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ID 46941
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Author
Takahashi, Akiko
Sisido, Masahiko
Abstract
We synthesized 16 pyrrolidine-based oxy-peptide nucleic acid (POPNA) monomers carrying four different nucleobases onto four different stereoisomers of pyrrolidine rings. Using these monomers, we prepared POPNA oligomers, which formed sequence-specific hybrids with DNAs. The oligomer configurations influenced the hybrid stability. The oligomers were not taken into CHO cells. However, they could enter the cell cytoplasm when mixed with the influenza virus hemagglutinin peptide-arginine heptamer conjugate.
Keywords
Peptide nucleic acid
Solid-phase peptide synthesis
Cell-penetrating peptide
Confocal laser scanning microscopy
Published Date
2010-12-18
Publication Title
Tetrahedron
Volume
volume66
Issue
issue51
Publisher
Pergamon-Elsevier Science Ltd.
Start Page
9659
End Page
9666
ISSN
0040-4020
NCID
AA00861787
Content Type
Journal Article
language
英語
Copyright Holders
© 2010 Elsevier Ltd. All rights reserved.
File Version
author
Refereed
True
DOI
Web of Sience KeyUT