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ID 16156
Eprint ID
16156
フルテキストURL
Thumnail 98_135.pdf 898 KB
タイトル(別表記)
Metabolic role of the kidney in acute hepatic failure (Guanidino compounds and the metabolic relationship between the liver and kidney)
著者
西谷 恭子 岡山大学医学部麻酔学教室
抄録
A metabolic relationship between the liver and kidney exists in conbination with the urea cycle. We found different concentrations of serum guandino compounds between patients with acute renal failure and those with acute hepatic failure. We made an experimental model of acute hepatic failure in rats by injecting 1,000 mg/kg of D-galctosamine i. p. and evaluated the metabolic changes in the liver and kidney by measuring guandino compound levels using high performance liquid chromatography. We concluded that when the urea cycle was disturbed, the metabolism in the kidney was activated, and the synthesis of GAA (guandino acetic acid) was accelerated for the purpose of excreting ammonium. Also, we thought it possible to evaluate the metabolic compensative ability of the kidney by determining (serum Arginine)/(serum GAA). In the liver and kidney of rats, we found high levels of GBA (guanidino butyric acid), the metabolic pathway of which is unknown. With the progress of liver damage, the release of GBA into the serum was observed.
キーワード
急性肝不全
尿素サイクル
アルギニン
グアニジノ酢酸
グアニジノ酪酸
発行日
1986-02-28
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
98巻
1-2号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
135
終了ページ
143
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/98/1-2/98_1-2_135/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma