Author 山田 香須美|
Published Date 1986-07
Publication Title 環境病態研報告
Volume volume57
Content Type Others
JaLCDOI 10.18926/19700
Author 山田 武司|
Publication Title 環境病態研報告
Published Date 1986-07
Volume volume57
Start Page 108
End Page 111
ISSN 09133771
language 日本語
File Version publisher
Author Inoue, Taeko| Tanizaki, Yoshiro| Morinaga, Hiroshi|
Published Date 1986-07
Publication Title 環境病態研報告
Volume volume57
Content Type Data or Dataset
JaLCDOI 10.18926/19697
Title Alternative Angiography system combined with Toshiba BV-type X-TV Equipment. 2. Stereo-magnification system.
FullText URL 057_061_066.pdf
Author Akiyama, Tsuneo| Nakai, Mutsuo| Matsushima, Kishio|
Abstract 我々は,既設の消化管診断用X線TV装置(東芝BV型)を使用した立体拡大撮影システムを検討した。1.消化管診断用X線TV装置の透視天板の高さが一定であるため,従来のフィルムチェンジャー(AOT)では不可能であったが,上下動可能なフィルムチェンジャー(福放FC-10L特)を改良試作したことで最大2倍までの立体拡大撮影が可能となった。2.透視観察から撮影へ,コンタクト撮影から拡大連続撮影,立体撮影から立体拡大連続撮影へと併用して行うことが非常に簡単にできて被検者の負担軽減と多目的使用が可能となった。3.観察条件と立体感については,拡大率を変化させて,その立体感について検討した結果は、観察距離については,各拡大率における立体視しやすい距離は存在し,拡大率が2倍の場合には,観察距離を大きくするほど立体感も増加し,立体視し易い傾向が示された。
Abstract Alternative Angiography of the head and abdominal region gives a good deal of peculiar information for the diagnosis of nature of pathological lesions. When angiography could be performed by stereo-magnification radiography, the radiography gives better information for physicians. In this article, we tried angiography by the stereomagnifying radiography system utilizing X-TV equipment for examination of digestive system. 1. To magnify film image, the film changer was modified to move up and down, because the board of TV table did not change vertically. The board of TV table was also modified to slide more widely. The modifications could make it possible to magnify the film image by two times. 2. To use the X-TV equipment brought some advantages as follows it became very easy for us to convert the X-TV system from fluoroscopy to radiography, and contact seriography was easily changed to stereo-magnification seriography.
Keywords 立体拡大撮影 (Stereo-magnification radiography) フィルム連続撮影装置 (Fiim changer) 立体感 (Stereoscopic image)
Publication Title 環境病態研報告
Published Date 1986-07
Volume volume57
Start Page 61
End Page 66
ISSN 09133771
language 日本語
File Version publisher
NAID 120002309165
JaLCDOI 10.18926/19693
Title Alternative Angiography system combined with Toshiba BV type X-TV equipment. 1. Whole limb serial aort-arteriography
FullText URL 057_056_060.pdf
Author Nakai, Mutsuo| Akiyama, Tsuneo| Matsushima, Kishio|
Abstract 消化管診断用X線TV装置の天板機能を改良し,種々のフィルムチェンジャー,X線管球を組み合わせることにより,中規模病院において,スペース,経費などの点で有利な,血管造影システムを組むことができた。第1報では,このうち,下肢連続撮影システムについて紹介する。1.透視から造影まで,迅速に移行できるシステムとなった。2.スペース,経費の点で有利である。3.濃度補償については,LS-Ⅱ増感紙と,1.0cmエッジフィルターにより,体型によらず,全下肢にわたり,十分な補償効果が得られる。4.さらに長い長尺カセッテの開発が望まれる。
Abstract Alternative A whole-limb serial aort-arteriography system constituted of BV-type X-TV and extralarge film changer was developed and used clinically. The results were as foll-ows. 1. By improving functions of the board of TV table, changes from fluoroscopy to radiography became easier in whole limb serial aort-arteriography. 2. By using LS-Ⅱ screen and 1.0cm edge filter, we could get well compensated X-ray photographs.
