start-ver=1.4 cd-journal=joma no-vol=171 cd-vols= no-issue= article-no= start-page=515 end-page=522 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190812 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Homodinuclear lanthanoid(III) dithiocarbamato complexes bridged by 2,2-bipyrimidine: Syntheses, structures and spectroscopic properties en-subtitle= kn-subtitle= en-abstract= kn-abstract= Four new homodinuclear lanthanoid(III) dithiocarbamato (RR'dtc(-)) complexes bridged by 2,2'-bipyrimidine (bpm) of the form [{Ln(RR'dtc)(3)}(2)(mu-bpm)] {Ln = Nd or Eu; RR' = dimethyl- (Me-2) or pyrrolidine(pyr)} were prepared and their crystal structures and spectroscopic properties were characterized. The crystallographic studies revealed that all of the complexes possess a similar structural motif with an 8:8-coordination geometry, in which the bpm ligand bridges two Ln(III) centers in the kappa N-2(1,1') : kappa N-2(3,3') mode and three RR'dtc(-) ligands coordinate to each Ln(III) center. The complexes exhibit weak but relatively sharp f-f transition bands in the absorption and magnetic circular dichroism (MCD) spectra recorded in the visible region. The MCD spectral studies demonstrated the magneto-optical behavior of the complexes. The spectral features of the dithiocarbamato complexes were distinctly different from those of their beta-diketonato analogues, suggesting the coordination environment around the Ln(III) center influences the electronic structure and spectroscopic symmetry of the complexes in solution. en-copyright= kn-copyright= en-aut-name=YakubuAbdallah en-aut-sei=Yakubu en-aut-mei=Abdallah kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SuzukiTakayoshi en-aut-sei=Suzuki en-aut-mei=Takayoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KitaMasakazu en-aut-sei=Kita en-aut-mei=Masakazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= affil-num=3 en-affil=Faculty of Education, Okayama University kn-affil= en-keyword=2,2 '-Bipyrimidine kn-keyword=2,2 '-Bipyrimidine en-keyword=Dithiocarbamate kn-keyword=Dithiocarbamate en-keyword=Homodinuclear kn-keyword=Homodinuclear en-keyword=Electronic structure kn-keyword=Electronic structure en-keyword=Magnetic circular dichroism kn-keyword=Magnetic circular dichroism END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue=24 article-no= start-page=1562 end-page=1565 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190613 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Efficient and practical synthesis of N-acetyl enamides from ketoximes by unique iron catalytic system en-subtitle= kn-subtitle= en-abstract= kn-abstract= A new procedure for the iron-catalyzed synthesis of enamides from ketoximes was developed, and its mechanism was proposed. A unique reduction system, with the concerted use of KI and Na2S2O4, was involved. The reaction exhibited a wide substrate scope and gave good yields in a short reaction time. The procedure is operationally simple and also applicable for the large-scale synthesis. en-copyright= kn-copyright= en-aut-name=Kunishige Takahiro en-aut-sei=Kunishige en-aut-mei= Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=Sawada Daisuke en-aut-sei=Sawada en-aut-mei= Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=Ketoxime kn-keyword=Ketoxime en-keyword=Enamide synthesis kn-keyword=Enamide synthesis en-keyword=Iron catalyst kn-keyword=Iron catalyst en-keyword=One-electron reduction kn-keyword=One-electron reduction END start-ver=1.4 cd-journal=joma no-vol=98 cd-vols= no-issue= article-no= start-page=38 end-page=46 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Hyperoxia reduces salivary secretion by inducing oxidative stress in mice en-subtitle= kn-subtitle= en-abstract= kn-abstract=OBJECTIVE:
The aim of this study was to determine the effects of prolonged hyperoxia on salivary glands and salivary secretion in mice.
DESIGN:
Male C57BL/6?J mice were kept in a 75% oxygen chamber (hyperoxia group) or a 21% oxygen chamber for 5 days. We measured the secretion volume, protein concentration, and amylase activity of saliva after the injection of pilocarpine. In addition, we evaluated the histological changes induced in the submandibular glands using hematoxylin and eosin and Alcian blue staining and assessed apoptotic changes using the TdT-mediated dUTP nick end labeling (TUNEL) assay. We also compared the submandibular gland expression levels of heme oxygenase-1 (HO-1), superoxide dismutase (SOD)-1, and SOD-2 using the real-time polymerase chain reaction.
RESULTS:
In the hyperoxia group, salivary secretion was significantly inhibited at 5 and 10?min after the injection of pilocarpine, and the total salivary secretion volume was significantly decreased. The salivary protein concentration and amylase activity were also significantly higher in the hyperoxia group. In the histological examinations, enlargement of the mucous acini and the accumulation of mucins were observed in the submandibular region in the hyperoxia group, and the number of TUNEL-positive cells was also significantly increased in the hyperoxia group. Moreover, the expression levels of HO-1, SOD-1, and SOD-2 were significantly higher in the hyperoxia group.
