The average survival of study patients after the first visit to our clinic was 22 months. Multivariate survival analysis demonstrated that type of primary tumor (hazard ratio [HR]=6.80, p<0.001), metastasis to major organs (HR=2.01, p=0.005), disease-free interval before spinal metastasis (HR=1.77, p=0.028), and extra-spinal bone metastasis (HR=1.75, p=0.017) were significant prognostic factors. Type of primary tumor was the most powerful prognostic factor. Other prognostic factors may differ among the types of primary tumor and may also be closely associated with primary disease activity. Further analysis of factors predicting prognosis should be conducted with respect to each type of primary tumor to help accurately predict prognosis.
Keywords spine metastasis survival prognostic factor cancer
Amo Type Original Article
Published Date 2012-06
Publication Title Acta Medica Okayama
Volume volume66
Issue issue3
Publisher Okayama University Medical School
Start Page 213
End Page 219
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2012 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 22729101
Web of Science KeyUT 000305669700004
Author Hiranaka, Takaaki| Furumatsu, Takayuki| Okazaki, Yuki| Yamawaki, Tadashi| Okazaki, Yoshiki| Kodama, Yuya| Kamatsuki, Yusuke| Ozaki, Toshifumi|
Keywords Medial meniscus Posterior root tear Bilateral injury Predictor Medial tibial slope Sensitivity and specificity
Note This is a post-peer-review, pre-copyedit version of an article published in Knee Surgery, Sports Traumatology, Arthroscopy. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00167-020-06079-1. </br>This fulltext is available in June 2021.|
Published Date 2020-06-01
Publication Title Knee Surgery, Sports Traumatology, Arthroscopy
Publisher Springer
ISSN 0942-2056
NCID AA10973641
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version Author
PubMed ID 32488369
DOI 10.1007/s00167-020-06079-1
Web of Science KeyUT 000538465000003
Related Url isVersionOf https://doi.org/10.1007/s00167-020-06079-1
JaLCDOI 10.18926/AMO/49047
FullText URL 66_6_499.pdf
Author Sugimoto, Yoshihisa| Tanaka, Masato| Nakahara, Ryuichi| Misawa, Haruo| Kunisada, Toshiyuki| Ozaki, Toshifumi|
Abstract An 11 year-old girl had 66 degrees of kyphosis in the thoracolumbar junction. For the purpose of planning for kyphosis correction, we created a 3-D, full-scale model of the spine and consulted spinal navigation. Three-dimensional models are generally used as tactile guides to verify the surgical approach and portray the anatomic relations specific to a given patient. We performed posterior fusion from Th10 to L3, and vertebral column resection of Th12 and L1. Screw entry points, directions, lengths and diameters were determined by reference to navigation. Both tools were useful in the bone resection. We could easily detect the posterior element to be resected using the 3D model. During the anterior bony resection, navigation helped us to check the disc level and anterior wall of the vertebrae, which were otherwise difficult to detect due to their depth in the surgical field. Thus, the combination of navigation and 3D models helped us to safely perform surgery for a patient with complex spinal deformity.
Keywords congenital scoliosis kyphosis navigation 3-dimensional models
Amo Type Case Report
Published Date 2012-12
Publication Title Acta Medica Okayama
Volume volume66
Issue issue6
Publisher Okayama University Medical School
Start Page 499
End Page 502
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2012 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 23254585
Web of Science KeyUT 000312966100010
JaLCDOI 10.18926/AMO/30758
FullText URL fulltext.pdf
Author Tanaka, Masato| Nakahara, Shinnosuke| Ito, Yauo| Nakanishi, Kazuo| Sugimoto, Yoshihisa| Ikuma, Hisanori| Ozaki, Toshifumi|
Abstract <p>The purpose of this study was to investigate the surgical outcomes and to determine indicators of the necessity of surgical intervention. Twelve consecutive patients harboring symptomatic sacral perineural cysts were treated between 1995 and 2003. All patients were assessed for neurological deficits and pain by neurological examination. Magnetic resonance of imaging, computerized tomography, and myelography were performed to detect signs of delayed filling of the cysts. We performed a release of the valve and imbrication of the sacral cysts with laminectomies in 8 cases or recapping laminectomies in 4 cases. After surgery, symptoms improved in 10 (83%) of 12 patients, with an average follow-up of 27 months. Ten patients had sacral perineural cysts with signs of positive filling defect. Two (17%) of 12 patients experienced no significant improvement. In one of these patients, the filling defect was negative. In conclusion, a positive filling defect may become an indicator of good treatment outcomes.</p>
Keywords Tarlov cyst sacral perineural cyst meningeal cyst meningeal diverticulum sacral radiculopathy
Amo Type Article
Published Date 2006-02
Publication Title Acta Medica Okayama
Volume volume60
Issue issue1
Publisher Okayama University Medical School
Start Page 65
End Page 70
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 16508691
Web of Science KeyUT 000235538900008
JaLCDOI 10.18926/AMO/31849
FullText URL fulltext.pdf
Author Tanaka, Masato| Nakahara, Shinnosuke| Ito, Yasuo| Kunisada, Toshiyuki| Misawa, Haruo| Koshimune, Koichiro| Ozaki, Toshifumi|