Keywords 全下肢連続動脈造影 (whole-limb serial aort-arteriography) 長尺フィルムチェンジャー (extra-large-film changer) X-TV台天板 (the board of TV table)  濃度補償 (compensation of density)
Publication Title 環境病態研報告
Published Date 1986-07
Volume volume57
Start Page 56
End Page 60
ISSN 09133771
Related Url http://eprints.lib.okayama-u.ac.jp/19952
language 日本語
File Version publisher
NAID 120002308997
JaLCDOI 10.18926/19687
Title Alternative Studies on sinter deposits of misasa radioactive hot springs (3RD report)
FullText URL 057_046_055.pdf
Author Mifune, Masaaki| Seno, Toshinobu|
Abstract 鳥取県三朝温泉岡大源泉の配湯管内の温泉沈殿物について既に報告されているが,今回採取した黒色の温泉沈殿物について発光分析法による定性分析を行ったところ,強放射性鉱物である北投石の主成分のBaが高濃度に検出されたので,岡大源泉(飲泉)水および沈殿物中の主要成分および放射能について調査した。温泉水のpHは6.97,Rn-222濃度は190.9Bq./kgで,Mn,Fe,Baの濃度は夫々0.011,0.018,0.021(mg/kg)であり,泉質は弱放射能-ナトリウム-塩化物泉に該当した。沈殿物中の主要成分はMn,Fe,Baで,その濃度は夫々363.5,148.0,69.6mg/gであり,このBa濃度は三朝温泉の温泉沈殿物中最高の濃度であった。しかしRa-226濃度は,既報程 度の3.30×10(-8)Ci/kgであった。
Abstract Alternative The hot spring waters of Okadaisen and the sinter deposit in the distributing pipe which was used for about 20 years were investigated. The analysis of the spring waters and the sediment were mainly carried out by Spectraspan emission spectrophotometer. Radium-226 in the sinter deposit and radon-222 in the spring waters were measured by vibrating reed electrometer and liquid scintillation counter, respectively. As the results of the analysis, this spring waters were classified into weakly radioactive sodium-chloride waters. It also contained 3.73mg/kg of F and 190.9 Bq./kg of radon-222. The major components of this deposit were characterized with regard to high concentration of Mn (363.5mg/g), Fe (148.0mg/g), and Ba (69.6mg/g). Ra-226 concentration of the sinter deposits of Misasa hot springs in previous reports were 6.24×10(-12)~5.74×10(-8) (Ci/g), but its concentration in this report was 3.30×10(-8) Ci/g. It seems that a linear correlation is recognized between radium-226 and (Fe+Mn) concentrations in the sinter dedosits of Misasa hot springs.
Keywords 三朝温泉 (Misasa hot springs) 温泉沈殿物 (Thermal sinter deposits) バリウム (Barium) ラジウム (Radium) ラドン (Radon)
Publication Title 環境病態研報告
Published Date 1986-07
Volume volume57
Start Page 46
End Page 55
ISSN 09133771
Related Url http://eprints.lib.okayama-u.ac.jp/19952
language 日本語
File Version publisher
NAID 120002309145
JaLCDOI 10.18926/19683
Title Alternative Studies on anti-allergic actions of tranilast (Rizaben®)
FullText URL 057_042_045.pdf
Author Tanizaki, Yoshiro| Komagoe, Haruki| Sudo, Michiyasu| Morinaga, Hiroshi| Ohtani, Jun| Kimura, Ikuro|
Abstract 抗アレルギー剤(脱顆粒抑制剤)の1つであるtranilastの肥満細胞の遊離機序に対する抑制作用について検討を加えた。1.抗原刺激時の肥満細胞の(45)Ca uptakeおよびヒスタミン遊離に対して,tranilastは有意の抑制作用を示したが,comp.48/80刺激時にはtranilastの(45)Ca uptake,ヒスタミン遊離に対する抑制作用はほとんどみられなかった。2.phosphatidylserine添加時には,(45)Ca uptakeに対するtranilastの抑制作用は減弱傾向を示し,この傾向はヒスタミン遊離に対する作用に比べより高度であった。3.抗原および抗ヒトIgEによる好塩基球からのヒスタミン遊離に対して,tranilastは明らかな抑制作用を示さなかった。
Abstract Alternative Tlanilast is clinically used for bronchial asthma as one of the prophylactic agents for asthma attacks. In this study, anti-allergic actions of tranilast were examined in (45)Ca uptake of and histamine release from target cells of IgE after stimulation with antigen, anti-IgE and camp. 48/80. 1. (45)Ca uptake of and histamine release from rat peritoneal mast cells stimulated by antigen were significantly inhibited by preincubation of the cells with tranilast. Inhibition by tranilast of increased (45)Ca uptake of mast cells by addition of phosphatidylserine were less, although inhibition of histamine release was not so affected by addition of phosphatidylserine. No significant inhibition by tranilast of (45)Ca uptake and histamine release was not observed when the cells were stimulated by camp. 48/80. 2. Tranilast showed any inhibitory effects on basophil histamine release induced by antigen and anti-IgE.
