1. After adrenalectomy bleeding and erosion on the glandular portion of the rats stomach were observed. The pathogenesis of this ulceration was suggested to be induced by serous disturbance of the local blood circulaton. 2. When 0.9% NaCl solution and cortisone were administered for adrenalectomized rats to recover them from the adrenal insufflciency, circulatory disturbance was minimized, probably due to the restoration of humoral change. 3. In vagotomized rats ulcer formation or disturbance of circulation were minimized even after adrenalecomy, therefore it was suggested that the vagotomy did be one of the causes of circulatory disturbance. 4. The combined procedure of hypophysectomy and adrenalectomy produced high degree of ulceration, and in this case the nature of histological change was similar to that after adrenalectomy alone. With these findings it was concluded that the more intensively the condition of the hormonal disharmony became, the more prominently appeared the disturbance of the local blood circulation.