Abstract <p>Surgical treatment of metastatic spinal cord compression is controversial. The purpose of this study was to investigate the effectiveness of our current surgical treatments and the use of spinal instrumentation. In this retrospective study covering the years between 1990 and 2006, 100 patients with spinal metastases which were secondary to various cancers underwent posterior and/or anterior decompression with spinal stabilization for the purposes of reduction of pain, and/or to help correct or improve neurological deficits. The group was made up of 60 men and 40 women whose ages ranged from 16 to 83 years (average of 60 years), and the average follow-up period was 14 months. The effect of treatment upon pain relief and neural deficits was assessed, and the cumulative survival rate was calculated by the Kaplan-Meier method. The average surgical time was 185min. This was calculated based on the following times, listed here with the surgery type:178min for posterior surgery;245min for anterior surgery;465 min for combined surgery;and 475min for total en bloc spondylectomy. Average blood loss during surgery was 1,630 ml for posterior surgery, 1,760 ml for anterior surgery, 1,930 ml for combined surgery, and 3,640 ml for total en bloc spondylectomy. Preoperative pain and paralysis were improved by 88% and 53%, respectively. In regards to surgical complications, postoperative epidural hematoma was observed in 2 patients, and instrumentation-related infection was observed in 1. Only 2 patients died within 2 months of surgery. In conclusion, posterior and/or anterior decompression with spinal stabilization is a safe and effective treatment for patients with spinal metastases, and can improve their quality of life.</p>
Keywords spinal metastasis spinal surgery instrumentation
Amo Type Original Article
Published Date 2009-06
Publication Title Acta Medica Okayama
Volume volume63
Issue issue3
Publisher Okayama University Medical School
Start Page 145
End Page 150
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 19571901
Web of Science KeyUT 000267388200004
Author Furumatsu, Takayuki| Ozaki, Toshifumi| Asahara, Hiroshi|
Published Date 2010-08-02
Publication Title 岡山医学会雑誌
Volume volume122
Issue issue2
Content Type Journal Article
Author Mochizuki, Yusuke| Tazawa, Hiroshi| Demiya, Koji| Kure, Miho| Kondo, Hiroya| Komatsubara, Tadashi| Sugiu, Kazuhisa| Hasei, Joe| Yoshida, Aki| Kunisada, Toshiyuki| Urata, Yasuo| Kagawa, Shunsuke| Ozaki, Toshifumi| Fujiwara, Toshiyoshi|
Keywords Oncolytic adenovirus hTERT Immunogenic cell death ATP CD8
Note This is a post-peer-review, pre-copyedit version of an article published in Cancer Immunology, Immunotherapy. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00262-020-02774-7. </br>This fulltext is available in Nov. 2021.|
Published Date 2020-11-05
Publication Title Cancer Immunology, Immunotherapy
Publisher Springer
Start Page 0340-7004
NCID AA00598499
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version author
PubMed ID 33151368
DOI 10.1007/s00262-020-02774-7
Web of Science KeyUT 000586350500002
Related Url isVersionOf https://doi.org/10.1007/s00262-020-02774-7
FullText URL CORR477_8_1892.pdf
Author Kunisada, Toshiyuki| Fujiwara, Tomohiro| Hasei, Joe| Nakata, Eiji| Senda, Masuo| Ozaki, Toshifumi|
Published Date 2019-08
Publication Title Clinical Orthopaedics and Related Research
Volume volume477
Issue issue8
Publisher Lippincott, Williams & Wilkins
Start Page 1892
End Page 1901
ISSN 0009-921X
NCID AA00607942
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version author
PubMed ID 30985613
DOI 10.1097/CORR.0000000000000764
Web of Science KeyUT 000509664400024
Related Url isVersionOf https://doi.org/10.1097/CORR.0000000000000764
JaLCDOI 10.18926/AMO/57947
FullText URL 74_1_7.pdf
Author Sanki, Tomoaki| Endo, Hirosuke| Tetsunaga, Tomonori| Furumatsu, Takayuki| Yamada, Kazuki| Ozaki, Toshifumi|
Abstract We investigated the relationship between the initial contact status and stress shielding in total hip arthroplasty (THA) using fit-and-fill type straight-stem implants. In addition we evaluated the clinical and radiographic outcomes. Subjects were 100 hips of 94 patients who underwent THA and were followed-up for ≥10 years. Contact areas with the femoral cortical bone were investigated according to the zonal distribution of Gruen using postoperative CT images. Depending on the number of contact areas, the patients were classified into high contact [HC], medium contact [MC], and low contact [LC] groups. Radiographic and clinical outcomes were evaluated. In the HC group (20 hips), severe stress shielding was observed in 12 hips, which was statistically significant (p=0.008). In the LC group (29 hips), mild stress shielding was observed in 27 hips which was statistically significant (p<0.001). No significant differences were observed among the 3 groups in clinical outcomes, Harris hip score (p=0.719) or Japanese Orthopedic Association (JOA) score (p=0.301). In insertion of cementless collared fit-and-fill type straight-stem implants, severe late stress shielding of the femoral bone may occur if high contact of the femoral component is achieved. However, the degree of stress shielding does not result in adverse clinical outcomes.
Keywords fit-and-fill stress shielding cementless straight stem total hip arthroplasty
Amo Type Original Article
Published Date 2020-02
Publication Title Acta Medica Okayama
Volume volume74
Issue issue1
Publisher Okayama University Medical School
Start Page 7
End Page 15
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32099243
Web of Science KeyUT 000516606200002
NAID 120006795614