Keywords トラニラスト (tranilast) (45)Ca取り込み ((45)Ca uptake) ヒスタミン遊離 (histamine release) 肥満細胞 (mast cell) 好塩基球 (basophils)
Publication Title 環境病態研報告
Published Date 1986-07
Volume volume57
Start Page 42
End Page 45
ISSN 09133771
language 日本語
File Version publisher
NAID 120002308998
JaLCDOI 10.18926/19678
Title Alternative Spa therapy for bronchial asthma. Annual changes of characteristics of asthmatics admitted during the past four years.
FullText URL 057_037_041.pdf
Author Tanizaki, Yoshiro| Sudo, Michiyasu| Komagoe, Haruki| Morinaga, Hiroshi|
Abstract 1982年1月から1985年12月までの4年間に三朝分院内科へ入院し,温泉療法を受けた気管支喘息45例を対象にその年次推移を検討した。1.性別:初期2年間は男性の入院症例が多い状況であったが,後期2年間では男女比はほぼ等しかった。2.年令:年次推移はみられず,その平均年令は50±2才の間にあった。3.地域分布:初期2年間は岡山県からの入院症例が多数をしめたが,後期2年間ではむしろ鳥取県からの入院症例が増加する傾向がみられた。4.入院期間:初期2年間の平均入院期間は6.7カ月,6.5カ月とかなり長くなる傾向がみられたが,後期2年間ではそれぞれ3.0カ月,1.5カ月と明らかな短縮傾向がみられた。5.臨床病型:いずれの年度においても重症化傾向の強いⅠb型,Ⅱ型が多くみられたが,各年度間には差はみられなかった。6.ステロイド剤使用状況:年度の経過とともにその使用量は減少して いく傾向が示された。
Abstract Alternative Annual changes of characteristics, sex, area (Prefecture) of patients' coming from, term of admission, clinical classification of asthma and use of glucocorticoids, were examined in 45 patients with bronchial asthma who were admitted at Misasa Hospital, Okayama University Medical School and received spa therapy during the past four years from 1982 to 1985. In the first two years from 1982 to 1983, more patients with bronchial asthma were admitted from Okayama Prefecture, and the majority of them had severe asthma attacks and were more dependent on steroid-therapy. On the other hand, in the past two years from 1984 to 1985, number of patients with bronchial asthma from Tottori Prefecture increases, and their attacks were less severe and less dependent on steroid-therapy compared to the patients admitted during the first two years. Term of admission became shorter in the past two years than in the first two years. Any differences between the first and the past two years were not shown in sex, patient age and asthma types classified by clinical symptoms.
Keywords 気管支喘息 (Bronchial asthma) 温泉療法 (spa therapy) 臨床病型 (asthma type)
Publication Title 環境病態研報告
Published Date 1986-07
Volume volume57
Start Page 37
End Page 41
ISSN 09133771
language 日本語
File Version publisher
NAID 120002309135
JaLCDOI 10.18926/19669
Title Alternative Diagnosis of chronic pancreatitis
FullText URL 057_029_036.pdf
Author Takeda, Masahiko| Harada, Hideo| Matsumoto, Shuji| Ochi, Koji| Tanaka, Juntaro| Yoshida, Mitsuo| Oka, Hiroo| Miyake, Hirofumi| Kimura, Ikuro|
Abstract 近年,各種膵疾患に対する検査法の発達には目を見張るものがあるが,実際の運用にあたっては各検査法の適応,限界,組合わせおよび実施する順序等に迷うことが少なくない。本研究では,最近我々が経験した慢性膵炎Ⅰ群116例の診断過程を振り返ることにより,慢性膵炎の診断における理想的な検査法の組合わせとそれぞれの役割を検討し,同時に診断名のみならず病態と病期が容易に理解できる表現方法を提案した。画像診断法,膵外分泌機能検査法(EX),膵内分泌機能検査法(EN)を比較検討し,以下の結果を得た。①画像診断法は必須である。②内視鏡的逆行性膵胆管造影(ERCP)を軸とした腹部超音波検査(US)あるいは腹部CTスキャン(CT)の組合わせは欠くことができない。③EXもまた必須の検査法である。④ENは慢性膵炎の診断に必要不可欠ではないが,治療方針を決めるうえで重要である。⑤純粋膵液(PPJ)の生化学的検査と組織化学的検査は膵炎の診断と病態生理の解明に重要である。⑥PPJ中の細胞診は慢性膵炎に合併した膵癌の検索に有用である。⑦以下に示すような診断の記載方法を提案した。"Calcified chronic pancreatitis, alcoholic, diffuse, ERCP-3, US-2, CT-3, EX-2, EN-1, Lf(+)"。
Abstract Alternative Endoscopic retrograde cholangiopancreatography (ERCP), ultrasonography (US), computed tomography (CT), exocrine pancreatic function test (EX), endocrine pancreatic function test (EN), and analysis of pure pancreatic juice (PPJ) are currently available for the investigation of pancreatic diseases. The purpose of the present study is to evaluate the roles and preferable combinations of these tests in the diagnosis of chronic pancreatitis and then to propose a way to describe the results of the tests along with diagnosis for a better understanding of the disease process. Comparative studies of imaging, EX and EN led to the following conclusions. 1) imaging procedures (ERCP, US and CT) are mandatory, partly because they were frequently the test that showed diagnostic changes and partly because they often gave key information for operative treatment. Among the imaging procedures, ERCP combined with US and/or CT is mandatory because these combinations alone can reveal detailes of structural changes attendant on chronic pancreatitis. 2) EX is also mandatory, because it was occasionally the only test that showed diagnostic changes and partly because it often gave important information for medical treatment. 3) EN is also important, not because it was indispensable for detecting chronic pancreatitis, but because it often gave important information for medical treatment. For btter understanding of the disease process as well as diagnosis, we propose, as suggested by Seligson, that the test used for the establishment of the diagnosis and the degree as well as extent of abnormalities. An example is "Calcified chronic pancreatitis, alcoholic, diffuse, ERCP-3, US-2, CT-3, EX-2, EN-1, Lf(+)". This attitude will lead to a more rational approach to both diagnosis and treatment.
