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ID 44363
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Author
Hattori, Takafumi
Takayama, Daisuke
Yamamoto, Hiroshi
Abstract
1',2'-Di-O-acetyl-N2-(N,N-dimethylaminomethylene)-3-[2-(4-nitrophenyl)ethyl]neopterin (1) was prepared from neopterin in 5 steps. Glycosylation of 1 with methyl 2,3,4-tri-O-benzoyl-α-D-glucopyranosyluronate bromide in the presence of silver triflate and tetramethylurea afforded the corresponding 3'-O-(methyl β-D-glucopyranosyluronate) neopterin derivative (2) in 64% yield. The first synthesis of 3'-O-(β-D-glucopyranosyluronic acid)neopterin was achieved by successive removal (4 steps) of the protecting groups of 2.
Keywords
neopterin glycoside
D-glucronic acid
glycosylation
protecting groups
Published Date
2010-09
Publication Title
Pteridines
Volume
volume21
Issue
issue3
Publisher
International Society of Pteridinology
Start Page
79
End Page
83
ISSN
0933-4807
Content Type
Journal Article
Official Url
http://www.pteridines.sk/center.php?act=V&volId=140
language
英語
Copyright Holders
Copyright © International Society of Pteridinology
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publisher
Refereed
True
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