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ID 48895
FullText URL
Author
Nogami, Tomohiro
Shien, Tadahiko ORCID Kaken ID publons
Tanaka, Takehiro Kaken ID
Nishiyama, Keiko
Mizoo, Taeko
Iwamto, Takayuki
Ikeda, Hirokuni
Taira, Naruto Kaken ID
Doihara, Hiroyoshi Kaken ID researchmap
Miyoshi, Shinichiro Kaken ID publons researchmap
Abstract
Background Recently, evidence in support of the cancer stem cell (CSC) hypothesis has been accumulating. On the other hand, it has been reported that the expression of aldehyde dehydrogenase 1 (ALDH1) in primary breast cancer is a powerful predictor of a poor clinical outcome, and that breast cancer stem cells express ALDH1. According to the CSC hypothesis, development of metastases requires the dissemination of CSC that may remain dormant and be reactivated to cause tumor recurrence. In this study, we investigated whether the detection of CSC in axillary lymph node metastases (ALNM) might be a significant prognostic factor in patients with breast cancer. Methods From 1998 to 2006, 40 primary breast cancer patients with ALNM, the number of metastatic nodes varying in number from 1 to 3, underwent surgery at Okayama University; of these, 15 patients developed tumor recurrence. We retrospectively evaluated the common clinicopathological features and the expression of ER, HER2, ALDH1, and Ki67 in both the primary lesions and the ALNM, and analyzed the correlations between the expression of these biological markers and the disease-free survival (DFS). Results Expression of ALDH1 in the ALNM was significantly associated with the DFS (P = 0.037). Conclusion Evaluation of biomarker expression in ALNM could be useful for prognosis in breast cancer patients with 1–3 metastatic lymph nodes.
Keywords
Cancer stem cell
ALDH1
Axillary lymph node metastases
IHC
Published Date
2012-03-10
Publication Title
Breast Cancer
Publisher
Springer Japan
ISSN
1880-4233
Content Type
Journal Article
Official Url
http://www.springerlink.com/content/76375p0214281kw5/
Related Url
http://ousar.lib.okayama-u.ac.jp/metadata/48889
language
英語
Copyright Holders
© The Japanese Breast Cancer Society 2012
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True
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