Keywords 慢性膵炎 (chronic pancreatitis) 画像診断 (imaging diagnosis) PS試験 (pure pancreatic juice) 純粋膵液(PPJ) (Pancreozymin-Secretin test) 内視鏡的逆行性膵胆管造影(ERCP) (endoscopic retrograde cholangiopancreatography (ERCP))
Publication Title 環境病態研報告
Published Date 1986-07
Volume volume57
Start Page 29
End Page 36
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002309023
JaLCDOI 10.18926/19662
Title Alternative Effect of aging on pancreatic exocrine function -Aging and fecal chymotrypsin activity-
FullText URL 057_024_028.pdf
Author Matsumoto, Shuji| Harada, Hideo| Ochi, Koji| Takeda, Masahiko| Tanaka, Juntaro| Morinaga, Hiroshi| Yoshida, Mitsuo| Kimura, Ikuro|
Abstract 膵外分泌機能に及ぼす加齢の影響を検討する目的で,健常人43名,非膵疾患患者41名,老人ホーム入居者39名を対象として比色法により糞便中キモトリプシン活性(FCA)を測定し,以下の結論を得た。1)FCAは逐齢的に低下し,60歳以上は60歳未満より有意の低値を示した。しかし,分布図のretrospectiveな検討からは,膵外分泌機能の低下は,実際には65~70歳あたりから明らかになることが示唆された。2)FCAの正常下限値を14.5U/gに定めたが,高齢者の診療にあたってはこの正常値のみを根拠にして疾病の有無を判定すべきではない。3)老人ホーム入居者のFCAは特に低値を取ったがその主要因は高齢者が多いためと考えられた。
Abstract Alternative To examine the effect of aging on the pancreatic exocrine function, fecal chymotrypsin activity (FCA) was measured by the photometric method in 43 healthy controls, 39 controls in an old-age home and 41 patients with non-pancreatic diseases. Following conclusions were obtained. 1) Pancreatic exocrine function showed a significant decrease with aging as indicated by the present prospective study : ① a significantly lower FCA in the B group of 22 healthy controls (≧ 60 years of age) than the A group of 21 healthy controls (< 60 years of ago) ; ② significant correlationship between aging and FCA in the 43 healthy controls and also in the 41 patients with non-pancreatic diseases. 2) FCA in controls in an old-age home was especially low. Presumably it was due to their far-advanced aging. 3) The calculated lower limit of normal in FCA was 14.5U/g. However, the diagnosis of pancreatic diseases should not be coined solely on the basis of decreased FCA value.
