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ID 46919
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Author
Kurami, Shunsuke
Sisido, Masahiko
Abstract
To investigate the antisense effect of a pyrrolidine-based oxy-peptide nucleic acid (POPNA), we carried out the LacZ reporter assay using a 12-mer trans-l-POPNA conjugated with a cell-penetrating peptide (antisense reagent). The antisense effect of the conjugated POPNA (inhibition of LacZ activity) was comparable to that shown by a Nielsen-type peptide nucleic acid. Furthermore, the conjugated POPNA could switch the LacZ activity over a wide range of ambient temperatures.
Keywords
Peptide nucleic acid
Cell-penetrating peptide
Antisense effect
Published Date
2011-01
Publication Title
Bioorganic & Medicinal Chemistry Letters
Volume
volume21
Issue
issue1
Publisher
Pergamon-Elsevier Science Ltd,
Start Page
225
End Page
227
ISSN
0960-894X
NCID
AA1079577X
Content Type
Journal Article
language
英語
Copyright Holders
© 2010 Elsevier Ltd. All rights reserved.
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author
Refereed
True
DOI
PubMed ID
Web of Sience KeyUT