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ID 46963
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Author
Yorimitsu, Takeshi
Kiritooshi, Naruto
Abstract
A pair of the Drosophila eye-antennal disc gives rise to four distinct organs (eyes, antennae, maxillary palps, and ocelli) and surrounding head cuticle. Developmental processes of this imaginal disc provide an excellent model system to study the mechanism of regional specification and subsequent organogenesis. The dorsal head capsule (vertex) of adult Drosophila is divided into three morphologically distinct subdomains: ocellar, frons, and orbital. The homeobox gene orthodenticle (otd) is required for head vertex development, and mutations that reduce or abolish ad expression in the vertex primordium lead to ocelliless flies. The homeodomain-containing transcriptional repressor Engrailed (En) is also involved in ocellar specification, and the En expression is completely lost in otd mutants. However, the molecular mechanism of ocellar specification remains elusive. Here, we provide evidence that the homeobox gene defective proventriculus (dye) is a downstream effector of Otd, and also that the repressor activity of Dye is required for en activation through a relief-of-repression mechanism. Furthermore, the Dye activity is involved in repression of the frons identity in an incoherent feedforward loop of Otd and Dye.
Keywords
Drosophila
Eye
Orthodenticle
Hedgehog
Engrailed
Iroquois
Published Date
2011-08-15
Publication Title
Developmental Biology
Volume
volume356
Issue
issue2
Publisher
Academic Press Inc. Elsevier Science
Start Page
598
End Page
607
ISSN
0012-1606
NCID
AA00627848
Content Type
Journal Article
language
英語
Copyright Holders
© 2011 Elsevier Inc. All rights reserved.
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author
Refereed
True
DOI
PubMed ID
Web of Science KeyUT