JaLCDOI 10.18926/19764
Title Alternative Clinical studies on steroid-dependent intractable asthma
FullText URL 059_047_053.pdf
Author Kitani, Hikaru| Araki, Hiroyuki| Sudo, Michiyasu| Tanizaki, Yoshiro| Tsuji, Mituaki| Takahashi, Kiyoshi| Kimura, Ikuro|
Abstract ステロイド依存性重症難治性喘息56例について免疫アレルギー学的検討を行った。その結果41才以降発症のLate Onset Asthmaが約半数を占め,血清IgE値が比較的低値であり,ハウスダストに対しての皮内反応,特異的IgE抗体価,ヒスタミン遊離はいずれも全般的に低く,カンジダに対しての皮内反応,特異的IgG抗体価はむしろ比較的高く,肺機能では末梢気道閉塞の傾向が窺われ,臨床分類では,気管支攣縮+過分泌型,および細気管支閉塞型が多数を占める等の特徴を有することが明らかにされた。
Abstract Alternative Clinical studies on steroid-dependent intractable asthma were carried out in 56 patients relating to immuno-allergic aspects. 1. In most half of the patients with steroid-dependent intractable asthma, age at onset of the disease was 41 years old or over (so-called "Late Onset Asthma"). 2. The frequency of positive skin reaction for house dust was relatively low. whereas that for Candida was relatively high. 3. The serum IgE concentrations of these patients were in general low. Many patients showed low serum IgE concentrations of less than 300IU/ml. The concentrations of specific IgE antibodies for house dust and Candida albicans were also low. 4. The concentrations of specific IgG antibodies for Candida albicans were high compared to those for house dust. 5. Basophil histamine release induced by house dust and Candida albicans was not so remarkable in majoriy of these patients, while anti-IgE-induced histamine release from basophils ranged widely. 6. In these patients, small airway obstruction was suggested in ventilatory function test. 7. In clinical classificatin of asthma, type Ⅰa; bronchospasm type was a few, while type Ⅰb; hypersecretion and type Ⅱ; bronchiolor obstruction type were dominant in the cases studied here.
Keywords ステロイド依存性喘息 (Steroid-dependent asthma) 血清IgE (Serum-IgE) 特異的IgE (Specific lgE) 特異的IgG (Specific IgG) 中高年発症型喘息 (Late onset asthma)
Publication Title 環境病態研報告
Published Date 1988-08
Volume volume59
Start Page 47
End Page 53
ISSN 09133771
language 日本語
File Version publisher
NAID 120002309074
JaLCDOI 10.18926/19762
Title Alternative Atopic asthma in patients of middle or advanced age
FullText URL 059_042_046.pdf
Author Araki, Hiroyuki| Kitani, Hikaru| Sudo, Michiyasu| Tanizaki, Yoshiro|
Abstract 中高年令(41才以上)のアトピー型喘息患者の特徴を明らかにするために,アトピー型喘息患者88例を0~20才,21~40才,41~60才,61才以上の各年令別に分け,年令,性別,発症年令,既往歴,家族歴,末梢血好酸球,血清IgE値,皮内反応の各項目について検討を加えた。結果は,中高年のアトピー型喘息患者は1)その年代の全喘息患者に占める割合は低く,2)男性が多く,3)平均発症年令は高く,4)その他のアレルギー性疾患の既往歴を持たない症例が比較的多く,5)皮内反応では,ハウスダスト陽性率が比較的低く,カンジダ,アスペルギルスの陽性率は比較的高い傾向にあった。6)家族歴,末梢血好酸球,血清IgE値では,明らかな傾向は認められなかった。
Abstract Alternative In order to elucidate the characteristics of atopic asthma in patients of middle or advanced age (over 41 years old), 88 atopic asthmatic patients were divided into 4 groups according to their ages, 0~20, 21~40, 41~60 and over 61 years old, and age, sex, age of onset, past history, family history, number of peripheral eosinophils, serum IgE and skin test were compared among these groups. The results were as follows: Atopic ashmatic patients of middle or advanced age were 1) less frequent in all asthmatic patients of same age group, 2) more frequent in males than in females, 3) higher in averaged age of onset, 4) more frequent in cases without other allergic past histories, 5) less frequently positive to house dust and more frequently positive to Candida and Aspergillus in skin test, 6) not different in family history, number of peripheral eosinophils and serum IgE compared to other groups.
