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ID 58256
Author
Araki, Yuya Division of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University
Miyoshi, Natsumi Division of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University
Morimoto, Kazuki Division of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University
Kudoh, Takayuki Division of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University Kaken ID publons researchmap
Mizoguchi, Haruki Division of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University ORCID Kaken ID
Sakakura, Akira Division of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University ORCID Kaken ID publons researchmap
Abstract
A formal total synthesis of manzacidin B is described. beta,beta-Disubstituted gamma-hydroxy-beta-aminoalcohol, the key structure of manzacidin B, is stereoselectively constructed via sequential Henry reactions. By taking advantage of noncovalent interactions, such as intramolecular hydrogen bonding and chelation, we could diastereodivergently control the stereoselectivity of the Henry reaction.
Published Date
2019-12-18
Publication Title
Journal of Organic Chemistry
Volume
volume85
Issue
issue2
Publisher
American Chemical Society
Start Page
798
End Page
805
ISSN
0022-3263
NCID
AA00704100
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
File Version
author
PubMed ID
DOI
Web of Science KeyUT
Related Url
isVersionOf https://doi.org/10.1021/acs.joc.9b02811
License
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
Citation
J. Org. Chem. 2020, 85, 2, 798-805 Publication Date:December 18, 2019 https://doi.org/10.1021/acs.joc.9b02811
Funder Name
Japan Society for the Promotion of Science
助成番号
18K0S123