Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

マウス口腔粘膜および頭部皮膚に対する血管収縮剤エピネフリンの放射線防護効果の検討

高 献書 岡山大学医学部放射線医学教室
中川 富夫 岡山大学医学部放射線医学教室
山本 道法 岡山大学医学部放射線医学教室
黒田 昌宏 岡山大学医学部放射線医学教室 Kaken ID researchmap
栄 勝美 岡山大学医学部放射線医学教室
清水 光春 岡山大学医学部放射線医学教室
新屋 晴孝 岡山大学医学部放射線医学教室
竹田 芳弘 岡山大学医学部放射線医学教室 Kaken ID
上者 郁夫 岡山大学医学部放射線医学教室
平木 祥夫 岡山大学医学部放射線医学教室
川崎 祥二 岡山大学医療技術短期大学部診療放射線技術学科
Thumnail 108_139.pdf 1.52 MB
抄録
Epinephrine is the most widely used vasoconstrictive drug. However, its radioprotective potential has not yet been studied for radiation-induced mucositis and dermatitis. Other vasoconstrictive drugs induce a radioprotective effect, but are not used because of their severe side effects. We studied the radioprotective effect of epinephrine on the oral mucosa and scalp of the mice. The radiation dose was 20Gy in a single fraction to the head of the mouse. In the group treated with epinephrine ointment, secretion from the oral cavity was slight, body wieght loss was less and hair loss was observed in fewer cases compared to those in the group without of epinephrine ointment. The mechanism is thought to be related to oxygenation. Epinephrine causes vasoconstriction, therefore the blood supply is lowered and the oxygen concentration in the tissue decline. In conclusion, epinephrine is considered to have potential as a radioprotective ointment for mucous membranes and skin.
キーワード
エピネフリン
放射線防護剤
血管収縮
酸素効果
マウス粘膜皮膚
備考
原著
ISSN
0030-1558
NCID
AN00032489