Keywords アトピー (Atopy) 中高年令者 (patients of middle or advanced age) 喘息 (asthma)
Publication Title 環境病態研報告
Published Date 1988-08
Volume volume59
Start Page 42
End Page 46
ISSN 09133771
language 日本語
File Version publisher
NAID 120002309184
JaLCDOI 10.18926/19758
Title Alternative Separation of paripheral leukocytes by counterflow centrifugation elutriation
FullText URL 059_037_041.pdf
Author Sudo, Michiyasu| Matsubara, Fumie| Araki, Hiroyuki| Kitani, Hikaru| Tanizaki, Yoshiro|
Abstract JE-6B rotor(Beckman)を用いてcounterflow centrifugation elutriationによる末梢血白血球の分離を試み,若干の検討を加えた。1.flow rateが低い場合はリンパ球が大部分を占めたが,flow rateの増加とともに頻度は減少した。2. flow rateの増加とともに,好塩基球の頻度が増加し,9-10ml/minでは頻度のみでなく細胞数の増加も認められた。各fractionにおけるヒスタミン含有量も同様の傾向が認められた。3.好中球のpeakはflow rate 13ml/minであり以後減少を示した。4.最終段階で好酸球が増加傾向を示しChamber内で最も高値を示した。以上の結果よりcounterflow centrifugation elutriationによる末梢血白血球細胞分離は,in vitroにおける実験に有用な手段である可能性が示唆された。
Abstract Alternative Separation of peripheral leukocytes was carried out in 5 healthy subjects by counterflow centrifugation elutriation with JE-6B rotor. 1. Number of lymphocytes was predominant at low flow rate (4.5ml/min) of counterflow centrifugation elutriation. 2. As flow rate was increased (9-10ml/min), the purity and number of basophils, and histamine content in the fraction were gradually increased. 3. The purity and number of neutrophils were gradually increased, and the purity was reached the peak at 13ml/min. 4. The purity and number of eosinophils were gradually increased at the late stage of the centrifugation elutriation. The results obtained here might suggest that cell separation by counterflow centrifugation elutriation is more useful for experiments, especially allergy testing, in vitro.
Keywords 逆流負荷遠心法 (Counterflow centrifugation elutriation) JE-6Bローター (JE-6B rotor) 細胞分離 (Cell separation) 好塩基球 (Basophils)
Publication Title 環境病態研報告
Published Date 1988-08
Volume volume59
Start Page 37
End Page 41
ISSN 09133771
language 日本語
File Version publisher
NAID 120002309189
JaLCDOI 10.18926/19755
Title Alternative 気管支喘息および慢性気管支炎患者における抗ヒトIgEによる好塩基球からのヒスタミン遊離
FullText URL 059_031_036.pdf
Author Tanizaki, Yoshiro| Sudo, Michiyasu| Kitani, Hikaru| Araki, Hiroyuki| Tsuji, Mitsuaki| Takahashi, Kiyoshi| Kimura, Ikuro|
Abstract Histamine release from basophils induced by anti-IgE was studied in 8 patients with chronic bronchitis and 50 patients with bronchial asthma by analyzing doseresponse curves. As the result, there were no significant differences in maximum percent histamine release from basophils among three groups of healthy subjects (24.7± 14.2%), patients with chronic bronchitis (27.7±22.1%) and those with bronchial asthma (28.4±17.0%). In the patients with bronchial asthma, the maximum percent histamine release was higher in accordance with higher serum IgE levels, and low maximum percent release was observed in patients with intrinsic asthma (14.1±7.2%). Study of dose-response curves of anti-IgE-induced histamine release showed that a negative slope from E(2) to E(1) was observed in both healthy subjects and patients with chronic bronchitis. The majority of asthmatics with serum IgE levels of 501IU/ml or over showed a positive slope from E(2) to E(1).
Abstract Alternative 気管支喘息50例,慢性気管支炎8例を対象に,抗ヒトIgE添加時の好塩基球からのヒスタミン遊離を全血法により行ない,その臨床的評価について検討を加えた。抗ヒトIgE海底時のMax % histamine releaseの平均は,健康人24.7±14.2%,慢性気管支炎27.7±22.1%,気管支喘息28.4±17.0%であり,3者間に有意の差はみられなかった。すなわち,抗ヒトIgE添加により健康人や慢性気管支炎患者の好塩基球からも有意のヒスタミン遊離が見られた。気管支喘息のなかでは,内因性喘息症例においてヒスタミン遊離(14.1±7.2%)の低い傾向が見られた。Dose-response curveの検討では,健康人,慢性気管支炎症例では全例E(2)からE(1)へかけてのnegative slopeを示した。気管支喘息症例では,血清IgE値500IU/ml以下の症例ではnegative slopeを示す症例が多く,一方501IU/ml以上の症例ではpositive slopeを示す症例がより多く見られた。
Keywords Basophil response (好塩基球の反応性) Anti-lgE (抗ヒトIgE) Histamine release (ヒスタミン遊離) chronic bronchitis (慢性気管支炎) bronchial asthma (気管支喘息)
Publication Title 環境病態研報告
Published Date 1988-08
Volume volume59
Start Page 31
End Page 36
ISSN 09133771
language 英語
File Version publisher
NAID 120002309114
JaLCDOI 10.18926/19752
Title Alternative Early diagnosis of pancreatic cancertrial of a mass screening test for detecting early pancreatic cancer
FullText URL 059_024_030.pdf
