Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

びまん性汎細気管支炎の病態に関する研究―エリスロマイシン少量長期投与を中心に―

福田 智子 岡山大学医学部第二内科学教室
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抄録
Low dose and long-term erythromycin (EM) therapy showed obvious improvement of symptoms and prognosis in patients with DPB. However, mechanisms involved in these clinical effects of EM therapy remain controversial. In this study, the clinical effects of EM therapy on respiratory function, bacterial flora in the lower airway and serum levels of soluble IL-2 receptor (sIL-2R) as an indicator of T-cell activation were examined. All parameters of respiratory functions in patients with DPB including % VC, % FEV 1.0, % V50, % V25 and V50/V25 showed marked improvements within 6 months of EM therapy. Continuous administration of EM for 6 to 24 months produced minimal changes in these respiratory functions though decreases in some parameters were observed in patients with advanced clinical stage and in eldely patients. The increase of % FEV 1.0 exceeded those of % V50 and % V25 after EM therapy. This indicates severe pathological changes in small airways or variable effects of EM therapy. Bacterial species and sensitivities to antibiotics showed no apparent changes after long-term EM therapy. The serum levels of sIL-2R in patients with DPB were higher than those in normal controls. With EM therapy, serum levels of sIL-2R decreased rapidly within 6 months, but these levels remained higher than those in normal controls, even after long-term EM therapy.
キーワード
diffuse panbronchiolitis
erythromycin
呼吸機能
soluble IL-2 reseptor
喀痰中細菌叢
備考
原著
ISSN
0030-1558
NCID
AN00032489