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ID 53952
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Author
Katayama, Akihiro
Kanzaki, Motoko
Nunoue, Tomokazu
Hida, Kazuyuki
Wada, Nozomu
Yasunaka, Tetsuya
Takaki, Akinobu Kakenhi
Yamamoto, Kazuhide
Kiyonari, Hiroshi
Abstract
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. Gpnmb is classified as a type 1 membrane protein and its soluble form is secreted by ADAM10-mediated cleavage. Gpnmb mRNA was found in the Kupffer cells and white adipose tissues (WATs) and its upregulation in obesity was recently found. Here, we generated aP2 promoter-driven Gpnmb transgenic (Tg) mice and the overexpression of Gpnmb ameliorated the fat accumulation and fibrosis of the liver in diet-induced obesity model. Soluble form of Gpnmb in sera was elevated in Gpnmb Tg mice and Gpnmb concentrated in hepatic macrophages and stellate cells interacted with calnexin, which resulted in the reduction of oxidative stress. In the patients with non-alcoholic steatohepatitis, serum soluble GPNMB concentrations were higher compared with the patients with simple steatosis. The GPNMB is a promising biomarker and therapeutic target for the development and progression of NAFLD in obesity.
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Published Date
2015
Publication Title
Scientific reports
Volume
volume5
Publisher
Nature Publishing Group
Start Page
16920
ISSN
2045-2322
Content Type
Journal Article
Official Url
http://dx.doi.org/10.1038/srep16920
Related Url
http://ousar.lib.okayama-u.ac.jp/metadata/53951
language
英語
Copyright Holders
© 2015 Nature Publishing Group
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True
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