Author Matsumoto, Shuji| Ochi, Koji| Irie, Seiji| Takeda, Masahiko| Tanaka, Juntaro| Harada, Hideo|
Abstract 膵癌を治癒に導くためには早期診断,早期切除以外に方法はない。そこで,無症状者のなかから早期膵癌を発見するためのスクリーニング法を検討するためProspective studyを実施した。人間ドック目的の来院患者を主とする三朝分院外来患者776名を対象とし,一次スクリーニング検査として,血清アミラーゼ,エラスターゼⅠ,CA19-9,アルカリフォスファターゼ,γ-GTP,血糖値の測定および腹部超音波検査を施行し,異常者に対して二次スクリーニングとして腹部超音波検査の再精査およびERCPを施行した。その結果,早期膵癌1例および進行膵癌2例を検出し,膵癌発見率は0.39% と満足のいく結果が得られた。しかし一次スクリーニング検査の要精検率は46% と高値を示したこと,一次スクリーニング検査の費用は胃集検の約3.3倍,二次スクリーニング検査の費用は胃精査の約2.6倍かかることからcost-benifitの面で問題となった。また見逃し症例の有無をモニターするためfollow upも今後の問題として残った。
Abstract Alternative There is no other way of curing pancreatic cancer than early diagnosis and resection. However, an effective protocol has not been established for detecting early pancreatic cancer among asymptomatic populations by means of a mass screening test. Therefore, a prospective study was attempted on 776 patients who came to Medical Clinic of Misasa Branch Hospital, Okayama University Medical School mostly for a routine annual check-up. The following tentative protocol was proposed, based on the retrospective analyses of our 13 patients with early pancreatic cancer: (1) a first step test includes serum amylase, elastase Ⅰ, alkaline phosphatase, r-GTP, carcinoembryonic antigen, fasting blood sugar and routine abdominal ultrasonography (US); (2) a second step test includes thorough abdominal US with various kinds of probes and patients' positioning which was performed on individuals with abnormal findings on the first step test, (3) a third step test includes ERCP which was performed on individuals with abnormal or questionable findings on the second step test. Further detail examinations were performed when ERCP was abnormal or questionable. Consequently 357 patients (46% of the total 776 patients) underwent thorough US and 45 patients (5.8%) underwent ERCP. ERCP findings included pancreatic cancer in two patients, suspect of pancreatic cancer in three, advanced chronic pancreatitis in two, equivocal as for chronic pancreatitis (according to the Cambridge classification) in nine, and normal in 29. Final diagnosis was early pancreatic cancer in one patient, advanced pancreatic cancer in two, and calcified chronic pancreatitis in two; detection rate of pancreatic cancer (0.39%) in this series was slightly higher than that usually reported with a mass screening test for stomach cancer. From a cost-benefit point of view, however, examinations for the pancreas cost 2.6 times as much as those for the stomach. Further studies are needed (1) to refine the protocol, (2) to improve cost-benefit efficiency, (3) and also to confirm by follow-up that no cases of pancreatic cancer have passed through the test undetected.
Keywords 膵集検 (Mass screening) 早期膵癌 (Early pancreatic cancer) 膵癌の早期診断 (Early diagnosis of pancreatic cancer)
Publication Title 環境病態研報告
Published Date 1988-08
Volume volume59
Start Page 24
End Page 30
ISSN 09133771
language 日本語
File Version publisher
NAID 120002309153
JaLCDOI 10.18926/19750
Title Alternative Clinical evaluation of endoscopic ultrasonography (EUS) in the diagnosis of gastric disease.
FullText URL 059_017_023.pdf
Author Ochi, Koji| Harada, Hideo| Matsumoto, Shuji| Irie, Seiji| Takeda, Masahiko| Tanaka, Juntaro|
Abstract ラジアルセクタ式超音波内視鏡(EUS)を,15例の胃疾患患者に用い,その有用性を検討した。胃癌の深達度診断は併存潰瘍を有するm癌の1例をsm癌とした以外は,いずれも正診であり,胃癌の深達度診断にEUSが有用であることが示唆された。その他,胃粘膜下腫瘍の占拠部位や発育様式の診断や壁外性圧排との鑑別など胃疾患の診断にEUSの有用性が示唆され,文献的考察を加えて報告した。
Abstract Alternative We performed EUS in seven cases with gastric cancer, one with gastric malignant lymphoma, two with submucosal tumor of the stomach (SMT), two with tumourous compression by extra-gastric organs and three with others. Except one case with early gastric cancer, the depth of cancerous lnvasion was correct1y diagnosed by EUS. It was posible to detect which layer had SMT in the 5 layer strcture of the gastric wall by EUS and it was helpful in determination of histological origin of SMT. Furthermore EUS was able to make the differential diagnosis between SMT and tumourous compression by extra gastric organ. Our result showed that EUS was a useful procedure in the diagnosis of gastric diseases.
