Acta Medica Okayama 71巻 4号
2017-08 発行

Mesenchymal Stem Cell Therapy for Ischemic Stroke

Toyoshima, Atsuhiko Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Yasuhara, Takao Department of Spinal Surgery, Shinkomonji Hospital
Date, Isao Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Publication Date
2017-08
Abstract
 To date, many animal studies have indicated the neuroprotective effects of mesenchymal stem cell (MSC) transplantation in ischemic stroke. Several clinical studies have also revealed the safety, feasibility, and neuroprotective effects in ischemic stroke patients. In this review, we present the main approaches of MSC transplantation in ischemic stroke, the mechanisms of MSC therapy, and the current clinical studies on MSC transplantation in ischemic stroke patients. We also explore the safety of MSC transplantation and conclude that MSC therapy will play an important role in the future treatment of ischemic stroke. The optimal timing, approach, and cell dose in the transplantation are important issues for successful clinical application.
Document Type
Review
Keywords
mesenchymal stem cell
ischemic stroke
cell transplantation
clinical trial
Link to PubMed
Thumnail 71_4_263.pdf 1.94 MB