An antigen-antibooy reaction was repeated for 6 months long by intravenous injection of 4 times diluted cow serum with phosphatide and by injection of α-streptococci in paranasal
cavity of rabbits. They were let free from any procedure for more than 1 month to 8 months. Thus the chronic cerebral local anaphylactic rabbits were made. The Ch-E activity in each motor cortex, Ammon's horn and nucleus lenticularis was measured. The results were as follows: 1) Ch-E acitivty in each rabbit's brain was ranged in the order of the motor cortex (highest), Ammon's horn and then nucleus lenticularis. 2) In the chronic cerebral anaphylactic rabitbs, Ch-E activity in the motor cortex and Ammon's horn was much higher than that of normal one, and in the nucleus lenticularis it tended to increase slightly. 3) The increase of Ch-E activity in each part showed no fluctuation even during long time without any management. 4) The increase of Ch-E activity in each part was not influenced by the kinds of sensitizing antigen or of the methods of sensitization. 5) The permanent increase of Ch-E activity and abnormal accelaeration of brain metabolism in rabbits brains were observed by the repeated reactions as above-stated for a long time It would appear that, the chronic cerebral local anaphylactic rabbits were given an experimental epileptic arrangement.