Keywords 超音波内視鏡 (Endoscopic ultrasonography) 胃癌 (Gastric cancer) 胃粘膜下腫瘍 (Submucosal tumor of the stomach) 癌深達度診断 (Diagnosis of the depth of cancerous invasion)
Publication Title 環境病態研報告
Published Date 1988-08
Volume volume59
Start Page 17
End Page 23
ISSN 09133771
language 日本語
File Version publisher
NAID 120002309109
JaLCDOI 10.18926/19747
Title Alternative Characteristic pancreatographic findings in chronic pancreatitis and their diagnostic value. …Studies on post mortem pancreas…
FullText URL 059_012_016.pdf
Author Tanaka, Juntaro| Matumoto, Shuuji| Ochi, Kouji| Irie, Seiji| Takeda, Masahiko| Harada, Hideo|
Abstract 慢性膵炎25例および対照として正常例125例計150例の新鮮剖検膵を用いて膵管造影を行い,X線所見と同部位の組織所見とを厳密に対比させ,慢性膵炎における各X線所見の診断学的価値を検討した。その結果,主膵管像では不整拡張像,硬化+辺縁不整像,狭窄+辺縁不整像が,分枝像では不整拡張像および不整配列像が,positive predictive value(PPV),specificity(Sf),negative predictive value(NVP)ともに77.1~100% の高率を示した。しかしsensitivity(St)は,2.1~18.1% と低率であった。したがって,これらの所見は慢性膵炎を診断する上で組織予見性および特異性に優れた診断的価値のあるX線所見と言える。しかし一方では軽症の慢性膵炎の検出能はあまりよくないという限界が膵管造影法にはある。
Abstract Alternative Postmortem pancreas tissue was prepared within 6 hours of death for the comparative study of pancreatographic findings and histological findings to define characteristic pancreatographic findings of chronic pancreatitis and determine their diagnostic value. Pancreas tissue was obtained from 25 patients with chronic pancreatitis and 125 with a normal pancreas. Among various pancreatographic findings, irregular dilatation and irregular arrangement of the branches of the pancreatic duct, and also irregular dilatation, rigidity with irregular margin and stenosis with irregular margin of the main pancreatic duct showed the highest sensitivity. specificity, positive predictive value and negative predictive value and conseqently had the highest diagnostic valus. However, the sensitivity was not high enough, indicating that the above pancreatographic findings could be absent at the site of positive histological findings in mild chronic pancreatitis.
Keywords 慢性膵炎 (chronic pancreatitis) 膵管造影像 (pancreatogpaphy)
Publication Title 環境病態研報告
Published Date 1988-08
Volume volume59
Start Page 12
End Page 16
ISSN 09133771
language 日本語
File Version publisher
NAID 120002309156
JaLCDOI 10.18926/19745
Title Alternative Maternal swimming at Misasa Hospital Of Okayama University Medical School First report. Recognition of the pregnant women to maternity swimming
FullText URL 059_008_011.pdf
Author Okuda, Hiroyuki| Suga, Kiyohiro| Sakata, Junko| Yosida, Sachie| Mifune, Masaaki| Tanizaki, Yoshiro|
Abstract 妊婦のスポーツに対する考え方は近年まで比較的消極的であったが,最近マスコミに取り上げられるようになり,妊婦水泳・エアロビクスダンス等は全国的にもかなり普及していると思われる。今回外来通院患者を対象に妊婦水泳に関するアンケート調査を行った結果,大多数のものが関心を持ち,また実施希望を持っていることが判明したのでその概要を報告する。
Abstract Alternative The sports have been contraindication for pregnant women till resent years. Since Dr. Murooka reported the safety and the effectiveness of maternity swimming in 1978. maternity swimming have been taken up and fasionarised by mass media. And then maternity swimming becomes popular in our all over the country. Now we made inquiries about maternity swimming to 25 pregnant women in our outpatients clinic. (Results) 1. Eightyfour percent of them were interested in maternity swimming. 2. Eightyeight percent of them wanted to swim. 3. Most of them had little knowledge about tocological effectiveness of maternity swimming. (Conclusion) It is nessesary that the enlightenment and the active management of maternity swimming by obstetricians.
Keywords 妊婦水泳 (Maternity swimming)
Publication Title 環境病態研報告
Published Date 1988-08
Volume volume59
Start Page 8
End Page 11
ISSN 09133771
language 日本語
File Version publisher
NAID 120002308990
JaLCDOI 10.18926/19743
Title Alternative Spe therapy for chronic respiratory disease-in subjects admitted in 1987.