Keywords 糞便中キモトリプシン活性 (Fecal chymotrypsin activity) 加齢 (Aging) 膵外分泌機能 (Pancreatic exocrine function) 膵 (Pancreas) 酵素 (Enzyme)
Publication Title 環境病態研報告
Published Date 1986-07
Volume volume57
Start Page 24
End Page 28
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002309096
JaLCDOI 10.18926/19656
Title Alternative An application of artificial CO(2)-bathing for psychosomatic disorders in childhood
Author Komoto, Junko|
Abstract 人工炭酸浴剤浴(パブ浴)は,末梢循環改善作用を有して組織に賦活力を与え,皮膚創傷治癒を促進させる。全身に引き掻き傷を有する心身症の少女2症例に対して,母親とともにパブ浴を常用させた。何れの症例においても,皮膚創傷治癒をみて,患児,および母親に治療者を頼ってみようという,いわば治療への動機づけが促がされ,入浴という手段で児童の最大のストレスである母子関係の阻害に対し脱ストレス的に働き患児とのラポールがえられるようになった。パブ浴には副作用は全くなく,児童期の様々な心身症に応用されてよいであろう。
Abstract Alternative The artificial CO(2)-bathing was prescribed for two girls with psychosomatic disorders. Case 1 was diagnosed as anorexia nervosa with self-injured wounds in the face and extremlties. Case 2 was diagnosed as trichotillomania with self-injured wounds in the whole body. A tablet of 50g, made from sodium bicarbonate and succinic acid, was put in a bathtub of 150-200 litres at 40℃. Each patient was recommended to take a bath with her mother longer than at least 10 minutes. Both two cases became free from selfinjured wounds in about one week after the initiation of the artificial CO(2)-bathing, and gradually began to show positive 'Rapport' to the therapist. Underlying psychopathology and family dynamics were worked through the therapeutic sessions following the artificial CO(2)-bathing. It was suspected that the healing effect for wounds together with the relaxing effect for difficulty in interpersonal relationship with CO(2)-bathing, as a playful bubble bathing, resulted in successful outcome or both two cases.
Keywords 人工炭酸浴 (Artitificial CO(2) bathing) 自傷 (seif-injured wounds) 創傷治癒効果 (healing effect for wounds) 母子関係改善 (relaxing effect for mother-child relationship) あそび的効果 (play-therapeutic effect)
Publication Title 環境病態研報告
Published Date 1986-07
Volume volume57
Start Page 18
End Page 23
ISSN 09133771
language 日本語
File Version publisher
JaLCDOI 10.18926/19651
Title Alternative Clinical trials with artificial CO(2) bathings
FullText URL 057_012_017.pdf
Author Usui, Yasuko| Komoto, Junko| Sunakawa, Mitsuru| Kohmoto, Tomoji| Komoto, Yoshiaki|
Abstract パブ浴(人工炭酸浴剤浴)は,組織に酸素を供給し,また組織循環の改善により組織に賦活力を与え,さらに末梢毛細血管の拡張作用を有する。外来患者を対象に,末梢循環障害5例,高血圧症2例,不定愁訴症例2例を選び,半年より1年にわたって家庭でパブ浴を連浴させた。全例に,併用薬の減量,あるいは中止をみた。とくに蛋白尿を伴った高血圧症例では,血圧の正常化に伴って蛋白尿の減少をみた。炭酸泉の効果は連浴によっても変化を認めず,人工炭酸泉浴は家庭においても療養泉としての効果がえられ,疾病の自然予後に有為に作用する。
Abstract Alternative Clinical trials for 5 cases of peripheral circulation insufficiency, 2 cases of hypertension, 2 cases of general malaise and 2 cases of liver function insufficiency were performed with artificial CO(2) baths using BUB-KAO, a 50 g sodium hydogencarbonate and succinic acid tablet, KAO Co. Ltd., Japan, in 150-litre-tub at 40℃ for 10-20 minutes in a period of 6 to 12 months. By virtue of an increase of tissue PO(2) and an improvement of tissue perfusion with artificial CO(2) baths, favorable effects were obtained in all cases but in 2 patients with liver function insufficiency, leading to reduce or discontinue the regular medications. Remarkable effect was observed in 2 cases of hypertension, being brought under control in 2 months, keeping normal range thereafter due possibly to lowering the peripheral resistance caused by capillary dilation effect. A greate favor of hypotensive effect was granted in reducing the excretion of urinary protein. It is very advantageous in maintaining homeostasis to ameliorate natural course of diseases with artificial C (2) baths which are effective by repeated routine use for a long period of time, leading to assist modern way of medical treatment.
Keywords 人工炭酸泉浴 (Artificial CO(2) bath) 連浴 (serial bathing) 末梢循環障害 (peripheral circulation insufficiency) 高血圧症 (hypertension) 不定愁訴 (general malaise)
Publication Title 環境病態研報告
Published Date 1986-07
Volume volume57
Start Page 12
End Page 17
ISSN 09133771
language 日本語
File Version publisher
NAID 120002309069
JaLCDOI 10.18926/19647
Title Alternative Screening test for chromosome aberrations of long-time residents in misasa spa.
