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ID 60285
Author
Sugimoto, Seiichiro Department of General Thoracic Surgery, Okayama University Hospital ORCID Kaken ID publons researchmap
Soh, Junichi Department of General Thoracic Surgery, Okayama University Hospital
Suzawa, Ken Department of General Thoracic Surgery, Okayama University Hospital
Miyoshi, Kentaroh Department of General Thoracic Surgery, Okayama University Hospital Kaken ID
Otani, Shinji Department of General Thoracic Surgery, Okayama University Hospital
Yamamoto, Hiromasa Department of General Thoracic Surgery, Okayama University Hospital ORCID Kaken ID publons researchmap
Okazaki, Mikio Department of General Thoracic Surgery, Okayama University Hospital
Yamane, Masaomi Department of General Thoracic Surgery, Okayama University Hospital Kaken ID researchmap
Oto, Takahiro Department of General Thoracic Surgery, Okayama University Hospital Kaken ID publons
Kanazawa, Susumu Department of Radiology, Okayama University Hospital Kaken ID publons
Kiura, Katsuyuki Department of Respiratory Medicine, Okayama University Hospital ORCID Kaken ID publons researchmap
Toyooka, Shinichi Department of General Thoracic Surgery, Okayama University Hospital ORCID Kaken ID publons researchmap
Abstract
Purpose
Some long-term survivors after surgery for locally advanced non-small cell lung cancer (NSCLC) treated with induction chemoradiotherapy (trimodality treatment) develop chronic pulmonary aspergillosis (CPA). The aim of our study was to assess the characteristics and outcomes of CPA that develops after trimodality treatment. Methods
We retrospectively reviewed the data of 187 NSCLC patients who underwent trimodality treatment between 1999 and 2018.
Results
Six male ever-smoker patients developed CPA. All 6 patients had undergone extended resection for NSCLC and had a history of either adjuvant chemotherapy (n = 3) or radiation pneumonitis (n = 4). Among the 4 patients with CPA localized in a single lung, 3 patients were treated surgically (completion pneumonectomy or cavernostomy) and 1 patient was treated with antifungal therapy alone. Both treatments led to the improved control of CPA. In contrast, patients with CPA in both lungs were not candidates for surgery, and died of CPA. The survival rates after trimodality treatment in the CPA group and the group without CPA were comparable (10-year survival rate, 50.0% vs. 57.6%, P = 0.59).
Conclusion
The early diagnosis of CPA localized in a single lung after NSCLC surgery is critical to improving control and survival in patients with CPA.
Keywords
Lung cancer
Aspergillosis
Surgery
Radiation
Chemotherapy
Note
This is a post-peer-review, pre-copyedit version of an article published in Surgery Today. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00595-020-01960-5.
This fulltext is available on Jun. 2021.
Published Date
2020-01-21
Publication Title
Surgery Today
Volume
volume50
Issue
issue8
Publisher
Springer
Start Page
863
End Page
871
ISSN
0941-1291
NCID
AA10824685
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
File Version
author
PubMed ID
DOI
Web of Science KeyUT
Related Url
isVersionOf https://doi.org/10.1007/s00595-020-01960-5