CONCLUSION:
Our results suggest that hyperoxia reduces salivary secretion, and oxidative stress reactions might be involved in this. en-copyright= kn-copyright= en-aut-name=TajiriAyako en-aut-sei=Tajiri en-aut-mei=Ayako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HiguchiHitoshi en-aut-sei=Higuchi en-aut-mei=Hitoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MiyawakiTakuya en-aut-sei=Miyawaki en-aut-mei=Takuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Department of Dental Anesthesiology and Special Care Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Dental Anesthesiology, Okayama University Hospital kn-affil= affil-num=3 en-affil=Department of Dental Anesthesiology and Special Care Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=Hyperoxia kn-keyword=Hyperoxia en-keyword=Hyposalivation kn-keyword=Hyposalivation en-keyword=Oxidative stress kn-keyword=Oxidative stress en-keyword=Saliva kn-keyword=Saliva END start-ver=1.4 cd-journal=joma no-vol=252 cd-vols= no-issue= article-no= start-page=107 end-page=125 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Lithium- and oxygen-isotope compositions of chondrule constituents in the Allende meteorite en-subtitle= kn-subtitle= en-abstract= kn-abstract= We report in situ ion-microprobe analyses of Li- and O-isotope compositions for olivine, low-Ca pyroxene, high-Ca pyroxene, and chondrule mesostasis/plagioclase in nine chondrules from the Allende CV3 chondrite. Based on their mineralogy and O-isotope compositions, we infer that the chondrule mesostasis/plagioclase and ferroan olivine rims were extensively modified or formed during metasomatic alteration and metamorphism on the Allende parent asteroid. We excluded these minerals in order to determine the correlations between Li and both O and the chemical compositions of olivines and low-Ca pyroxenes in the chondrules and their igneous rims. Based on the O-isotope composition of the olivines, nine chondrules were divided into three groups. Average 17O of olivines (Fo>65) in group 1 and 2 chondrules are ?5.3?}?0.4 and ?6.2?}?0.4, respectively. Group 3 chondrules are characterized by the presence of 16O-rich relict grains and the 17O of their olivines range from ?23.7 to ?6.2. In group 1 olivines, as Fa content increases, variation of 7Li becomes smaller and 7Li approaches the whole-rock value (2.4; Seitz et al., 2012), suggesting nearly complete Li-isotope equilibration. In group 2 and 3 olivines, variation of 7Li is limited even with a significant range of Fa content. We conclude that Li-isotope compositions of olivine in group 1 chondrules were modified not by an asteroidal process but by an igneous-rim formation process, thus chondrule olivines retained Li-isotope compositions acquired in the protosolar nebula. In olivines of the group 3 chondrule PO-8, we observed a correlation between O and Li isotopes: In relict 16O-rich olivine grains with 17O of ??25 to ?20, 7Li ranges from ?23 to ?3; in olivine grains with 17O?>??20, 7Li is nearly constant (?8?}?4). Based on the Li-isotope composition of low-Ca pyroxenes, which formed from melt during the crystallization of host chondrules and igneous rims, the existence of a gaseous reservoir with a 7Li????11 is inferred. en-copyright= kn-copyright= en-aut-name=KunihiroTakuya en-aut-sei=Kunihiro en-aut-mei=Takuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OtaTsutomu en-aut-sei=Ota en-aut-mei=Tsutomu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NakamuraEizo en-aut-sei=Nakamura en-aut-mei=Eizo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=The Pheasant Memorial Laboratory, Institute for Planetary Materials, Okayama University kn-affil= affil-num=2 en-affil=The Pheasant Memorial Laboratory, Institute for Planetary Materials, Okayama University kn-affil= affil-num=3 en-affil=The Pheasant Memorial Laboratory, Institute for Planetary Materials, Okayama University kn-affil= en-keyword=Lithium kn-keyword=Lithium en-keyword=Oxygen kn-keyword=Oxygen en-keyword=Chondrule kn-keyword=Chondrule en-keyword=Chondrite kn-keyword=Chondrite en-keyword=Asteroid kn-keyword=Asteroid en-keyword=Allende kn-keyword=Allende en-keyword=Igneous rim kn-keyword=Igneous rim en-keyword=SIMS kn-keyword=SIMS END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue=43 article-no= start-page=151189 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190920 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Fluorescence properties of amido-substituted 2,3-naphthalimides: Excited-state intramolecular proton transfer (ESIPT) fluorescence and responses to Ca2+ ions en-subtitle= kn-subtitle= en-abstract= kn-abstract= 2,3-Naphthalimide derivatives incorporating trifluoroacetamido (3a) and methansulfonamido (3b) functionalities at the 1-position were prepared and their intramolecular excited state proton transfer (ESIPT) fluorescence and responses to metal ions were investigated. Compound 3a displayed normal fluorescence in the amide form in toluene and MeCN and no response to metal cations in the corresponding amidate ion form. In contrast, compound 3b gave off dual emission assignable to normal and ESIPT fluorescence. Additionally, the amidate form of compound 3b displayed off-on fluorescence response to Ca2+. en-copyright= kn-copyright= en-aut-name=WangLei en-aut-sei=Wang en-aut-mei=Lei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=FujiiMayu en-aut-sei=Fujii en-aut-mei=Mayu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NambaMisa en-aut-sei=Namba en-aut-mei=Misa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YamajiMinoru en-aut-sei=Yamaji en-aut-mei=Minoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OkamotoHideki en-aut-sei=Okamoto en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Division of Earth, Life, and Molecular Sciences, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Division of Earth, Life, and Molecular Sciences, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Division of Earth, Life, and Molecular Sciences, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=4 en-affil=Division of Molecular Science, Graduate School of Science and Engineering, Gunma University kn-affil= affil-num=5 en-affil=Division of Earth, Life, and Molecular Sciences, Graduate School of Natural Science and Technology, Okayama University kn-affil= en-keyword=Fluorescence kn-keyword=Fluorescence en-keyword=ESIPT kn-keyword=ESIPT en-keyword=Naphthalimide kn-keyword=Naphthalimide en-keyword=Ca2+ probe kn-keyword=Ca2+ probe END