FullText URL 057_009_011.pdf
Author Komoto, Yoshiaki| Kohmoto, Tomoji| Sunakawa, Mitsuru| Yagi, Nobuko| Mifune, Masaaki|
Abstract 三朝温泉のラドン含有は,源泉で約1347~2694Bq/l,常用温泉水で137~224Bq/l,また,屋内では7.3~73.7Bq/lである。三朝温泉地に出生して,28~75年にわたる入浴者9名,および三朝温泉地外に出生して16~78 年にわたる入浴者4名について末梢静脈血の染色体検査を,ギムザ染色,および特に長年入浴している3名についてはG一分染法による分析を行なった。浴水,および生活環境のラドン濃度の多寡によらず,長年の入浴によっても染色体の構造変化は正常範囲内であった。
Abstract Alternative Screening test for chromosome aberrations of 13 long time residents, 9 native and 4 movingin in Misasa Spa was performed. Each Radon content in baths ranges 166-224 Bq/l, in homes 8.6-73.7 Bq/l, and in offices 8.4-22 Bq/l. Normal Karyotypes on both sexes and normal range of aberrations, gaps and breaks, were found in chromosome analyses. There are no significant radioactive effects from longtime bathings and from environment in both groups of Misasa spa districts, corresponding to the facts of no significant incidence of infertility, malformations, a brief span of life, and neoplasms compared to other places.
Keywords 三朝温泉地 (Misasa spa) ラドン泉 (Radon bath) 染色体異常 (Chromosome aberration)
Publication Title 環境病態研報告
Published Date 1986-07
Volume volume57
Start Page 9
End Page 11
ISSN 09133771
language 日本語
File Version publisher
NAID 120002309001
JaLCDOI 10.18926/19630
Title Alternative The effect of artificial CO(2) bathing on peripheral circulation insufficiency.
FullText URL 057_003_008.pdf
Author Komoto, Yoshiaki| Kohmoto, Tomoji| Sunakawa, Mitsuru| Yorozu, Hidenori| Eguchi, Yasuteru|
Abstract 末梢動脈の慢性閉塞性疾患に対する血行再建術の予後は不良で,虚血肢の治療には一定の見解が乏しく非常に難澁するものである。組織循環の概念にもとづいた評価法によると,医用質量分析装置を用いた虚血肢運動負荷後のPtCO(2)の脱飽和曲線の型により組織循環の良否が定まる。組織循環の良好な型では,自然予後は良好で,いかなる保存的治療にもよく反応する。一方,組織循環の不良な型の自然予後は不良であるので,人工炭酸泉浴によるPtO(2)の増加,および組織循環量の改善により予後は良好となる。人工炭酸泉浴は,組織循環の良好な症例には治癒促進的に作用し,組織循環の不良な症例にも有効に作用する。
Abstract Alternative Arteriography provides clear and useful information of ischemic leg anatomy. The method is limited, in that measurement of less than 100μ can not be made. The hemodynamics or functional consequences of the ischemic state should be evaluated by tissue circulation or perfusion methods that depend principally on systemic blood flow. Tissue perfusion is classified in two groups, insufficient and sufficient, depending on the type of clearance curve of PCO(2) in leg muscle following ankle exercise by means of medical mass spectrometry, Medspect Ⅱ, Chemetron, U.S.A. Either artificial CO(2) bathing or CO(2) vapour bath are efficacious for peripheral ischemic wound. Artificial CO(2) bathing is prepared with BUB-KAO 2tab., a 50g sodium hydrogen-carbonate and succinic acid tablet, Kao Co. Ltd. Japan, in 280-litre-tub at 40℃ for 20 minutes. CO(2) vapour bath is prepared with UKS CO(2) Trockengas Badkabine, Hansen Co., Ltd. West Germany, 20-litre-CO(2) per minutes at 40~42℃ for 20 minutes. In the case of insufficient tissue perfusion, ischemic wound is met promising outcome with CO(2) bathing even though no hope is expected with any medicine for peripheral circulation. Whereas, in the case of sufficient tissue perfusion, ischemic wound is expected much help of CO(2) bathing, as well as of all kinds of medicine, in healing process.
