Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

改良型神経伝達物質放出測定装置によるE1マウス海馬切片よりの神経伝達物質放出と抗てんかん薬ゾニサミドの影響に関する研究

遠藤 敦 岡山大学医学部附属分子細胞医学研究施設神経情報学部門
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抄録
Using an experimental apparatus for estimating neurotransmitter release from brain slices, which involved an improved type of perfusion chamber and more well-controlled tube lines than the previous one were aspartic acid and γ-aminobutyric acid (GABA) release from hippocampal slices from epileptic E1 mice estimated more exactly and stably. Zonisamide had no effect on the aspartic acid release from hippocampal slices of E1 mice by zonisamide. However, zonisamide accelerated dose dependently GABA release from hippocampal slices of non-stimulated E1 mice, though no such acceleration was observed in stimulated E1 mice, i. e., repeatedly convulsed E1 mice.
キーワード
E1マウス
アスパラギン酸
γ-アミノ酪酸
ゾニサミド
けいれん
備考
原著
ISSN
0030-1558
NCID
AN00032489