Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

好塩基球の反応性に関する研究 第1編 抗原,抗ヒトIgE刺激時の好塩基球の経時的形態的変化とヒスタミン遊離

中川 三郎 岡山大学医学部第二内科学教室
抄録
Morphological changes in human basophils from atopic asthmatics were observed in whole blood smears with respect to histamine release after stimulation with antigen or anti-IgE. Histamine was rapidly released and was accompanied by morphological changes in basophils upon stimulation with antigen and anti-IgE. A decreased number of basophils and morphological changes including increased cell diameters, increased ratios of the short to long axis diameters, and decreased intracellular granule counts were observed upon the release of histamine after antigen and anti-IgE stimulation. Antigen stimulus induced both more rapid histamine release and morphological changes than anti-IgE stimulation.
キーワード
気管支喘息
好塩基球
形態的変化
特異抗原
抗ヒトIgE
ISSN
0030-1558
NCID
AN00032489