Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

高血圧自然発症ラットにおける脈絡膜血管病変の組織学的研究 第2報 晩期高血圧自然発症ラットにおける脈絡膜と網膜色素上皮細胞の変化について

坂口 紀子 岡山大学医学部眼科学教室
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抄録
The pathological changes in the choroid and the retinal pigment epithelium in spontaneously hypertensive rats (SHR) aged 42-117 weeks were observed by transmission electron microscopy. Wistar Kyoto rats (WKY) were also studied as normotensive controls. Some of the endothelial cells of the choroidal arterioles and capillaries were degenerated. Focal cytoplasmic necrosis of the arteriolar smooth muscle cells was seen. The choroid showed severe sclerotic changes, and the retinal pigment epithelium was degeneated with dilated basal infoldings and intracellular vacuoles. Long-term hypertension causes degeneration of the outer retinal layer due to the obstructive changes in the choroidal vasculature.
キーワード
高血圧
脈絡膜
網膜
病理
備考
原著
ISSN
00301558
NCID
AN00032489