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ID 49253
JaLCDOI
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Thumnail 67_1_19.pdf 5.17 MB
Author
Furukawa, Masashi
Shien, Kazuhiko
Maki, Yuho
Muraoka, Takayuki
Tanaka, Norimitsu
Ueno, Tsuyoshi
Toyooka, Shinichi Kakenhi
Abstract
Nuclear factor of κ-light polypeptide gene enhancer in B cells inhibitor α (NFKBIA), which is a tumor suppressor gene, was found to be silenced in lung adenocarcinomas. We examined NFKBIA expression, mutations in the EGFR and K-ras genes, and EML4-ALK fusion in 101 resected lung adenocarcinoma samples from never-smokers. NFKBIA expression was evaluated using immunohistochemistry. NFKBIA expression was negative in 16 of the 101 samples (15.8%). EGFR and K-ras mutations and EML4-ALK fusion were detected in 61 (60.5%), 1 (1.0%), and 2 (2.0%) of the 101 samples, respectively, in a completely mutually exclusive manner. Negative NFKBIA expression was observed significantly more frequently among the tumors with none of the three genetic alterations compared to those with such alterations (p=0.009). In addition, negative NFKBIA expression was significantly more frequent among the EGFR-wild type samples compared to the EGFR-mutant samples (p=0.013). In conclusion, NFKBIA expression was silenced in adenocarcinomas without EGFR/K-ras mutations or EML4-ALK fusion, suggesting that the silencing of NFKBIA may play an important role in the carcinogenesis of adenocarcinomas independent of EGFR/K-ras mutations or EML4-ALK fusion.
Keywords
never-smoker
lung cancer
adenocarcinoma
nuclear factor of κ-light polypeptide gene enhancer in B cells inhibitor α
epidermal growth factor receptor
Amo Type
Original Article
Published Date
2013-02
Publication Title
Acta Medica Okayama
Volume
volume67
Issue
issue1
Publisher
Okayama University Medical School
Start Page
19
End Page
24
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
Copyright Holders
CopyrightⒸ 2013 by Okayama University Medical School
File Version
publisher
Refereed
True
PubMed ID
Web of Sience KeyUT
Related Url
http://ousar.lib.okayama-u.ac.jp/metadata/52534