FullText URL 059_001_007.pdf
Author Tanizaki, Yoshiro| Sudo, Michiyasu| Kitani, Hikaru| Araki, Hiroyuki|
Abstract 1987年1月より12月までの1年間に当院へ入院した慢性呼吸器疾患患者52例を対象に,その背景因子,免疫アレルギー学的要素および温泉療法の臨床効果について検討を加えた。1.対象52例のうちわけは,気管支喘息37例,瀰漫性汎細気管支炎3例,慢性咳嗽3例,アレルギー性肉芽腫性血管炎2例,慢性気管支炎2例,過敏性肺臓炎2例,気管支拡張症,肺気腫,広汎性肺結核症各1例であった。2.これら52症例のうち,温泉療法を受けた症例は36例(69.2%)であった。3.対象症例の地域分布と温泉療法を受けた症例との関係では,鳥取県内の入院症例(26例)で温泉療法を受けた症例は11例(42.3%)であり,県外(遠隔地)からの入院症例(26例)で温泉療法を受けた症例は25例(96.2%)であった。4.温泉療法の臨床効果では,気管支喘息では30例中25例(83.3%)で有効であり,その他1瀰漫性汎細気管支炎,アレルギー性肉芽腫性血管炎,気管支拡張症などで有効であった。
Abstract Alternative Backgrounds, immunoallergological characteristics and clinical effects of apa therapy were examined in patients with chronic respiratory diseases admitted at Misasa Branch Hospital in 1987. 1. Fifty five patients with chronic respiratory diseases comprised 37 patients with bronchial asthma, 3 with diffuse panbronchiolitis, 3 with chronic cough, 2 with allergic granulomatous angitis, 2 with chronic bronchitis, 2 with hypersensitivity pneumonitis, each 1 with bronchiectasia, pulmonary emphysema and lung tuberculosis. 2. Thirty six patients (69.2%) out of the 52 cases had spa therapy. 3. Out of 22 patients coming from Tottori prefecture, 11 cases (42.3%) received spa therapy. On the other hand, spa therapy was carried out for 25 cases (96.2%) out of the 26 cases coming from the other prefectures (long distant areas). 4. Spa therapy was effective in 25 cases (83.3%) out of the 30 patients with bronchial asthma. Spa therapy was also effective for patients with diffuse panbronchiolitis, allergic granulomatous angitis and bronchiectasia.
Keywords 気管支喘息 (Bronchial asthma) 瀰漫性汎細気管支炎 (Diffuse panbronchiolitis) 気管支炎 気管支肺胞洗浄法 (Bronchoalveolar lavage) 温泉療法 (Spa therapy)
Publication Title 環境病態研報告
Published Date 1988-08
Volume volume59
Start Page 1
End Page 7
ISSN 09133771
language 日本語
File Version publisher
NAID 120002309207
Author 高田 信江|
Published Date 1987-08
Publication Title 環境病態研報告
Volume volume58
Content Type Others
JaLCDOI 10.18926/19740
FullText URL 058_066_068.pdf
Author 山田 武司|
Publication Title 環境病態研報告
Published Date 1987-08
Volume volume58
Start Page 66
End Page 68
ISSN 09133771
language 日本語
File Version publisher
NAID 120002309198
Author Matsubara, Fumie| Sudo, Michiyasu| Tanizaki, Yoshiro| Morinaga, Hiroshi|
Published Date 1987-08
Publication Title 環境病態研報告
Volume volume58
Content Type Data or Dataset
JaLCDOI 10.18926/19735
Title Alternative Spa therapy for bronchial asthma 2. Clinical and fundamental evaluation procedures
FullText URL 058_035_039.pdf
Author Tanizaki, Yoshiro| Sudo, Michiyasu|
Abstract 気管支喘息に対する温泉療法の効果が,これまでどのような評価方法により判定されてきているのかについて,若干の文献的考察を加えた。効果に対する評価方法は,臨床的評価と作用機序と関連した評価方法とに分けて考えることができる。臨床的評価方法としては,自,他覚症状の改善,同時に使用された薬剤の減量の程度,あるいは,肺機能検査の各パラメーターの変動の比較などの方法により行なわれている。一方作用機序と関連した評価では,喘息の発症機序とある程度関連した温泉療法の作用を中心に検討が加えられている。例えば,喘息の発症機序として重要な位置を占める免疫アレルギー反応,自立神経系,内分泌系などと関連した指標を用いて,その変動を観察することによって,効果を明らかにしようとする試みがなされている。これらの検討は極めて意義深いが,なお今後IgE系反応や気道の過敏性との関連 などについての追求が必要であるように考えられる。
Abstract Alternative Evaluation procedures for effectiveness of spa therapy on bronchial asthma were discussed according to the reports published. The evaluation procedures could be divided into tow groups : procedures by clinical observations and procedures by findings relating to action mechanisms of spa therapy. Clinical evaluations have been performed by subjective and objective symptoms, the degree of reduction of drugs used for treatment of bronchial asthma, and improvement of each parameter in ventilatory function test. The results obtained by these procedures are frequently reported as clinical observations. On the other hand, evaluations based on the findings relating to action mechanisms of spa therapy have been carried out as follows : 1) observations for immuno-allergic reactions which play an important role in pathogenic mechanisms of bronchial asthma. 2) observations for autonomic nerve system, and 3) for endocrine glands, which have a close correlation with onset mechanisms of bronchial asthma. The results obtained by these findings before and after spa therapy are much interesting, and should be investigated furthermore.
