ID 32088
JaLCDOI
フルテキストURL
Thumnail fulltext.pdf 1.39 MB
著者
Jin, Gui-Shan Okayama University
Kondo, Eisaku Okayama University
Miyake, Takayoshi Okayama University
Shibata, Masao Medical and Biological Laboratories Co. Ltd.,
Takashima, Takako Medical and Biological Laboratories Co. Ltd.,
Liu, Yi-Xuan Okayama University
Hayashi, Kazuhiko Okayama University
Akagi, Tadaatsu Okayama University
Yoshino, Tadashi Okayama University
抄録

FKHRL1 (FOXO3a), a member of the Forkhead family of genes, has been considered to be involved in the development of breast tumors; however, the in vivo expression and activation status of FKHRL1 in breast tumors still remains unclear. We immunohistochemically demonstrated the expression and intracellular localization of FKHRL1 in human breast tumors by the novel anti-FKHRL1 antibody which is available for formalin-fixed paraffin-embedded specimens. In a total of 51 cases of benign tumors, FKHRL1 was diffusely expressed in all cases, and its intracellular localization was revealed to be cytoplasmic (inactive form) in 94% of cases of intraductal papillomas (16/17) and 91% cases of fibroadenomas (31/34), with a similar pattern to normal glandular epithelium. In invasive ductal carcinomas, 83% of the cases (93/112) diffusely expressed FKHRL1; however, unlike benign tumors, 71% of the cases (66/93) showed the nuclear-targeted, active form of FKHRL1. Moreover, activated FKHRL1 was predominantly observed in scirrhous (29/36, 81% of the cases) and papillotubular (30/38, 79% of the cases) subtypes, compared to the solid-tubular subtype (7/19, 37% of the cases). Furthermore, the cases with nuclear-targeted FKHRL1 showed a tendency to have lymph nodal metastasis with statistical significance (P < 0.0001). Thus, the activation of FKHRL1 seems to be recognized as one of the specific features of invasive ductal carcinoma of the breast.

キーワード
FKHRL1
intracellular localization
breast tumors
Amo Type
Article
発行日
2004-08
出版物タイトル
Acta Medica Okayama
58巻
4号
出版者
Okayama University Medical School
開始ページ
197
終了ページ
205
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT
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