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Tokuchi, Ryo Department of Neurology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
Hishikawa, Nozomi Department of Neurology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
Matsuzono, Kosuke Department of Neurology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
Takao, Yoshiki Department of Neurology, Kurashiki Heisei Hospital
Wakutani, Yosuke Department of Neurology, Kurashiki Heisei Hospital
Sato, Kota Department of Neurology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
Kono, Syoichiro Department of Neurology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
Ohta, Yasuyuki Department of Neurology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
Deguchi, Kentaro Department of Neurology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
Yamashita, Toru Department of Neurology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
Abe, Koji Department of Neurology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
Abstract
AIM: The aim of the present study was to compare the effects of a galantamine only therapy and a combination therapy with galantamine plus ambulatory cognitive rehabilitation for Alzheimer's disease patients. METHODS: For this retrospective cohort study, we enrolled 86 patients with Alzheimer's disease, dividing them into two groups - a galantamine only group (group G, n = 45) and a combination with galantamine plus ambulatory rehabilitation group (group G + R, n = 41). The present cognitive rehabilitation included a set of physical therapy, occupational therapy and speech therapy for 1-2 h once or twice a week. We compared the Mini-Mental State Examination and Frontal Assessment Battery for cognitive assessment, and Geriatric Depression Scale, Apathy Scale, and Abe's Behavioral and Psychological Symptoms of Dementia score for affective assessment in two groups over 6 months. RESULTS: The baseline Mini-Mental State Examination score was 20.2 and 18.7 in groups G and G + R, respectively. Other baseline data (Frontal Assessment Battery, Geriatric Depression Scale, Apathy Scale, and Abe's Behavioral and Psychological Symptoms of Dementia) were not different between the two groups. Although group G kept all the scores stable until 6 months of the treatment, the Apathy Scale score showed a significant improvement in group G + R as early as 3 months, followed by the Mini-Mental State Examination and Frontal Assessment Battery improvements at 6 months (*P = 0.04 and *P = 0.02, respectively). The Geriatric Depression Scale and Abe's Behavioral and Psychological Symptoms of Dementia did not show any changes. CONCLUSION: The combination therapy of galantamine plus ambulatory cognitive rehabilitation showed a superior benefit both on cognitive and affective functions than galantamine only therapy in Alzheimer's disease patients.
Keywords
Alzheimer's disease
affective function
cognitive function
combination therapy
galantamine
Note
This is an Accepted Manuscript of an article published by Wiley
Published Date
2016-04
Publication Title
Geriatrics & Gerontology International
Volume
volume16
Issue
issue4
Publisher
Japan Geriatrics Society
Start Page
440
End Page
445
ISSN
1444-1586
NCID
AA1155729X
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
Copyright Holders
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
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isVersionOf https://doi.org/10.1111/ggi.12488