Keywords 温泉療法 (spa therapy) 気管支喘息 (bronchial asthrna) 免疫アレルギー反応 (immuno-allergic reaction) 自律神経系 (autonomic nerve) 内分泌系 (endocrine)
Publication Title 環境病態研報告
Published Date 1987-08
Volume volume58
Start Page 35
End Page 39
ISSN 09133771
language 日本語
File Version publisher
NAID 120002309078
JaLCDOI 10.18926/19731
Title Alternative Spa therapy for bronchial asthma 1. Climatotherapy, its clinical effects
FullText URL 058_031_034.pdf
Author Tanizaki, Yoshiro| Sudo, Michiyasu|
Abstract 気管支喘息に対する温泉療法,特に温泉所在地(保養地)の環境,すなわち気候条件の喘息に対する影響について,文献的考察を加えた。気候療法としては,主として山岳気候,海洋性気候,洞窟気候などが,喘息の治療に応用されている。これらの気候は,いずれも喘息に対して有効的に作用することが示されているが,それぞれの特徴を持っている。例えば,山岳気候は酸素分圧が低いこと,水蒸気圧が低いことなどが特徴であり,そのため生体がそれに適合するためにはある程度の時間が必要となる。一方海洋性気候は,海塩粒子を含んでおり,海水エロゾル中のカルシウムやマグネシウムなどが良い影響を与えると考えられている。また洞窟気候は,水分含量が均一であり,電解質,特に陰イオンが多く,これが粘膜活性や浄化活性を亢進させると言われている。またいずれの気候療法も,副腎皮質機能の活性化をもたらすと考えられている。
Abstract Alternative Spa therapy includes influence of environmental factors, especially climate around the place at which spa therapy is performed. In the present article, the effects of environmental climate around the hot springs on bronchial asthma were discussed according to the reports published. Mountain climate, sea climate and underground climate are reported to be effective for the therapy of bronchial asthma. Although these climates have shown remarkable effectiveness on bronchial asthma, each of them has climatic characteristics in treatment for bronchial asthma. Mountain climate has low content of oxygen and low vapor pressure, and patients with bronchial asthma require several weeks to adapt themselves for the climate. Sea climate is rich in cations and anions, and Ca(2+) and Mg(2+) included in sea water aerosol act beneficially on mucous membrane of airways in patiepts with bronchial asthma. Underground climate includes a lot of anions, which activate the activity of mucous membrane and ability of clearance of airways. Each climate also activate the function of adrenal glands.
Keywords 気候療法 (climatotherapy) 気管支喘息 (bronchial asthrna) 山岳気候 (mountain climate) 海洋性気候 (sea climate) 洞窟気候 (underground climate)
Publication Title 環境病態研報告
Published Date 1987-08
Volume volume58
Start Page 31
End Page 34
ISSN 09133771
language 日本語
File Version publisher
NAID 120002308993
JaLCDOI 10.18926/19727
Title Alternative Clinical effects of serial artificial CO(2) baths on degenerative disorders in consideration of the improved tissue perfusion.
FullText URL 058_022_030.pdf
Author Komoto, Yoshiaki| Kohmoto, Tomoji| Sunakawa, Mitsuru| Yagi, Nobuko| Yorozu, Hidenori| Matsumoto, Yasunobu|
Abstract 組織循環の良不良は,結合織の退行性病変の予後に大いに影響をおよぼすものである。人工炭酸泉を用いた実験的検討で,すでに組織循環の30 % 増加を認めており,臨床的治験により好傾向を示す結果を得つつある。結合織病変を主とする慢性疾患4症例の治験前後に局所組織流量を測定して評価することができた。局所組織流量は医用質量分析装置を介したオンラインシステムで測定計算した。人工炭酸浴は,炭酸ガスキャビン,および人工炭酸浴剤浴を用いた。人工炭酸泉浴は,1カ月より1年におよび,それぞれ自覚症状の著名な改善と,組織流量の増加を定量しえた。人工炭酸泉の連浴による組織流量の改善は、結合織の退行性病変に有効に作用するものである。
Abstract Alternative Tissue perfusion plays an important role in prognosis of the deteriorating connective tissue disorders. Tissue perfusion was evaluated before and after CO(2) treatment on the patients with connective tissue disorders by means of medical mass spectrometer. CO(2) treatment was performed in 2 ways ; one was with CO(2)-cabine, 20 litres per minute at 40℃ for 20 minutes, and the other was with an artificial CO(2) bathing prepared with 2 tablets of BUB-KAO, a 50 g sodium hydrogencarbonate and succinic acid tablet, in 280-litre-tub at 40℃ for 20 minutes. Case 1, 33-year-old female, suffering from chronic rheumatic arthritis with rheumatic thromboangiitis obliterans in the left 5th toe. Main arterial trees were found intact arteriographically. Her joint pain and muscle stiffness have been improved markedly after CO(2) treatment with cabin every day for one month though every medicine for rheumatism made little effect. Case 2, 46-year-old female, suffered from progressive systemic scleroderma. Major blood supply was found not blocked in upper extremities arteriographically. Tissue perfusion was found poor in muscle tissue of each forearm before CO(2) treatment with cabin, whereas an improved tissue perfusion was confirmed after one month of serial CO(2) treatment, leading to ameliorate persistent muscle stiffness, though every medicine for her made slow effect. Case 3, 48-year-old female, suffering from the weakness in strength with no positive laboratory findings of connective tissue disorders. Tissue perfusion has been found quite improved following serial artificial CO(2) bathings for 12 months, being able to work hard every day as a nurse. Serial CO(2) bathing is thought to be very useful in ameliorating the symptoms of deteriorating connective disorders by virtue of an improved tissue perfusion.
