Journal of Okayama Medical Association
Published by Okayama Medical Association

<Availability>
Full-text articles are available 3 years after publication.

ニガウリ抽出物の血糖降下作用に関する文献的考察

万倉 三正 岡山大学大学院医歯薬学総合研究科 医療薬学・先端薬物療法開発学
野田 泰子 岡山大学医学部 病原細菌学
森 昭胤 岡山大学
Thumnail 124_15.pdf 4.62 MB
抄録
Diabetes mellitus (DM) represents a global health and economical problem. Many patients with DM in Asia, South America, India and East Africa have traditionally used the water extract of unripe fruits of Momordica charantia (bitter melon) as some form of complementary and alternative medicine. Studies of laboratory animals have shown the beneficial blood-glucose lowering and anti-diabetic effects of this remedy. Some oral components that bring lower blood glucose level have been isolated : charantin (sterol glycosides), charantin (polypeptide) and cucurbine-type triterpenes. Part of their actions are related to AMP-activated kinase and repression of the oxidative stress that is increased in DM. Most clinical reports are not fully convincing due to the lack of randomized control studies. The present article reviews the pharmacological and clinical effects of bitter melon with special emphasis on the anti-diabetic effects, and some effects that would require caution in the context of human trials.
キーワード
ニガウリ (bitter melon)
Momordica charantia
糖尿病 (diabetes mellitus)
酸化ストレス (oxidative stress)
備考
総説(Review)
ISSN
0030-1558
NCID
AN00032489
DOI