Keywords 人工炭酸浴 (Artificial CO(2) bath) 連浴 (serial bathing) 末梢循環障害 (peripheral circuiation insufficiency) 医用質量分析装置 (medical mass spectrometer) 組織循環 (tissue perfusion)
Publication Title 環境病態研報告
Published Date 1986-07
Volume volume57
Start Page 3
End Page 8
ISSN 09133771
language 日本語
File Version publisher
Author 三朝分院看護部|
Published Date 1991-08
Publication Title 環境病態研報告
Volume volume62
Content Type Others
Author Takuma, Masae| Masui, Etsuko| Hayashimoto, Kanae| Asaumi, Noboru| Tachibana, Hideo| Ochi, Koji| Harada, Hideo|
Published Date 1991-08
Publication Title 環境病態研報告
Volume volume62
Content Type Others
JaLCDOI 10.18926/15167
Title Alternative A case of rheumatoid arthritis with hypoproteinemia probably induced by diseasemodifying antirheumatic drug, D-Penicillamine
FullText URL 062_080_083.pdf
Author Kitani, Hikaru| Mitsunobu, Fumihiro| Mifune, Takashi| Okazaki, Morihiro| Tanizaki, Yoshiro|
Abstract 症例は52歳女性で,慢性関節リウマチ(RA)はclassical,stageIV, class 2であった。症状は進行性で加療を行うも改善がみられなかった。平成元年11月RA症状の増悪のための再入院後,Penicillamine 100~200 mg,Sulfasalazine 500mgを合せて投与を行ったところ,血沈,CRP等の検査所見は改善傾向を示したが入院時には正常値であった血清蛋白量がその後5.1g/dlまで低下し,下肢浮腫が出現,その後さらに血清蛋白量は4.1g/dlにまで減少した。治療により蛋白量は5.8g/dlにまで回復したが,低蛋白血症の原因としてはD-Penicillamineの関与が疑われた。
Abstract Alternative A patient with classical rheumatoid arthritis was treated with D-Penicillamine and other drugs. In the course of treatment, the episodes of hypoproteinemia were found twice. The first hypoproteinemia was improved almostly by supportive therapy and withdrawl of administration of medicines, including D-Penicillamine. The second hypoproteinemia was severe and resistant to the treatment. It was suggested that the agent eliciting hypoproteinemia in this case might be D-Penicillamine.
Keywords 慢性関節リウマチ (Rheumatoid arthritis) 低蛋白血症 (Hypoproteinemia) D-ペニシラミン (D-Penicittamine) 抗リウマチ剤 (Disease-modifying antirheumatic drug)
Publication Title 環境病態研報告
Published Date 1991-08
Volume volume62
Start Page 80
End Page 83
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002307840
JaLCDOI 10.18926/15097
Title Alternative Possible participation of viral infection in the onset mechanisms of bronchial asthma
FullText URL 062_076_079.pdf
Author Mifune, Takashi| Mitunobu, Fumihiro| Okazaki, Morihiro| Kitani, Hikaru| Tanizaki, Yoshiro|
Abstract ウイルスなどの気道感染により,気管支喘息症状が発症したり,あるいは増悪したりすることが知られている。自験例は65歳の女性で,上気道炎症状に引き続いて,気管支喘息が発症した。臨床症状の軽快とともに気道過敏性・IgE値は低下し,感染による気道過敏性の亢進,IgE型アレルギー反応の機序が関与していると考えられた。これらの結果は喘息患者は気道感染(特にウイルス感染)の予防が必要であり,感染した場合には抗喘息剤とともに抗炎症剤の使用が有用である可能性を示している。
Abstract Alternative It is well known that respiratory infection induces asthma attacks. In this paper one case showing possible participation of viral infection in the onset mechanisms of bronchial asthma was reported. A 65-year-old woman was admitted to Misasa Hospital because of moderate asthma attacks. The attacks appeared after upper respiratory infection. Bronchial hyperactivity were increased when she admitted at the hospital, and decreased with the improvement of the asthma symptoms. It is suggested from her clinical course that repiratory infection (especially by virus) may affect the bronchial hyperactivity and IgE synthesis.
Keywords 気道感染 (Respiratory infection, Virus infection) 気道過敏性 (Bronchial hypersensitivity) lgEアレルギー反応 (Allergic reaction mediated by IgE)
Publication Title 環境病態研報告
Published Date 1991-08
Volume volume62
Start Page 76
End Page 79
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002307679
JaLCDOI 10.18926/15065
Title Alternative The biochemical and biological activities of JUN.
FullText URL 062_071_075.pdf
Author Mitsunobu, Fumihiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Asaumi, Noboru| Tanizaki, Yoshiro|
Abstract c-junはニワトリの癌ウイルスから分離された癌遺伝子(v-jun)のproto-oncogeneであり,その遺伝子産物は細胞内転写促進因子AP-1の主成分である。v-jun,c-junのトランスフォーム能を検討するために,我々はv-jun,ニワトリc-jun遺伝子さらにJUN遺伝子の種々の組換え体を複製能を持つレトロウイルスベクター(RCAS)に挿入し,CEF細胞(ニワトリ胎児線維芽細胞)にトランスフェクションした。その結果4か所存在する両者の構造的相違のうち,アミノ末端近くの27アミノ酸の欠損と3' untranslated regionの欠損が十分なトランスフォーム能と転写促進能発現に必須であることが明らかとなった。これらの部分がどのように機能発現に関与しているかは,これからの研究を待たねばならない。
Abstract Alternative V-jun is the oncogene which was isolated from the avian transforming virus ASV17. C-jun is the proto-oncogene of v-jun. The product of the proto-oncogene, c-jun, is a major component of the AP-1 transcription complex. AP-1 regulates the transcription of several genes through its ability to bind specifically to the sequence TGACTCA and variations of this motif. In order to assess the transforming capability of c-jun protein, we have introduced v-jun, the chicken c-jun proto-oncogene and several mutants into a replication competent avian retroviral expression vector (RCAS). Each of those was expressed in CEF and assayed for transformation by focus formation. Analysis of the results reveals that deletion of a region of 27 amino acids near the amino terminus of c-jun and deletion of 3' untranslated sequences are critical in activating the full oncogenic potential of jun.
