ID 32202
JaLCDOI
フルテキストURL
著者
Ohmori, Toyonori Okayama University
Takamoto, Kazuhiko Okayama University
Ogata, Masana Okayama University
抄録

Some mechanisms to reduce methemoglobin (metHb) formation for the maintenance of normal oxygen transport have been proposed. To study the role of catalase (EC 1.11.1.6), metHb formation in the hemolysate of normal and Japanese acatalasemic human subjects were examined spectrophotometrically. Significantly increased level of metHb was induced by potassium ferrocyanide in the hemolysate of acatalasemic subject. The addition of catalase reduced the metHb formation, while 3-amino-1,2,4-triazole (AT), a specific inhibitor of catalase-H2O2 compound I, increased it. These results obtained from human subjects were well consistent with those from mice and suggested that catalase plays a role in protecting erythrocytes against metHb formation.

キーワード
methemoglobin
catalase
acatalasemia
potassium ferrocyanide
biological monitoring
Amo Type
Article
発行日
1991-10
出版物タイトル
Acta Medica Okayama
45巻
5号
出版者
Okayama University Medical School
開始ページ
321
終了ページ
324
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT
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