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ID 58558
Author
Miyake, Tomoko Department of Dermatology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University ORCID Kaken ID
Iwatsuki, Keiji Department of Dermatology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Hirai, Yoji Department of Dermatology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Yamamoto, Takenobu Department of Dermatology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Hamada, Toshihisa Department of Dermatology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Fujii, Kazuyasu Department of Dermatology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
mamura, Hideaki Department of Pediatrics, Faculty of Medicine, University of Miyazaki
Morizane, Shin Department of Dermatology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University ORCID Kaken ID publons researchmap
Abstract
Epstein‐Barr virus (EBV) DNA load in the blood increases in posttransplant lymphoproliferative disorders and chronic active EBV infection. In this report, we analyzed the EBV DNA load in the peripheral blood mononuclear cells (PBMCs) and plasma of patients with hydroa vacciniforme (HV) and/or hypersensitivity to mosquito bites (HMB) to understand the clinical significance of EBV DNA load. All 30 patients showed high DNA loads in the PBMCs over the cut‐off level. Of 16 plasma samples, extremely high in two samples obtained from patients with hemophagocytic lymphohistiocytosis (HLH). The amount of cell‐free DNA in plasma was correlated to the serum levels of lactate dehydrogenase and inversely correlated to platelet counts. These results indicate that the EBV DNA load in PBMCs can provide one of the diagnostic indicators for HV and HMB and marked elevation of cell‐free EBV DNA in plasma might be related to cytolysis such as that observed in HLH.
Keywords
Epstein-Barr Virus DNA load
hydroa vaccniforme
hypersensitivity to mosquito bite
hemophagocytic lymphohistiocytosis
Note
This fulltext is available in Apr. 2021.
Published Date
2020-04-07
Publication Title
Journal of Medical Virology
Publisher
Wiley
ISSN
01466615
NCID
AA00702400
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
File Version
author
PubMed ID
DOI
Web of Science KeyUT
Related Url
isVersionOf https://doi.org/10.1002/jmv.25811
Funder Name
Ministry of Education, Culture, Sports, Science and Technology
Japan Agency for Medical Research and Development
助成番号
15k09744
17K16431
18K16063
17ek0109098
17ek0109124