Keywords 癌遺伝子 (Oncogene) JUN遺伝子 (JUN gene) レトロウイルスベクター (Retrovirus Vector) トランスフェクション (Transfection) トランスフォーム (Transform)
Publication Title 環境病態研報告
Published Date 1991-08
Volume volume62
Start Page 71
End Page 75
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002307874
JaLCDOI 10.18926/15041
Title Alternative Alcohol-induced pancreatitis
FullText URL 062_052_070.pdf
Author Harada, Hideo| Tanaka, Juntaro| Ochi, Koji| Matsumoto, Shuji| Seno, Toshinobu| lzushi, Michihiro| Tanizaki, Yoshiro|
Abstract 膵炎のうちもっとも頻度が高いアルコール性膵炎(AIP)の疫学,臨床像および発生機序に関する従来の知見を総括した。AIPの大多数は慢性膵炎である。通常は長期にわたる多量の飲酒を背景に発症するが,遺伝的素因および食事因子も重要な役割を演じる。発症初期には血中膵酵素の上昇をともなう腹痛が病像を支配するが,進展すると膵外分泌不全による消化吸収障害と膵内分泌不全による糖尿病が病像を支配するようになる。アルコール性慢性膵炎は非アルコール性慢性膵炎にくらべて確診時にすでに進展した症例が多く,合併症が多く,進行が早く,予後が悪い。死亡の主たる原因は癌の併発と糖尿病の合併症で,膵炎の急性増悪発作がこれにつぐ。併発する癌のなかでは膵癌よりもむしろ上部気道および上部消化管の癌が多い。発生機序としてはDuctal-Plug説とToxic-Metabolic説が有力であるが,最近は細 胞内膵酵素活性化説とFree Radical説も注目をあびている。
Abstract Alternative This paper is to review the literature on the epidemiology, clinical pictures and etiopathogenesis of alcohol-induced pancreatitis (AIP). The incidence of AIP has been increasing worldwide, paralleling the increase in alcohol consumption. AIP manifests itself following a longterm consumption of large amounts of alcohol. There is no known threshold value of alcohol consumption in terms of the risk of developing AIP, although the logarithm of the risk of developing AIP is lineally correlated with the amount of alcohol intake. Why some alcoholics develop pancreatitis whereas others with equal consumption of ethanol are spared remains to be explained. Therefore, two additional factors are considered to play important roles in developing AIP : genetic predisposition and diet. The majority of AIP IS chronic pancreatitis (AICP), although a minority can be acute pancreatitis (AIAP). AIAP shows somewhat higher morbidity and mortality than the common variety of acute pancreatitis. If recovered from an attack, AIAP shows morphological and functional restoration. AICP manifests itself with an acute attack of abdominal pain, insidious onset of abdominal pam, or a pain-free variety. An acute attack in AICP resemble that m AIAP ; often these two can be differentiated only by follow-up studies. AICP shows no morphological and functional restoration, and often shows progressive deterioration. Abdominal pain with elevated serum pancreatic enzymes is a predominant clinical picture m the early stage of AICP, whereas in the late stage symptoms and signs deriving from exocrine insufficiency (maldigestion) and endocrine insufficiency (pancreatic diabetes) begin to dominate the clinical pictures. AICP is in the more advanced stage and shows more complications than nonalcoholic chronic pancreatitis at the time of diagnosis. In addition, AICP shows more rapid progress and higher morbidity and mortality. The incidence of microangiopathy in pancreatic diabetes resemble that in primary diabetes, being higher in patients with a longer history of diabetes, those on insulin treatment and those under poorer control. Main causes of death are development of cancer in the upper respiratory and gastrointestinal tract and diabetic complications (hypoglycemic shock, renal failure, and intractable pneumonia), and acute attack of pancreatitis leads to death less frequently. Ductal-Plug theory and classical Toxic-Metabolic theory are most popular to explain the pathogenesis of AIP ; however, increasing evidence has been reported that oxygen free radicals and intracellular activation of zymogens by lysosomal enzymes may be involved in the pathogenesis.
Keywords アルコール性膵炎 (Alcohol-induced pancreatitis) 慢性膵炎 急性膵炎
Publication Title 環境病態研報告
Published Date 1991-08
Volume volume62
Start Page 52
End Page 70
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002307918