Publication Title 環境病態研報告
Published Date 1987-08
Volume volume58
Start Page 22
End Page 30
ISSN 09133771
language 日本語
File Version publisher
NAID 120002309112
JaLCDOI 10.18926/19721
Title Alternative The simplified method of measuring Radon in mineral waters by the liquid scintillation counter.
FullText URL 058_017_021.pdf
Author Mifune, Masaaki|
Abstract 鉱泉水中のラドンを測定するため,抽出法を省略し,少量の試料水を直接液状シンチレーターに溶解し,液体シンチレーション計数器を用いて放射能を測定し,次いで簡単な計算法により試料水中のラドン濃度を計算する簡易定量法を試みた。本法を用いて一鉱泉水のラドンを反復測定した際の精度は,σ=0.136nCi/l,CV=5.77 % ,(x=2.36n Ci/l)であった。次に本法でのRnの最少検出量は,0.2nCi/lである。原法と本法とを用いて得られた測定値の間には,r=0.996,y=0.818x+0.875なる相関関係が成立した。本法を使用すると,簡単な予備処理後,極短時間内にラドンの測定が可能なため,花崗岩地域の井水,鉱泉水中のラドンを定量するためには,有用な方法である。
Abstract Alternative Radon in mineral waters was determined with simplicity by newly developed method. In this method, 2.0mℓ of water sample was directly mixed with 15 mℓ of Hionic-Fluor in a vial, which was then filled up with additional Hionic-Fluor ; 190 minutes were allowed for the radioactivity to equilibrate. The radioactiviity of Radon was measured by the Liquid Scintillation Counter (Tri-Carb 460C). Radon content was easily calculated with the proposed formula by an electric desk calculater. The reproducibility was proved CV=5.77 % ; the lowest detection limit was 0.2 nCi/l. An adequate correlation was obtained from the results of measurements compared with the original method ; r=0.996, y=0.818x×0.875.
Keywords 鉱泉水 (Mineral waters) ラドン (Radon) 放射能泉 (Radioactive springs) 液体シンチレーション計数器 (Liquid scintillation counter)
Publication Title 環境病態研報告
Published Date 1987-08
Volume volume58
Start Page 17
End Page 21
ISSN 09133771
language 日本語
File Version publisher
NAID 120002309126
JaLCDOI 10.18926/19715
Title Alternative Effect of spa-drink therapy on exocrine pancreatic function
FullText URL 058_012_016.pdf
Author Matsumoto, Shuji| Harada, Hideo| Ochi, Koji| Takeda, Masahiko| Tanaka, Juntaro| Senou, Toshinobu| Irie, Seiji| Ishibashi, Tadaaki| Kimura, Ikuro|
Abstract 膵外分泌機能におよぼす飲泉(三朝温泉水)の効果を飲泉群および非飲泉群を対象として検討した。膵外分泌機能検査法としては,糞便中キモトリプシン活性比色測定法(モノテストカイモトリプシン)を用いた。その結果,糞便中キモトリプシン活性は,飲泉開始2週後に40 % の患者で上昇し,4週後は2週後と変わらなかった。以上より,2週間の飲泉は膵外分泌機能を改善させる効果があることがわかった。
Abstract Alternative The effect of spa-drink therapy (Misasa hot spring) on exocrine pancreatic function was studied on 18 patients after their physical and psychological conditions were stabilized about two weeks following hospitalization. Patients were randomly divided into two groups : eight patients into a control group (continuance of spa-bathing) and 10 patients into a spa-drink therapy group (continuance of spa-bathing plus commencement of spa-drink therapy). Spa-drink therapy refers to drinking 200mℓ of warm spa-water (42℃) two times a day : between meals in the morning and in the afternoon. Exocrine pancreatic function was evaluated by fecal chymotrypsin activity, using a colorimetric method (Boehringer-Mannheim). Following results were obtained : 1) With 2-week's spa-drink therapy, fecal chymotrypsin activity was significantly enhanced in 40 % of the patients, while none of the controls showed an increase in fecal chymotrypsin activity. 2) Fecal chymotrypsin activity at the time of 4 weeks was similar to that obtained at the time of 2 weeks in both groups. In conclusion, spa-drink therapy for 2 weeks was effective for the enhancement of exocrine pancreatic function.
