| JaLCDOI | 10.18926/AMO/30749 |
|---|---|
| FullText URL | fulltext.pdf |
| Author | Komiyama, Takamitsu| Nishida, Keiichiro| Yorimitsu, Masanori| Doi, Hideyuki| Miyazawa, Shinichi| Kitamura, Ai| Yoshida, Aki| Nasu, Yoshihisa| Abe, Nobuhiro| Ozaki, Toshifumi| |
| Abstract | Ossification disturbance in femoral head reportedly is seen in the Spontaneously Hypertensive rats (SHR) between ages of 10 and 20 weeks. We investigated serum and tissue levels of insulin-like growth factor-1 (IGF-1) and vascular endothelial growth factor (VEGF) in SHR relevant to the ossification disturbance and osteonecrosis of the femoral head. Serum levels of IGF-1 and VEGF were significantly lower in SHR than in Wistar Kyoto rats (WKY) at weeks 5, 10, 15 and 20 (p<0.005). The incidence of histological ossification disturbance of the femoral head was higher in SHR (59%) than in WKY (40%) at week 20. Lower serum and local levels of VEGF in SHR appeared to be related to the incomplete ossification of the femoral heads. Immunohistochemical study showed significantly lower numbers of IGF-1 and VEGF positive chondrocytes in the femoral epiphyseal cartilage of SHR than in those of WKY at weeks 10, 15 and 20. Our results suggest that local and/or systemic levels of IGF-1 and VEGF between ages of 5 and 20 weeks might play roles in the pathogenesis of ossifi cation disturbance of the femoral head in SHR. |
| Keywords | spontaneous hypertensive rats insulin like growth factor-1 vascular endothelial growth factor ossification disturbance osteonecrosis |
| Amo Type | Article |
| Published Date | 2006-06 |
| Publication Title | Acta Medica Okayama |
| Volume | volume60 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 141 |
| End Page | 148 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | 英語 |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 16838042 |
| Web of Science KeyUT | 000238503600001 |
| JaLCDOI | 10.18926/AMO/30739 |
|---|---|
| FullText URL | fulltext.pdf |
| Author | Aiga, Ayako| Asaumi, Koji| Lee, You Jin| Kadota, Hiroaki| Mitani, Shigeru| Ozaki, Toshifumi| Takigawa, Masaharu| |
| Abstract | The localization and expression of neurotrophins and their receptors during distraction osteogenesis was investigated in 72 male rat femurs (11 weeks old) to further clarify the concurrence of cellular and molecular events of new bone formation. After osteotomy, a 7-day lag phase was followed by distraction at the rate of 0.25 mm/12 h for 21 days (distraction phase), and a 7-day consolidation phase. The localization of neurotrophins (NGF, BDNF and NT-3) and their receptors tropomyosinrelated kinases (TRKA, TRKB and TRKC) by immunostaining showed positive staining in bone forming cells in each stage, although the presence and staining intensity varied by cell type and phase. The expressions of NGF, BDNF and NT-3 by real-time polymerase chain reaction (real-time PCR) showed that the peak of the mRNA expression of NGF occurred 10 days after distraction. NT-3 increased during bone extension, but decreased when distraction stopped. In contrast, BDNF continued to increase gradually throughout the distraction and consolidation phases. These findings suggest that neurotrophins and their receptors may play different roles in endochondral and intramembranous ossification in distraction osteogenesis. The tension stress caused by distraction may stimulate the expression of neurotrophins and their receptors, and promote osteogenesis. |
| Keywords | neurotrophin Trk distraction osteogenesis mechanical stress |
| Amo Type | Article |
| Published Date | 2006-10 |
| Publication Title | Acta Medica Okayama |
| Volume | volume60 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 267 |
| End Page | 277 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | 英語 |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 17072373 |
| Web of Science KeyUT | 000241509000003 |
| JaLCDOI | 10.18926/AMO/30721 |
|---|---|
| FullText URL | fulltext.pdf |
| Author | Inoue, Atsushi| Asaumi, Koji| Endo, Hirosuke| Fujiwara, Kazuo| Mitani, Shigeru| Ozaki, Toshifumi| |
| Abstract | The present retrospective study assessed radiographs to determine socket wear in total hip arthroplasty (THA) with 22-mm zirconia or COP (Cobalt-Chrome alloy rich in Cobalt and Phosphorous) heads, and in cemented stems at more than 10 years after operation. Sockets of ultra high molecular weight polyethylene were used in each of two THA groups (13 hips each) in a clinical trial in our hospital between 1989 and 1990. Three observers carried out masked assessments of the radiographs. Upon fi nal examination, there was no remarkable loosening in the zirconia or COP group, and no case had required revision surgery as of 2005. There was a statistically signifi cant diff erence between the 2 groups in average annual linear wear, at 0.093 mm/year and 0.046 mm/year in the zirconia and COP groups, respectively. Volume wear and average annual volume wear were also signifi cantly greater in the zirconia group despite its superior mechanical strength and toughness in vitro. Our present fi ndings do not confi rm early expectations of lower wear in long-term results of 22-mm zirconia femoral heads used in THA. |
| Keywords | total hip arthroplasty zirconia head COP head polyethylene wear |
| Amo Type | Original Article |
| Published Date | 2006-12 |
| Publication Title | Acta Medica Okayama |
| Volume | volume60 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 311 |
| End Page | 318 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | 英語 |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 17189974 |
| Web of Science KeyUT | 000243019000002 |
| Author | Tanaka, Masato| Sugimoto, Yoshihisa| Misawa, Haruo| Takahata, Tomohiro| Ozaki, Toshifumi| |
|---|---|
| Published Date | 2010-04-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume122 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Mimura, Hidefumi| Fujiwara, Hiroyasu| Hiraki, Takao| Gobara, Hideo| Shibamoto, Kentaro| Kimata, Yoshihiro| Ozaki, Toshifumi| Sasaki, Satoru| Kanazawa, Susumu| |
|---|---|
| Published Date | 2010-04-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume122 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | 尾﨑 敏文| |
|---|---|
| Published Date | 2006-01-04 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume117 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Kunisada, Toshiyuki| Ozaki, Toshifumi| |
|---|---|
| Published Date | 2008-05-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume120 |
| Issue | issue1 |
| Content Type | Journal Article |
| FullText URL | K000901.pdf |
|---|---|
| Author | Ozaki, Toshifumi| |
| Published Date | 1991-03-28 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第901号 |
| Granted Date | 1991-03-28 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | 日本語 |
