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ID 52036
FullText URL
Author
Maki, Yuho
Ichimura, Kouichi
Furukawa, Masashi
Muraoka, Takayuki
Tanaka, Norimitsu
Ueno, Tsuyoshi
Toyooka, Shinichi
Abstract
High expression levels of glucose transporter isoform 1 (GLUT1) and Ki-67 are reportedly associated with malignancy-related clinicopathological factors in malignant tumors. Recently, a new histological IASLC/ATS/ERS classification for lung adenocarcinoma was proposed. In this study, we investigated the clinicopathological impact of GLUT1 and Ki-67 expression on early-stage lung adenocarcinoma classified according to the IASLC/ATS/ERS classification. One hundred and five patients with completely resected stage IA lung adenocarcinoma were retrospectively classified into two groups, a 'non-invasive type' (n=31) or an 'invasive type' (n=74), based on the IASLC/ATS/ERS classification. GLUT1 and Ki-67 expression status was evaluated using immunohistochemistry. The epidermal growth factor receptor (EGFR) and KRAS mutation status was determined using PCR-based assays. Positive GLUT1 and Ki-67 expression and EGFR and KRAS mutations were detected in 28 (27%), 33 (31%), 51 (49%) and 5 (8%) cases, respectively. Positive GLUT1 expression was significantly associated with a wild-type EGFR and mutant KRAS status. A multivariate analysis revealed that positive GLUT1 expression was independently associated with the 'invasive type'. In multivariate analyses for overall survival (OS) and disease-free survival (DFS), positive Ki-67 and GLUT1 expression was the only independent factor for a poor OS (P=0.012) and DFS (P=0.040), respectively. In addition, when stratified according to the GLUT1 and Ki-67 status, double-positive cases had the poorest DFS and OS times, compared with the other categories. Positive GLUT1 expression is associated with the invasive character of early-stage lung adenocarcinoma and with early disease relapse. Our results strongly suggest that GLUT1 and Ki-67 play important roles in acquiring biological malignant potential in early-stage lung adenocarcinoma.
Keywords
early-stage lung adenocarcinoma
glucose transporter isoform 1
Ki-67
Published Date
2013-01
Publication Title
Oncology Reports
Volume
volume29
Issue
issue1
Start Page
133
End Page
140
ISSN
1021-335X
Content Type
Journal Article
Official Url
http://dx.doi.org/10.3892/or.2012.2087
Related Url
http://ousar.lib.okayama-u.ac.jp/metadata/51970
language
英語
File Version
publisher
Refereed
True
DOI
Web of Sience KeyUT