Keywords 糞便中キモトリプシン活性 (Fecal chymotrypsin activity) 飲泉療法 (Spa-drink therapy) 膵外分泌機能 (Pancreatic exocrine function) 膵 (Pancreas) 酵素 (Enzyme)
Publication Title 環境病態研報告
Published Date 1987-08
Volume volume58
Start Page 12
End Page 16
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002309038
JaLCDOI 10.18926/19710
Title Alternative Study on anti-allergic action of Terfenadine
FullText URL 058_005_011.pdf
Author Tanizaki, Yoshiro| Komagoe, Haruki| Sudo, Michiyasu| Kitani, Hikaru|
Abstract 選択的H(1)受容体拮抗薬であるTerfenadineの抗アレルギー作用,特にIgE系反応によるヒスタミン,およびCa ionophore A23187による好中球からのleukotrienes遊離に対する抑制作用を,ヒト末梢血白血球を用いて検討した。1.Terfenadineは,抗ヒトIgE刺激による健康人好塩基球および特異抗原刺激による気管支喘息患者好塩基球からのヒスタミン遊離に対して,全血法でのin vitro添加実験では有意の抑制作用を示さなかった。 2.洗浄白血球法によるin vitro添加実験では,Terfenadineは特異抗原および抗ヒトIgE刺激時の気管支喘息患者好塩基球からのヒスタミン,Ca ionophore A23187刺激時のleukotriene B(4)遊離に対して有意の抑制効果を示した。3.Terfenadineの内服によるin vivoの抑制実験では,IgE系反応による健康人および気管支喘息患者好塩基球からのヒスタミン遊離に対して有意の抑制効果は見られなかったが,特異抗原による皮膚反応に対しては明らかな抑制作用が観察された。以上より,Terfenadineは,組織肥満細胞および組織へと遊走してきた好塩基球に対してはある程度の抑制作用を有しているものと考えられた。
Abstract Alternative Anti-allergic action of terfenadine, one of the H(1) receptor inhibitors, was examined by human basophil histamine release induced by anti-IgE or a specific allergen (house dust), and the release of leukotriens from leucocytes stimulated by Ca ionophore A23187. 1. Terfenadine did not inhibit the release of histamine from basophils of healthy subjects induced by anti-IgE, and also of patients with bronchial asthma induced by house dust when the in vitro examination was performed by a whole blood method. 2. Histamine release from basophils of patients with bronchial asthma was significantly inhibited when washed leucocytes was preincubated with terfenadine in vitro. The release of LT B(4) from leucocytes was also inhibited. 3. In vivo examination of inhibitory action of terfenadine showed no effect on basophil histamine release of healthy subjects by anti-IgE and of asthmatic subjects by house dust, although skin test by house dust in these subjects was inhibited 60 min after administration in vivo. These results show that terfenadine inhibits the release of chemical mediators from tissue mast cells, and basophils migrating into local allergic sites.
Keywords 夕一フェナンジン (Terfenadine) lgE系反応 (IgE-mediated reaction) ヒスタミン (histamine) 好塩基球 (basophils)
Publication Title 環境病態研報告
Published Date 1987-08
Volume volume58
Start Page 5
End Page 11
ISSN 09133771
language 日本語
File Version publisher
NAID 120002309197
JaLCDOI 10.18926/19706
Title Alternative Short term effect of spa-water on gastric mucosal blood flow
FullText URL 058_001_004.pdf
Author Tanaka, Juntarou| Matumoto, Shuuji| Senou, Toshinobu| Irie, Seiji| Ochi, Kouji| Takeda, Masahiko| Harada, Hideo|
Abstract 臓器反射スペクトル法と内視鏡を併用して胃粘膜血流を測定し,当院温泉水飲用の消化機能に対する基礎的検討を胃粘膜血流を指標に行なった。温泉水の対照として空気と白湯を選び3群に分け検討した。その結果,温泉水は空気に比し胃粘膜血流を増加させる作用を有していることが示唆された。また温泉水は部分的ではあるが白湯にくらべても胃粘膜血流を増加させる作用があることが示唆された。よって飲泉療法の消化器疾患に対する臨床的有用性が胃粘膜血流の面からもうかがわれた。
Abstract Alternative Short-term effects of spa-drink therapy on gastric mucosal blood flow were evaluated by an endoscopic organ reflex spectrophotometry, using Olympus XQ-10. Thirty-four subjects were randomly divided into three groups : 10 subjects for warm spa-water (40±C) infusion group, 10 subjects for warm tap-water infusion group, and 14 subjects for warm air infusion group. Intragastric infusion of water or air was performed through the fiberscopic infusion channel. Gastric mucosal blood flow was determined just before and 10 min after the infusion on the three points of gastric mucosa : lesser curvature of the angle, the antrum and the pylorus. Following results were obtained : 1) Spa-water exerted a beneficial effect on gastric mucosal blood flow as compared to air. The difference was statistically significant on all of the three points. 2) Spa-water tended to exert a beneficial effect on gastric mucosal blood flow as compared to tap-water. The difference, however, was significant only on the mucosa of the gastric antrum. In conclusion, it was suggested that spa-drink therapy was useful for the treatment of chronic gastritis and gastric ulcer in which impairment of gastric mucosal blood flow plays an important pathogenetic role. Studies on the long-term effects of spa-drink therapy on the gastric mucosal blood flow are now in progress.
Keywords 飲泉療法 (Spa-drink therapy) 消化器機能 (Digestive function) 胃粘膜血流 (Gastric mucosal blood flow) 臓器反射スペクトル法 (Organ reflex spectrophotometry)
Publication Title 環境病態研報告
Published Date 1987-08
Volume volume58
Start Page 1
End Page 4
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002309081
Author 中村 寿美江| 石湯 和子| 谷本 悦子|
Published Date 1986-07
Publication Title 環境病態研報告
Volume volume57
Content Type Others