Acta Medica Okayama 71巻 4号
2017-08 発行

A Case of Dermatomyositis with Severe Myalgia and Muscle Weakness Testing Positive for Anti-melanoma Differentiation-associated Gene 5 Antibody

Yamazaki, Kenji Department of Epidemiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Wakabayashi, Hiroshi Department of Rheumatology, Okayama City Hospital
Suganami, Yu Department of General Internal medicine, Okayama City Hospital
Sano, Shinichi Department of General Internal medicine, Okayama City Hospital
Wakunami, Yu Department of General Internal medicine, Okayama City Hospital
Katayama, Takashi Department of General Internal medicine, Okayama City Hospital
Deguchi, Kentaro Department of Neurology, Okayama City Hospital
Nagotani, Shoko Department of Neurology, Okayama City Hospital
Kishida, Masayuki
Publication Date
2017-08
Abstract
We report a case of a woman with typical dermatomyositis (DM) with skin manifestations, severe myalgia and muscle weakness complicated by interstitial lung disease (ILD) and pneumomediastinum. Pneumomediastinum persisted despite treatment with immunosuppressive therapy (steroids and cyclosporine). After the test for anti-melanoma differentiation-associated gene 5 (MDA5) antibody came out positive, we doubled the cyclosporine dose and her condition improved. Despite typical clinical features of DM, in cases complicated by pneumomediastinum or steroid resistance, measurement of anti-MDA5 antibody may be useful for immunosuppressant dose titration.
Document Type
Case Report
Keywords
dermatomyositis
anti-melanoma differentiation-associated gene 5 antibody
interstitial lung disease
pneumomediastinum
Link to PubMed
Thumnail 71_4_341.pdf 3.74 MB