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ID 57456
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Sumi, Tomonari Research Institute for Interdisciplinary Science, Department of Chemistry, Faculty of Science, Okayama University ORCID Kaken ID publons researchmap
Klumpp, Stefan Department Theory and Bio-Systems, Max Planck Institute of Colloids and Interfaces
Abstract
We present a chemomechanical network model of the rotary molecular motor F1-ATPase which quantitatively describes not only the rotary motor dynamics driven by ATP hydrolysis but also the ATP synthesis caused by forced reverse rotations. We observe a high reversibility of F1-ATPase, that is, the main cycle of ATP synthesis corresponds to the reversal of the main cycle in the hydrolysis-driven motor rotation. However, our quantitative analysis indicates that torque-induced mechanical slip without chemomechanical coupling occurs under high external torque and reduces the maximal efficiency of the free energy transduction to 40–80% below the optimal efficiency. Heat irreversibly dissipates not only through the viscous friction of the probe but also directly from the motor due to torque-induced mechanical slip. Such irreversible heat dissipation is a crucial limitation for achieving a 100% free-energy transduction efficiency with biological nanomachines because biomolecules are easily deformed by external torque.
Keywords
F-1-ATPase
rotary molecular motor
chemomechanical network model
free-energy transduction efficiency
ATP synthesis
torque-induced mechanical slip
Published Date
2019-04-24
Publication Title
Nano Letters
Volume
volume19
Issue
issue5
Publisher
American Chemical Society
Start Page
3370
End Page
3378
ISSN
15306984
NCID
AA11511812
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
Copyright Holders
Copyright © 2019 American Chemical Society
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Web of Science KeyUT
Related Url
isVersionOf https://doi.org/10.1021/acs.nanolett.9b01181
Funder Name
Japan Society for the Promotion of Science
助成番号
18KK0151 : Understanding solvent-mediated forces with diverse responses to ions, co-solvents, and temperature