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ID 52036
FullText URL
Author
Maki, Yuho
Ichimura, Kouichi
Furukawa, Masashi
Muraoka, Takayuki
Tanaka, Norimitsu
Ueno, Tsuyoshi
Yamamoto, Hiromasa ORCID Kaken ID researchmap
Asano, Hiroaki Kaken ID
Toyooka, Shinichi
Miyoshi, Shinichiro Kaken ID publons researchmap
Abstract
High expression levels of glucose transporter isoform 1 (GLUT1) and Ki-67 are reportedly associated with malignancy-related clinicopathological factors in malignant tumors. Recently, a new histological IASLC/ATS/ERS classification for lung adenocarcinoma was proposed. In this study, we investigated the clinicopathological impact of GLUT1 and Ki-67 expression on early-stage lung adenocarcinoma classified according to the IASLC/ATS/ERS classification. One hundred and five patients with completely resected stage IA lung adenocarcinoma were retrospectively classified into two groups, a 'non-invasive type' (n=31) or an 'invasive type' (n=74), based on the IASLC/ATS/ERS classification. GLUT1 and Ki-67 expression status was evaluated using immunohistochemistry. The epidermal growth factor receptor (EGFR) and KRAS mutation status was determined using PCR-based assays. Positive GLUT1 and Ki-67 expression and EGFR and KRAS mutations were detected in 28 (27%), 33 (31%), 51 (49%) and 5 (8%) cases, respectively. Positive GLUT1 expression was significantly associated with a wild-type EGFR and mutant KRAS status. A multivariate analysis revealed that positive GLUT1 expression was independently associated with the 'invasive type'. In multivariate analyses for overall survival (OS) and disease-free survival (DFS), positive Ki-67 and GLUT1 expression was the only independent factor for a poor OS (P=0.012) and DFS (P=0.040), respectively. In addition, when stratified according to the GLUT1 and Ki-67 status, double-positive cases had the poorest DFS and OS times, compared with the other categories. Positive GLUT1 expression is associated with the invasive character of early-stage lung adenocarcinoma and with early disease relapse. Our results strongly suggest that GLUT1 and Ki-67 play important roles in acquiring biological malignant potential in early-stage lung adenocarcinoma.
Keywords
early-stage lung adenocarcinoma
glucose transporter isoform 1
Ki-67
Published Date
2013-01
Publication Title
Oncology Reports
Volume
volume29
Issue
issue1
Start Page
133
End Page
140
ISSN
1021-335X
Content Type
Journal Article
Official Url
http://dx.doi.org/10.3892/or.2012.2087
Related Url
http://ousar.lib.okayama-u.ac.jp/metadata/51970
language
英語
File Version
publisher
Refereed
True
DOI
Web of Science KeyUT