To elucidate the developmental changes in the visual evoked potentials of fronto-central derivation, 137 normal subjects between 0 month 37 years of age were examined. The latencies of early components (N60, P75) showed a gradual decrease up to 1 year of age. The N130 latency of late components showed a rapid decrease in 8 months, and afterwards, showed a gradual decrease until 10 years of age. The P190 latency showed a rapid decrease in 6 months, and afterwards, showed a gradual decrease until 15 years of age. All four components (N60, P75, N130 and P190) showed a tendency of low amplitudes, up to 8 months of age.
During the sleep stages 1, 2 and REM, N130 and P190 latencies were prolonged, and amplitudes decreased, compared with those in the waking state. During sleep stages 3 and 4, these components disappeared. Late components of visual evoked potentials at fronto-central derivations showed signifi-cant developmental changes, and the results of this study can be considered useful in the objective evaluation of brain development.