Acta Medica Okayama 71巻 4号
2017-08 発行

Further Molecular Analysis of G6PD Deficiency Variants in Southern Vietnam and a Novel Variant Designated as G6PD Ho Chi Minh (173 A>G; 58 Asp>Gly): Frequency Distributions of Variants Compared with Those in Other Southeast Asian Countries

Kawamoto, Fumihiko Institute of Tropical Disease, Airlangga University Campus C
Matsuoka, Hiroyuki Division of Medical Zoology, Jichi Medical University
Phamd, Nghiem Minh Tu Du Hospital
Hayashi, Taeko Division of Medical Zoology, Jichi Medical University
Kasahara, Yuichi Division of Medical Zoology, Jichi Medical University
Dung, Nguyen The Vietnam National University School of Medicine
Kido, Yasutoshi Department of Environmental & Preventive Medicine, Oita University Faculty of Medicine
Kanbe, Toshio Division of Omics Analysis, Nagoya University Graduate School of Medicine
Tantulara, Indah S. Department of Parasitology, Airlangga University Faculty of Medicine
Publication Date
2017-08
Abstract
We conducted a survey of glucose-6-phosphate dehydrogenase (G6PD) deficiency among newborn babies at Tu Du Hospital, Ho Chi Minh, southern Vietnam. A total of 90 deficient babies were detected, including 85 in the Kinh ethnic group, 4 Chinese, and 1 in the K’Ho minority group. In the Kinh ethnic group, G6PD variants such as G6PD Viangchan (n=32), Kaiping (n=11), Canton (n=8), Chinese-5 (n=7), Union (n=5) and Quing Yuan (n=4) were detected. A variant with silent mutations at 1311 C>T and IVS11 nt 93 T>C was also detected in 17 cases. A novel mutation (173 A>G) in exon 4 with a predicted amino acid change of 58 Asp>Gly was also found in a Kinh newborn girl and her father, and it was designated as G6PD Ho Chi Minh. These findings demonstrated that the Kinh ethnic group in southern Vietnam has 8 different G6PD variants, indicating that the members of this group have many ancestors in terms of G6PD variants from Southeast Asia, China, and Oceania. We compared the frequency distribution of G6PD variants in the Kinh population with those of other Southeast Asian populations, and the Kinh population’s distribution was quite similar to that in the Thai population, but differed from it by the absence of G6PD Mahidol.
Document Type
Original Article
Keywords
G6PD deficiency
G6PD variant
southern Vietnam
Kinh population
Southeast Asia
Link to PubMed